Abstract
Lactate production has often been studied in the past by means of plasma concentration measurements. This method produces interesting information in cases of sudden large rises in lactacidemia, i.e., when the intensity of the muscular exercise is great enough to induce a lactate production exceeding by far the possibilities of removal. However, such exercises are of short duration, and this method is inadequate for prolonged physical exercises, in which lactacidemia remains fairly constant at low or moderate levels. Such situations have been observed in various species (man, dog) and with various types of muscular activity (running, skiing, cycling), including shivering [1, 2, 8, 10, 11, 15, 21, 22].
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References
Astrand, P. O., Hallback, I., Hedman, R. and Saltin, B.: Blood lactates after prolonged severe exercise. J. appl. Physiol. 18, 619–622 (1963).
Bang, O.: The lactate content of the blood during and after muscular exercise in man. Scand. Arch. Physiol. 74, suppl. 10, 49–82 (1936).
Berry, M. N. and Scheuer, J.: Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock. Metabolism 16, 537–547 (1967).
Brooks, G. A., Brauner, K. E. and Cassens, R. G.: Glycogen synthesis and metabolism of lactic acid after exercise. Amer. J. Physiol. 224, 1162–1166 (1973).
Chance, B., Pye, K. and Higgins, J.: Waveform generation by enzymatic oscillators. I.E.E.E. spectrum 4, 79–86 (1967).
Corsi, A., Zatti, M., Midrio, M. and Granata, A. L.: In situ oxidation of lactate by skeletal muscle during intermittent exercise. F.E.B.S. letters 11, 65–68 (1970).
Depocas, F. and DE Freyas, A. S. W.: Method for estimating rates of formation and interconversion of glucose — glycerol and glucose — lactic acid in intact animals. Canad. J. Physiol. Pharmacol. 48, 557–560 (1970).
Depocas, F., Minaire, Y. and Chatonnet, J.: Rates of formation and oxidation of lactic acid in dogs at rest and during moderate exercise. Canad. J. Physiol. Pharmacol. 47, 603–610 (1969).
Freminet, A., Bursaux, E. and Poyart, C. F.: Mesure de la vitesse de renouvellement du lactate chez le rat par perfusion de 14-C-U (L) lactate. Pflügers Arch. 334, 293–302 (1972).
Hems, R., Ross, B. D., Berry, M. N. and Krebs, H. A.: Gluconeogenesis in the perfused rat liver. Biochem. J. 101, 284–292 (1966).
Hubbard, J.L.: The effect of exercise on lactate metabolism. J. Physiol., Lond. 231, 1–18 (1973).
Issekurz, B. jr., Allen, M. and Borkow, I.: Estimation of glucose turnover in the dog with glucose-2-T and glucose-U-14C. Amer. J. Physiol. 222, 710–712 (1972).
Josses, F. F. and Stainsby, M.N.: Oxidation of Nadh during contractions of circulated mammalian skeletal muscle. Resp. Physiol. 4, 292–300 (1968).
Jorfeldt, L.: Metabolism of L (+) lactate in human skeletal muscle during exercise. Acta Physiol. scand., suppl. 338, 5–67 (1970).
Karlsson, J.: Lactate in working muscles after prolonged exercise. Acta physiol. scand. 82, 123–130 (1971).
Keul, J., Doll, E. and Keppler, D.: Energy metabolism of human muscle (S. Karger, Basel 1972 ).
Margaria, R., Cerretelli, P., DI Prampero, P. E., Massari, C. and Torelli, G.: Kinetics and mechanism of oxygen debt contraction in man. J. appl. Physiol. 18, 371–377 (1963).
Minaire, Y.: Origine et destinée du lactate plasmatique. J. Physiol. (Paris), 66, 229–257 (1973).
Minaire, Y., Pernod, A., Jomain, M. J. and Mottaz, M.: Lactate turnover and oxidation in normal and adrenal-demedullated dogs during cold exposure. Canad. J. Physiol. Pharmacol. 49, 1063–1070 (1971).
Omachi, A. and Lifson, N.: Metabolism of isotopic lactate by the isolated perfused dog gastrocnemius. Amer. J. Physiol. 158, 35–40 (1956).
Rowell, L. B., Kraning II, K. K., Evans, T. O., Kennedy, J. W., Blackmon, J. R. and Kusami, F.: Splanchnic removal of lactate and pyruvate during prolonged exercise in man. J. appl. Physiol. 21, 1773–1783 (1966).
Schmitt, M., Vettes, B., Minaire, Y. and Ronsin, J. C.: Etude de la dépense énergétique et de la lactacidémie au cours du travail musculaire et du frisson thermique. C. R. Soc. Biol. 158, 770–773 (1964).
Searle, G. L., Strisower, E. H. and Chaikoff, T. L.: Determination of rates of glucose oxidation in normal and diabetic dogs by a technique involving continuous injection of 14C glucose. Amer. J. Physiol. 185, 589–594 (1956).
Steele, R., Altszuler, N., Wall, J. S., Dunn, A. and DE Bodo, R. C.: Influence of adrenalectomy on glucose turnover and conversion to CO2: studies with 14 C glucose in the dog. Amer. J. Physiol. 196, 221–230 (1959).
Steele, R., Wall, J. S., DE BoDo, R. C. and Altszuler, N.: Measurement of the size and turnover rate of the body glucose pool by isotope dilution. Amer. J. Physiol. 187, 15–24 (1956).
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Minaire, Y., Forichon, J. (1975). Lactate Metabolism and Glucose Lactate Conversion in Prolonged Physical Exercise. In: Howald, H., Poortmans, J.R. (eds) Metabolic Adaptation to Prolonged Physical Exercise. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5523-5_12
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DOI: https://doi.org/10.1007/978-3-0348-5523-5_12
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