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IL-17 Receptor Family: Structure, Signal Transduction, and Function

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Since the discovery of a unique population of T helper cells which secrete interleukin 17 (IL-17), IL-17 is no longer viewed as “yet-another interleukin” but stands out as a unique cytokine in host defense and autoimmunity. To date, the IL-17 cytokine family has been expanded to six members: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F. They elicit overlapping and yet divergent functions through different receptors. IL-17 receptor family currently consists of five members: IL-17RA, IL-17RB, IL-17RC, IL-17RD, and IL-17RE. They are type I transmembrane proteins that tend to form heteromeric receptor complexes on cell surface. This chapter will cover recent update on structure, signaling pathway, and function of IL-17 receptor family.

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Acknowledgments

Thanks David Shealy, Wenjun Ouyang, Joel Tocker, Sarah Gaffen, Murray McKinnon, and Merle Elloso for critical reviewing of the manuscript.

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  1. Immunology, Janssen Research and Development, 145 King of Prussia Road, Radnor, PA, 19087, USA

    Fang Shen

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  1. Fang Shen
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  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Shen, F. (2013). IL-17 Receptor Family: Structure, Signal Transduction, and Function. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_3

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