Skip to main content
SpringerLink
Log in

Electrochemical Investigation of Kinetic and Allied Aspects of Biological Redox Reactions

  • Chapter
Biological Aspects of Electrochemistry

Part of the book series: Experientia Supplementum ((EXS,volume 18))

Summary

The relations are summarized between potential, current and derived data, as obtained by polarographically derived technics, and (a) reversibility of electron-transfer processes and the various factors producing irreversibility in such processes, and (b) the study of homogeneous solution kinetics, the kinetics of reactions occurring near the electrode whose equilibria are perturbed by electrolytic processes, and heterogeneous electron-transfer kinetics.

The application of electrochemical methods and theories to the investigation and resolution of problems in the kinetics of biochemical reactions is illustrated by case histories involving biologically important chemical species and phenomena: (a) measurement by cyclic voltammetry of the dimerization and protonation rates of the free radical anion produced on reduction of pyrimidine; (b) determination of association, conformation and orientation in nucleosides and nucleotides by D.M.E. polarography; (c) relation of electrode kinetics to structure and to rates of homogeneous redox reactions as seen in the correlations of standard heterogeneous rate constants with the nature of the ligands complexing the Fe(III)-Fe(II) couple and with substitution on the quinone moiety; (d) kinetic and adsorption data on purine as obtained by alternating current polarography (total, phase-selective and second-harmonic).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. C.N. Reilley and R.W. Murray, in I.M. Kolthoff and P.J. Elving, Eds., Treatise on Analytical Chemistry, Interscience, New York, 1963, Part I, Vol. 4, pp. 2163–2232.

    Google Scholar 

  2. L. Meites, Polarographic Techniques, 2nd ed., Interscience, New York, 1965

    Google Scholar 

  3. C.L. Perrin, in S.G. et al., Eds., Progress in Physical Organic Chemistry, Interscience, New York, 1963, Vol. III, pp. 165–316.

    Google Scholar 

  4. P.J. Elving, Pure Appl. Chem. 7, 423 (1963).

    Article  Google Scholar 

  5. R.A. Marcus, Discussions Faraday Soc, No. 29, 21 (1960).

    Article  Google Scholar 

  6. R.A. Marcus, J. Chem. Phys. 43, 679 (1965).

    Article  Google Scholar 

  7. W.F. Libby, J. Phys. Chem. 56, 863 (1952).

    Article  Google Scholar 

  8. J.E.B. Randles, Trans. Faraday Soc. 48, 828 (1952).

    Article  Google Scholar 

  9. P. Delahay, New Instrumentl Methods in Electrochemistry, Interscience, New York, 1954.

    Google Scholar 

  10. I.M. Kolthoff and J.J. Lingane, Polarography, 2nd ed., Interscience, New York, 1952.

    Google Scholar 

  11. L. Meites, in I.M. Kolthoff and P.J. Elving, Eds., Treatise on Analytical Chemistry, Interscience, New York 1963, Part. I, Vol. 4, pp. 2303–79.

    Google Scholar 

  12. O.H. Muller, in A. Weisserger, Ed., Physical Methods of Organic Chemistry, 3rd ed., Interscience, New York, 1960, Part. IV, pp. 3155–379.

    Google Scholar 

  13. C.L. Rulfs and P.J. Elving, in C.A. Hampel, Ed., Encyclopedia of Electrochemistry Reinhold, New York, 1964, pp. 944.

    Google Scholar 

  14. I.M. Kolthoff and P.J. Elving, Eds., Treatise on Analytical Chemistry, Interscience, New York, 1963, Part. I, Vol. 4 (Electrical Methods of Analysis).

    Google Scholar 

  15. R.S. Nicholson and I. Shain, Anal. Chem. 36, 706 (1964).

    Article  Google Scholar 

  16. R.S. Nicholson and I. Shain, Anal. Chem. 36, 1212 (1964).

    Article  Google Scholar 

  17. R.S. Nicholson and I. Shain, Anal. Chem. 37, 178 (1965).

    Article  Google Scholar 

  18. R.S. Nicholson and I. Shain, Anal. Chem. 37, 190 (1965).

    Article  Google Scholar 

  19. R.S. Nicholson, Anal. Chem. 37, 1351 (1965).

    Article  Google Scholar 

  20. G.L. Booman and D.T. Pence, Anal. Chem. 37, 1366 (1965).

    Article  Google Scholar 

  21. M.L. Olmstead and R.S. Nicholson, Anal. Chem. 38, 150 (1966).

    Article  Google Scholar 

  22. D.S. Polcyn and I. Shain, Anal. Chem. 38, 370 (1966).

    Article  Google Scholar 

  23. R.S. Nicholson, J.M. Wilson and M.L. Olmstead, Anal. Chem. 38, 542 (1966)

    Article  Google Scholar 

  24. R.S. Nicholson, Anal. Chem. 38, 1406 (1966).

    Article  Google Scholar 

  25. R.H. Wopschall and I. Shain, Anal. Chem. 39, 1527 (1967).

    Article  Google Scholar 

  26. J.M. Saveant and E. Vianello, Electrochim. Acta 12, 1545 (1967).

    Article  Google Scholar 

  27. M. Mastragostino, L. Nadio and J.M. Saveant, Electrochim. Acta 13, 721 (1968).

    Article  Google Scholar 

  28. M.L. Olmstead, R.G. Hamilton and R.S. Nicholson, Anal. Chem. 41, 260 (1969).

    Article  Google Scholar 

  29. G.L. Booman and D.T. Pence, Anal. Chem. 41, 746 (1969).

    Article  Google Scholar 

  30. M.L. Olmstead and R.S. Nicholson, Anal. Chem. 41, 862 (1969).

    Article  Google Scholar 

  31. R.L. Myers and I. Shain, Anal. Chem. 41, 980 (1969).

    Article  Google Scholar 

  32. B. Kastening, Anal. Chem. 41, 1142 (1969).

    Article  Google Scholar 

  33. M.H. Hulbert and I. Shain, Anal. Chem. 42, 162 (1970).

    Article  Google Scholar 

  34. M.S. Shuman, Anal. Chem. 42, 521 (1970).

    Article  Google Scholar 

  35. D.E. Smith, in A.J. Bard, Ed., Electroanalytical Chemistry, Marcel Dekker, New York, 1966, Vol. 2, pp. 21–155.

    Google Scholar 

  36. T.G. McCord and D.E. Smith, Anal. Chem. 40, 1967 (1968).

    Article  Google Scholar 

  37. T.G. McCord and D.E. Smith, Anal. Chem. 41, 131 (1969).

    Article  Google Scholar 

  38. T.G. McCord and D.E. Smith, Anal. Chem. 41, 1423 (1969).

    Article  Google Scholar 

  39. T.G. McCord and D.E. Smith, J. Electroanal. Chem. 26, 61 (1970).

    Article  Google Scholar 

  40. T.G. McCord and D.E. Smith, Anal. Chem. 42, 2 (1970).

    Article  Google Scholar 

  41. B. Breyer and H.H. Bauer, Alternating Current Polarography and Tensammetry, Interscience Publishers, New York, 1963.

    Google Scholar 

  42. B. Breyer, Pure Appl. Chem. 15, 313 (1967).

    Article  Google Scholar 

  43. M. Sluyters-Rehbach and J.H. Sluyters, in A.J. Bard, Ed., Electroanalytical Chemistry, Marcel Dekker, New York, 1970, Vol. 4, pp. 1–128.

    Google Scholar 

  44. B. Timmer, M. Sluyters-Rehbach and J.H. Sluyters, J. Electroanal. Chem. 14, 169 (1967).

    Article  Google Scholar 

  45. B. Timmer, M. Sluyters-Rehbach and J.H. Sluyters, J. Electroanal. Chem. 14, 181 (1967).

    Article  Google Scholar 

  46. D.E. Smith and T.G. McCord, Anal. Chem. 40, 474 (1968).

    Article  Google Scholar 

  47. R. DeLevie and A.A. Husovsky, J. Electroanal. Chem. 20, 181 (1969).

    Article  Google Scholar 

  48. E.R. Brown, D.E. Smith and G.L. Booman, Anal. Chem. 40, 1411 (1968).

    Article  Google Scholar 

  49. R.E. Evilia and A.J. Diefenderfer, Anal. Chem. 39, 1885 (1967).

    Article  Google Scholar 

  50. L. Meites, in A. Weissberger, Ed., Physical Methods of Organic Chemistry, 3rd ed., Interscience, New York, 1960, pp. 3281–333.

    Google Scholar 

  51. L. Meites, Rec. Chem. Progr. 22, 81 (1961).

    Google Scholar 

  52. P. Zuman, J. Polarog. Soc. 13, 53 (1967).

    Google Scholar 

  53. A.J. Bard and K.S.V. Santhanam, in A.J. Bard, Ed., Electroanalytical Chemistry, Marcel Dekker, New York, 1970, Vol. 4, pp. 215–315.

    Google Scholar 

  54. W.A. Struck and P.J. Elving, Biochemistry, 4, 1343 (1965).

    Article  Google Scholar 

  55. G. Dryhurst and P.J. Elving, J. Electrochem. Soc. 115, 1014 (1968).

    Article  Google Scholar 

  56. G. Semerano, Ric. Sci. 22, Suppl. 197 (1952).

    Google Scholar 

  57. P. Zuman, in V. Gold, Ed., Advances in Physical Organic Chemistry, Academic, Press, New York, 1967, Vol. 5, pp. 1–52.

    Google Scholar 

  58. H. Strehlow, in S.L. Friess et al., Eds., Investigations of rates and Mechanism of Reactions, Interscience, New York, 1963, Part II, pp. 799–843.

    Google Scholar 

  59. W.J. Seagers and P.J. Elving, J. Amer. Chem. Soc. 73, 947 (1951).

    Article  Google Scholar 

  60. D. Kalab, Experientia 22, 23 (1966).

    Article  Google Scholar 

  61. R. Pleticha-Lansky and J.J. Weiss, Anal. Biochem. 16, 510 (1966).

    Article  Google Scholar 

  62. V. Vetterl, Collect. Czech. Chem. Commun 34, 673 (1969).

    Article  Google Scholar 

  63. B. Janik and P.J. Elving, J. Amer. Chem. Soc. 92, 235 (1970).

    Article  Google Scholar 

  64. R. Brdicka, V. Hanus and J. Koutecky, in P. Zuman, Ed., Progress in Polarography, Interscience, New York, 1962, pp. 145–99.

    Google Scholar 

  65. A. Bewick, M. Fleischmann and J.N. Hiddleston, in G.J. Hills, Ed. Polarography 1964, Interscience, New York, 1966, pp. 57–78.

    Google Scholar 

  66. J.W. Ashley and C.N. Reilley, J. Electroanal. Chem. 7, 253 (1964).

    Google Scholar 

  67. D.M. Oglesby, J.D. Johnson and C.N. Reilley, Anal. Chem. 38, 385 (1966).

    Article  Google Scholar 

  68. K.J. Vetter, Elektrochemische Kinetik, Springer-Verlag, Berlin, 1961.

    Google Scholar 

  69. K.J. Vetter, Electrochemical Kinetics: Theoretical and Practical Aspects, Academic, Press, New York, 1967.

    Google Scholar 

  70. K.J. Vetter, Electrochemical Kinetics: Theoretical and Practical Aspects, Academic, Press, New York, 1967.

    Google Scholar 

  71. B.B. Damaskin, Principles of Current Methods for the Study of Electrochemical Reactions, McGraw-Hill, New York, 1967.

    Google Scholar 

  72. B.E. Conway, Theory and Principles of Electrode Processes, Ronald, New York, 1965.

    Google Scholar 

  73. P. Delahay, Double Layer and Electrode Kinetics, Interscience, New York, 1965.

    Google Scholar 

  74. W.L. Reynolds and R.W. Lumry, Mechanisms of Electron Transfer, Ronald, New York, 1966.

    Google Scholar 

  75. A.J. Bard, Ed., Electroanalytical Chemistry, Marcel Dekker, New York, 1966, Vols. 1 et seq.

    Google Scholar 

  76. J. O’M. Bockris and B.E. Conway, Eds., Modern Aspects of Electrochemistry, Butterworths, London, 1954, Vols. 1 et seq.

    Google Scholar 

  77. P. Delahay and C.W. Tobias, Eds., Advances in Chemistry and Electrochemical Engineering, Interscience, New York, 1961, Vols. 1 et seq.

    Google Scholar 

  78. W.H. Reinmuth, Anal. Chem. 40, 185R (1968).

    Article  Google Scholar 

  79. P. Delahay, in P. Delahay and C. Tobias, Eds., Advances in Electrochemistry and Electrochemical Engineering, Interscience, New York, 1961, Vol. I, pp. 233–318.

    Google Scholar 

  80. G.C. Barker, in G.J. Hills, Ed., Polarography 1964, Interscience, New York, 1966, pp. 25–47.

    Google Scholar 

  81. S.G. Mairanovskii, Electrochim. Acta 9, 803 (1964).

    Article  Google Scholar 

  82. H.H. Bauer, J. Electroanal. Chem. 16, 419 (1968).

    Article  Google Scholar 

  83. H.W. NĂĽrnberg, Studien mit Modernen Polarographischen Techniken zur Kinetik Schneller Chemischer und Elektrochemischer Schritte von Protonentransferprozessen an der Quecksilberelektrode, Berichte der Kernsforschungsanlage JĂĽlich No. 475, 1967; Fortschr. Chem Forsch. 8, 241 (1967).

    Article  Google Scholar 

  84. A.W. Fonds, Chem. Weekblad. 61, 548 (1965).

    Google Scholar 

  85. J.E. O’Reilly and P.J. Elving, J. Amer. Chem. Soc. 93, 1871 (1971).

    Article  Google Scholar 

  86. D.L. Smith and P.J. Elving, J. Amer. Chem. Soc. 84, 2741 (1962).

    Article  Google Scholar 

  87. J.E. O’Reilly and P.J. Elving, J. Electroanal. Chem. 21, 169 (1969).

    Article  Google Scholar 

  88. G. Dryhurst and P.J. Elving, Talanta, 16, 855 (1969).

    Article  Google Scholar 

  89. P. Zuman, Substituent Effects in Organic Polarography, Plenum Press, New York, 1967.

    Google Scholar 

  90. B. Janik and P.J. Elving, J. Electrochem. Soc. 116, 1087 (1969).

    Article  Google Scholar 

  91. R.A. Marcus, Discussions Faraday Soc, No. 45, 7 (1968).

    Article  Google Scholar 

  92. W.M. Clark, Oxidation-Reduction Potentials of Organic Systems, Williams and Wilkins, Baltimore, 1960.

    Google Scholar 

  93. A.A. Vlcek, in F.A. Cotton, Ed., Progress in Inorganic Chemistry, Interscience, New York, 1962, Vol. 5, pp. 211–384.

    Google Scholar 

  94. S.J. Pace, Ph.D. Thesis, Syracuse University, June 1970.

    Google Scholar 

  95. F.V. Lovecchio, S.J. Pace and D.J. Macero, Inorg. Chim. Acta 3, 94 (1969).

    Article  Google Scholar 

  96. J.L. Huntington and D.G. Davis, J. Electrochem. Soc. 118, 57 (1971).

    Article  Google Scholar 

  97. J.L. Huntington and D.G. Davis, J. Mag. Reson. 3, 456 (1970).

    Google Scholar 

  98. M.E. Peover and J.S. Powell, J. Electroanal. Chem. 20, 427 (1969).

    Article  Google Scholar 

  99. R.A. Marcus, J. Phys. Chem. 67, 853 (1963).

    Article  Google Scholar 

  100. O. Ryba, J. Pilar and J. Petranek, Collect. Czech. Chem. Commun. 33, 26 (1968).

    Article  Google Scholar 

  101. O. Ryba, J. Petranek and J. Pospisil, Collect. Czech. Chem. Commun. 30, 843 (1965).

    Article  Google Scholar 

  102. M.E. Peover, Nature 1962, 193.

    Google Scholar 

  103. M.E. Peover, Nature 1962, 475.

    Google Scholar 

  104. F.A. Matsen, J. Chem. Phys. 24, 602 (1956).

    Article  Google Scholar 

  105. R.M. Hedges and F.A. Matsen, J. Chem. Phys. 28, 950 (1958).

    Article  Google Scholar 

  106. J.F. Coetzee and G.R. Padmanabhan, J. Phys. Chem. 66, 1708 (1962).

    Article  Google Scholar 

  107. M.G. Evans and J. de Heer, Quart. Rev. 4, 94 (1950).

    Article  Google Scholar 

  108. B.R. Eggins and J.Q. Chambers, J. Electrochem. Soc. 117, 186 (1970).

    Article  Google Scholar 

  109. M.E. Peover, J. Chem. Soc. 1962, 4540.

    Google Scholar 

  110. M.E. Peover, in A.J. Bard, Ed., Electroanalytical Chemistry, Marcel Dekker, New York, 1967, Vol. 2, pp. 1–51.

    Google Scholar 

  111. W.M. Latimer, Oxidation Potentials, 2nd ed., Prentice-Hall, New York, 1952, pp. 138–9.

    Google Scholar 

  112. G.M. Richardson and R.R. Cannan, Biochem. J. 23, 68 (1929).

    Google Scholar 

  113. E.S. Hill and L. Michaelis, Science 78, 485 (1933).

    Article  Google Scholar 

  114. G. Sartori and A. Liberti, Ric. Sci. 16, 313 (1946).

    Google Scholar 

  115. S. Ono, M. Takazi and T. Wasa, Bull. Chem. Soc. Japan 31, 364 (1958).

    Article  Google Scholar 

  116. W.A. Hoffman, J. Sci. Labs. Denison Univ. 45, 215 (1962).

    Google Scholar 

  117. W.A. Struck and P.J. Elving, J. Amer. Chem. Soc. 86, 1229 (1964).

    Article  Google Scholar 

  118. D.L. Smith and P.J. Elving, J. Amer. Chem. Soc. 84, 1412 (1962).

    Article  Google Scholar 

  119. S.G. Mairanovskii, J. Electroanal. Chem. 4, 166 (1962).

    Google Scholar 

  120. G.H. Aylward and J.W. Hayes, Anal. Chem. 37, 195 (1965).

    Article  Google Scholar 

  121. G.H. Aylward and J.W. Hayes, Anal. Chem. 37, 197 (1965).

    Article  Google Scholar 

  122. T.G. McCord, H.L. Hung and D.E. Smith, J. Electroanal. Chem. 21, 5 (1969).

    Article  Google Scholar 

  123. J.E.B. Randles and K.W. Somerton, Trans. Faraday Soc. 48, 937 (1952).

    Article  Google Scholar 

  124. M.D. Wijnen and W.M. Smit, Rec. Trav. Chim. 79, 289 (1960).

    Article  Google Scholar 

  125. F.C. Anson, Anal. Chem. 33, 939 (1961).

    Article  Google Scholar 

  126. R. Parsons, Handbook of Electrochemical Constants, Butterworths, London, 1959.

    Google Scholar 

  127. A. Regner and J. Balej, Collect. Czech. Chem. Commun. 26, 237 (1961).

    Google Scholar 

  128. F. Pantani and G. Ciantelli, J. Electroanal. Chem. 14, 423 (1967).

    Article  Google Scholar 

  129. A.A. Vlcek, Collect. Czech. Chem. Commun. 20, 894 (1955).

    Google Scholar 

  130. J.G. Montalvo, Jr. and D.G. Davis, J. Electroanal. Chem. 23, 166 (1969).

    Article  Google Scholar 

  131. T.M. Bednarski and J. Jordan, J. Amer. Chem. Soc. 86, 5690 (1964).

    Article  Google Scholar 

  132. T.M. Bednarski and J. Jordan, J. Amer. Chem. Soc. 89, 1552 (1967).

    Article  Google Scholar 

  133. D.G. Davis and R.F. Martin, J. Amer. Chem. Soc. 88, 1365 (1966).

    Article  Google Scholar 

  134. J.E. Page and G. Wilkinson, J. Amer. Chem. Soc. 74, 6149 (1952).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The University of Michigan, Ann Arbor, Michigan, 48104, USA

    P. J. Elving & S. J. Pace

Authors
  1. P. J. Elving
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. J. Pace
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Istituto Superiore di SanitĂ , Rome, Italy

    Giulio Milazzo

  2. Istituto Chimico dell’Università, Rome, Italy

    Peter E. Jones (Visiting Professor) (Visiting Professor)

  3. Istituto di Chimica, Facoltà di Ingegneria dell’Università, Rome, Italy

    Liliana Rampazzo

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer Basel AG

About this chapter

Cite this chapter

Elving, P.J., Pace, S.J. (1971). Electrochemical Investigation of Kinetic and Allied Aspects of Biological Redox Reactions. In: Milazzo, G., Jones, P.E., Rampazzo, L. (eds) Biological Aspects of Electrochemistry. Experientia Supplementum, vol 18. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5848-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-5848-9_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5850-2

  • Online ISBN: 978-3-0348-5848-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation