The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

  • David G. Nicholls
  • Vibeke S. M. Bernson
  • Gillian M. Heaton
Part of the Experientia Supplementum book series (EXS, volume 32)


The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.


Brown Adipose Tissue Proton Conductance Outer Face Purine Nucleotide Adenine Nucleotide Translocase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    Cannon, B., Sundin, U. and Romert, L.: FEBS Lett. 74 (1977) 43–46.CrossRefGoogle Scholar
  2. [2]
    Flatmark, T. & Pederson, J.I.: Biochim.Biophys.Acta 416 (1975) 53–103.CrossRefGoogle Scholar
  3. [3]
    Mitchell, P.: Biochem.Soc.Trans. 4 (1976) 399–430.Google Scholar
  4. [4]
    Mcholls, D.G.: Ear. J. Biochem. 49 (1974) 573–583.CrossRefGoogle Scholar
  5. [5]
    Mcholls, D.G.: Ear. J. Biochem. 62 (1976) 223–228.CrossRefGoogle Scholar
  6. [6]
    Mcholls, D.G.: FEBS Lett. 61 (1976) 103–110.CrossRefGoogle Scholar
  7. [7]
    Nicholls, D.G. and Bernson, V.S.M.: Ear. J. Biochem. (in press).Google Scholar
  8. [8]
    Nicholls, D.G. and Lindberg, O.: Ear. J. Biochem. 37 (1973) 523–530.CrossRefGoogle Scholar

Copyright information

© Springer Basel AG 1978

Authors and Affiliations

  • David G. Nicholls
    • 1
  • Vibeke S. M. Bernson
    • 2
  • Gillian M. Heaton
    • 1
  1. 1.Departments of Psychiatry and Biochemical Medicine, Ninewells Medical SchoolDundee UniversityDundeeScotland, UK
  2. 2.Wennergrens InstitutStockholm UniversitetStockholmSweden

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