Frontiers in Crustacean Neurobiology

Part of the series Advances in Life Sciences pp 417-423

Membrane Currents in Rhythmic Neurons

  • Jorge GolowaschAffiliated withBiology Department, Brandeis University
  • , Wanita KumarAffiliated withBiology Department, Brandeis University
  • , Eve MarderAffiliated withBiology Department, Brandeis University

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The peptide proctolin can initiate strong pyloric and gastric rhythms from the stomatogastric ganglion (STG) of lobsters and crabs. To account for the effects of proctolin on the neural networks that produce the pyloric rhythms, we have attempted to determine the specific neural targets for proctolin, and to describe the membrane currents influenced by it. To this end, we have placed individual STG neurons in dissociated cell culture. We find that many of these neurons oscillate subsequent to hyperpolarizing pulses, and that proctolin increases the oscillatory activity of these neurons.