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Further Characterization of CDC25Mm, a Mammalian Activator of p21ras

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Molecular Oncology and Clinical Applications

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

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Summary

By using a cotransfection assay with a ras-responsive fos-luciferase reporter gene, we present evidence that the catalytic domain of CDC25Mm constitutively activates p21ras in mammalian cells in vivo. Using immunopurified CDC25Mm-specific antibodies we show that different protein species are recognized in mouse tissues.

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Author information

Authors and Affiliations

  1. Dipartimento di Fisiologia e Biochimica Generali, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy

    E. Sturani, R. Zippel, E. Martegani, M. Vanoni, C. Ferrari, P. Coccetti & L. Alberghina

Authors
  1. E. Sturani
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  2. R. Zippel
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  3. E. Martegani
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  4. M. Vanoni
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  5. C. Ferrari
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  6. P. Coccetti
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  7. L. Alberghina
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Editor information

Editors and Affiliations

  1. Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, I-00168, Roma, Italy

    A. Cittadini  & T. Galeotti  & 

  2. Jefferson Cancer Institute, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA, 19107-6790, USA

    R. Baserga

  3. Dept. Oncology, Free University Hospital, De Boelelaan 1117, NL-1007 MB, Amsterdam, The Netherlands

    H. M. Pinedo

  4. Istituto di Ricerche, Farmacologiche “M. Negri”, Consorzio Mario Negri Sud, I-66030, S. Maria Imbaro, Italy

    D. Corda

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© 1993 Springer Basel AG

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Sturani, E. et al. (1993). Further Characterization of CDC25Mm, a Mammalian Activator of p21ras. In: Cittadini, A., Baserga, R., Pinedo, H.M., Galeotti, T., Corda, D. (eds) Molecular Oncology and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5663-8_17

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  • DOI: https://doi.org/10.1007/978-3-0348-5663-8_17

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5665-2

  • Online ISBN: 978-3-0348-5663-8

  • eBook Packages: Springer Book Archive

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