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Galanin pp 51-59 | Cite as

Galanin Family of Peptides in Skin Function

  • J. W. Bauer
  • R. Lang
  • M. Jakab
  • B. KoflerEmail author
Chapter
Part of the Experientia Supplementum book series (EXS, volume 102)

Abstract

The skin, the largest organ of the body, functions as a barrier between the body proper and the external environment, as it is constantly exposed to noxious stressors. During the last few years, the concept of an interactive network involving cutaneous nerves, the neuroendocrine axis, and the immune system has emerged. The neuroendocrine system of the skin is composed of locally produced neuroendocrine mediators that interact with specific receptors. Among these mediators are neuropeptides, including members of the galanin peptide family – galanin, galanin-message associated peptide, galanin-like peptide, and alarin – which are produced in neuronal as well as nonneuronal cells in the skin. Here, we review the expression of the galanin peptides and their receptors in the skin, and the known functions of galanin peptides in different compartments of the skin. We discuss these data in light of the role of the galanin peptide family in inflammation and cell proliferation.

Keywords

Galanin Galanin receptor Inflammation Innate immunity Skin 

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of DermatologySALK and Paracelsus Medical University SalzburgSalzburgAustria
  2. 2.Institute of Physiology and PathophysiologySALK and Paracelsus Medical University SalzburgSalzburgAustria
  3. 3.Department of PediatricsSALK and Paracelsus Medical University SalzburgSalzburgAustria

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