Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming

Immunosenescence and Its Correction
  • Wayne A. MitchellEmail author
  • Ryan C. Pink
  • Antonio Lapenna
  • Richard Aspinall
Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)


One of the hallmarks of ageing is the increased susceptibility to develop age-related diseases such as infections and cancers. This is believed to be favoured by a decline in the function of the innate and adaptive immune systems, a process known as immunosenescence. The current greying of the world population leads to the potential dilemma of increasing life expectancy without the concomitant increase in the quality of life with more individuals acquiring age-related disorders. Ultimately this may have profound socio-economic implications for those in positions of government and strategic policy makers. With this in mind, this chapter reviews the current understanding of some of the causes of immunosenescence and looks to address the question, “Can immunosenescence be corrected or reversed?”


Nerve Growth Factor Telomere Length Graft Versus Host Disease Haematopoietic Stem Cell Transplant Keratinocyte Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Wayne A. Mitchell
    • 1
    Email author
  • Ryan C. Pink
    • 1
  • Antonio Lapenna
    • 1
  • Richard Aspinall
    • 1
  1. 1.Department of Translational Medicine, Cranfield HealthCranfield UniversityBedfordshireUK

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