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rHuG-CSF for the Treatment of Severe Chronic Neutropenia

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Book cover Twenty Years of G-CSF

Part of the book series: Milestones in Drug Therapy ((MDT))

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Abstract

Severe chronic neutropenia (SCN) is a general term used to describe patients with blood neutrophil counts either chronically or cyclically less than 500 neutrophils per cubic millimeter (i.e., <0.5 × 109/L). Many causes for this condition are known, both hereditary and acquired diseases. The common feature is that low blood neutrophil counts predispose patients to develop fever, ulcerations along the gastrointestinal tract from the mouth to the anus, and recurrent infections.

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Acknowledgments

The authors express appreciation to the Advisory Board members and staff of the SCNIR and referring physicians, patients, and families for contributing to the data for this report. We also express appreciation to Laurie Steele and to Amgen and the NIH/NIAID (# 5R 24AI049393) for their support.

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Authors and Affiliations

  1. Division of General Internal Medicine, University of Washington, 1959 NE Pacific St, AA 522 Health Sciences Building, 356422, Seattle, WA, 98195, USA

    David C. Dale

  2. Division of General Internal Medicine, University of Washington, 356422, Seattle, WA, USA

    Audrey Anna Bolyard

Authors
  1. David C. Dale
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  2. Audrey Anna Bolyard
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Corresponding author

Correspondence to David C. Dale .

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Editors and Affiliations

  1. Amgen Inc., One Amgen Center Drive, Thousand Oaks, 91320, California, USA

    Graham Molineux

  2. MA Foote Associates, Par Five Court 4284, Westlake Village, 91362, California, USA

    MaryAnn Foote

  3. Amgen, Inc., One Amgen Center Dr. 1, Thousand Oaks, 91320, California, USA

    Tara Arvedson

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Dale, D.C., Bolyard, A.A. (2012). rHuG-CSF for the Treatment of Severe Chronic Neutropenia. In: Molineux, G., Foote, M., Arvedson, T. (eds) Twenty Years of G-CSF. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0218-5_15

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