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Regulation of Protein Kinase C

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Molecular Oncology and Clinical Applications

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Summary

Distinct mechanisms operate to regulate the protein kinase C (PKC) gene family through the production of diacylglycerol (DAG). For the phospholipases C that act upon inositol lipids, agonist induced activation via disparate receptor types involves different strategies. This is likely to pertain to other sources of DAG. The production of DAG by these various means activates PKC isotypes in a non-uniform manner. This indicates that the context of DAG production is critical; whether this reflects coincident effectors (e.g. Ca2+, fatty acids) or compartmentalisation, has yet to be resolved.

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Author information

Authors and Affiliations

  1. Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK

    P. J. Parker, A. Carozzi, L. Dekker, R. S. Ginger, N. Goode, S. Kiley & A. R. Olivier

Authors
  1. P. J. Parker
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  2. A. Carozzi
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  3. L. Dekker
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  4. R. S. Ginger
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  5. N. Goode
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  6. S. Kiley
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  7. A. R. Olivier
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Editor information

Editors and Affiliations

  1. Istituto di Patologia Generale, UniversitĂ  Cattolica del Sacro Cuore, Largo Francesco Vito, 1, I-00168, Roma, Italy

    A. Cittadini  & T. Galeotti  & 

  2. Jefferson Cancer Institute, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA, 19107-6790, USA

    R. Baserga

  3. Dept. Oncology, Free University Hospital, De Boelelaan 1117, NL-1007 MB, Amsterdam, The Netherlands

    H. M. Pinedo

  4. Istituto di Ricerche, Farmacologiche “M. Negri”, Consorzio Mario Negri Sud, I-66030, S. Maria Imbaro, Italy

    D. Corda

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© 1993 Springer Basel AG

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Parker, P.J. et al. (1993). Regulation of Protein Kinase C. In: Cittadini, A., Baserga, R., Pinedo, H.M., Galeotti, T., Corda, D. (eds) Molecular Oncology and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5663-8_14

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  • DOI: https://doi.org/10.1007/978-3-0348-5663-8_14

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5665-2

  • Online ISBN: 978-3-0348-5663-8

  • eBook Packages: Springer Book Archive

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