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Regulation of MnSOD Expression by Manganese in Tumors

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Molecular Oncology and Clinical Applications

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

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Summary

The data reported indicate that the expression of Mn-dependent superoxide dismutase is a (pre)-transcriptional event. Evidences obtained from several experimental systems, neoplastic and non neoplastic, suggest that manganese is involved in the control of MnSOD expression. The molecular mechanisms implicated could consist in the activation of a transcription factor sensitive to some reactive oxygen species, such as H2O2, whose production rate is enhanced by this metal.

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Author information

Authors and Affiliations

  1. Institute of General Pathology, Catholic University, Largo F. Vito 1, 00168, Roma, Italy

    S. Borrello, M. E. De Leo & T. Galeotti

Authors
  1. S. Borrello
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  2. M. E. De Leo
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  3. T. Galeotti
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Editor information

Editors and Affiliations

  1. Istituto di Patologia Generale, UniversitĂ  Cattolica del Sacro Cuore, Largo Francesco Vito, 1, I-00168, Roma, Italy

    A. Cittadini  & T. Galeotti  & 

  2. Jefferson Cancer Institute, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA, 19107-6790, USA

    R. Baserga

  3. Dept. Oncology, Free University Hospital, De Boelelaan 1117, NL-1007 MB, Amsterdam, The Netherlands

    H. M. Pinedo

  4. Istituto di Ricerche, Farmacologiche “M. Negri”, Consorzio Mario Negri Sud, I-66030, S. Maria Imbaro, Italy

    D. Corda

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© 1993 Springer Basel AG

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Borrello, S., De Leo, M.E., Galeotti, T. (1993). Regulation of MnSOD Expression by Manganese in Tumors. In: Cittadini, A., Baserga, R., Pinedo, H.M., Galeotti, T., Corda, D. (eds) Molecular Oncology and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5663-8_11

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  • DOI: https://doi.org/10.1007/978-3-0348-5663-8_11

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5665-2

  • Online ISBN: 978-3-0348-5663-8

  • eBook Packages: Springer Book Archive

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