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Lentiviral Vectors and Gene Therapy pp 11–28Cite as

Development of Retroviral and Lentiviral Vectors

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Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

Abstract

Gene vectors based on human immunodeficiency virus 1 (HIV-1) are becoming popularly used as gene carriers. HIV-1 lentivectors have recently been used in two gene therapy clinical trials for the correction of β-thalassaemia and X-linked adrenoleukodystrophy. The process of transforming a deadly human pathogen such as HIV into a successful therapeutic tool would not be possible without thorough scientific investigation into the development of γ-retrovirus vectors. In this chapter, we briefly recapitulate the major scientific steps that have led to the development of γ-retrovirus and lentivirus vectors.

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Acknowledgments

David Escors is funded by an Arthritis Research UK Career Development Fellowship (18433). Holly Stephenson is funded by the Biomedical Research Centre, Institute of Child Health, UCL. Karine Breckpot is funded by the Fund for Scientific Research-Flandes. The Oxford Structural Genomics Consortium is a registered UK charity (number 1097737) that receives funds from the Canadian Institutes of Health Research, The Canadian Foundation for Innovation, Genome Canada through the Ontario Genomics Institute, GlaxoSmithKline, Karolinska Institutet, the Knut and Alice Wallenberg Foundations, the Ontario Innovation Trust, the Ontario Ministry for Research and Innovation, Merck & Co., Inc., the Novartis Research Foundation, the Swedish Foundation for Strategic Research and the Wellcome Trust.

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Authors and Affiliations

  1. University College London, Rayne Building, 5 University Street, London, WC1E 6JF, UK

    David Escors

  2. Oxford Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK

    Grazyna Kochan

  3. Institute of Child Health, University College London, Great Ormond Street, London, WC1N 3JH, UK

    Holly Stephenson

  4. Vrije Universiteit Brussels, Brussels, Belgium

    Karine Breckpot

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  1. David Escors
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  2. Grazyna Kochan
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  3. Holly Stephenson
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  4. Karine Breckpot
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Correspondence to David Escors .

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Escors, D., Kochan, G., Stephenson, H., Breckpot, K. (2012). Development of Retroviral and Lentiviral Vectors. In: Lentiviral Vectors and Gene Therapy. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Basel. https://doi.org/10.1007/978-3-0348-0402-8_2

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