Abstract
Quantitative multiparameter structure-activity studies have been performed on a series of 2-substituted isonicotinic acid hydrazides (Fig. 1). Isonicotinic acid hydrazide (INH) has been one of the most effective drugs in tuberculosis therapy since 1952 when its antibacterial activity against Mycobacterium tuberculosis was discovered [1, 2]. Numerous derivatives have been prepared since then, however, none of them possessed a higher activity than INH itself.
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References
Greenberg, E. and Schnitzer, R.J., Quart. Bull. Sea View Hosp. 13, 3 (1952).
Offe, H. A., Siefken W. and Domagk, G. Naturwissenschaften 39, 118 (1952).
Krüger-Thiemer, E., Jber. Borstel. 3, 192 (1956). 4, 299 (1957).
Seydel, J.K., Wempe E. and Nestler, H.J., Arzneim.-Forsch. 18, 362 (1968).
Albert, A. and Serjeant, E. P., in: Ionization constants of acids and bases, Wiley, New York, 1962.
Schofield, K., in: Hetero-aromatic nitrogen compounds, Plenum Press, New York, 1967, p. 146.
Charton, M., J. Amer. chem. Soc. 91, 615 (1969).
Deady, L.W. and Zoltewich, J.A., J. org. Chem. 37, 603 (1972).
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Schaper, KJ., Seydel, J.K. (1976). Structure-Activity Correlations in a Homologous Series of 2-Substituted Isonicotinic Acid Hydrazides. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_16
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DOI: https://doi.org/10.1007/978-3-0348-5795-6_16
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5796-3
Online ISBN: 978-3-0348-5795-6
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