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The Biliary Excretion and Enterohepatic Circulation of Drugs and Other Organic Compounds

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Fortschritte der Arzneimittelforschung \ Progress in Drug Research \ Progrès des recherches pharmaceutiques

Part of the book series: Progress in Drug Research ((PDR,volume 9))

Abstract

The biological activity of drugs in the body is usually terminated by a combination of the processes of metabolism and excretion. The metabolic changes undergone by drugs in vivo are in general directed to the formation of metabolites which have physico-chemical properties favourable for their rapid elimination from the body. The final products of metabolism, or de-toxication products, are usually highly polar and these behave as efficient substrates for the transfer mechanisms functioning in the excretory organs. Furthermore, the polarity of the metabolites tends to confine them to the extra-cellular fluid, another factor conducive to their rapid elimination.

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  1. Department of Biochemistry, St. Mary’s Hospital Medical School, London, W2, Great Britain

    Robert L. Smith

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  1. Basel, Schweiz

    Ernst Jucker

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Smith, R.L. (1966). The Biliary Excretion and Enterohepatic Circulation of Drugs and Other Organic Compounds. In: Jucker, E. (eds) Fortschritte der Arzneimittelforschung \ Progress in Drug Research \ Progrès des recherches pharmaceutiques. Progress in Drug Research, vol 9. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-4021-7_5

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