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A5 Cytokines

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Abstract

In immune responses several cell types have to cooperate. Within the LYMPHOID ORGANS, such as lymph nodes, spleen or PEYER’S PATCHES, the cells of the IMMUNE SYSTEM interact in a dynamic fashion. At all times some cells, especially T LYMPHOCYTES, leave a lymphoid organ (such as a lymph node), circulate through the body and enter another lymphoid organ in search of a fitting antigen. As a consequence, the communication between the cells of the immune SYSTEM – LYMPHOCYTES, monocytic cells and GRANULOCYTES – depends on secreted diffusible mediators, the most important of which are the cytokines.

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References

  1. Vilcek J (2003) The cytokines: an overview. In: AW Thomson, M Lotze (eds): The Cytokine Handbook, 4th edn. Academic Press, London, 3–18

    Google Scholar 

  2. Leonard WJ (2008) Type I cytokines and interferons and their receptors. In: WE Paul (ed): Fundamental Immunology, 6th edn. Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 706–749

    Google Scholar 

  3. Dinarello CA (2008) Interleukin-1 family of ligands and their receptors. In: WE Paul (ed): Fundamental Immunology, 6th edn. Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 750–775

    Google Scholar 

  4. Wang X, Lupardus P, LaPorte SL Garcia KC (2009) Struc- tural biology of shared cytokine receptors. Annu Rev Immunol 27: 29–60

    Article  PubMed  Google Scholar 

  5. Wickrema A, Klee B (eds) (2009) Molecular Basis of Hematopoesis. Springer, Heidelberg

    Google Scholar 

  6. Smith TJ, Khatcheressian J, Lyman GH et al (2006) Update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 24: 3187–3205

    Article  PubMed  CAS  Google Scholar 

  7. Elliott SG, Foote MA, Molineux G (eds) (2009) Erythropoietins, Erythropoietic Factors and Erythropoiesis; Milestones in Drug Therapy, 2nd edn. Birkhauser, Basel

    Google Scholar 

  8. Kuter DJ (2009) Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med 60: 193–206

    Article  PubMed  CAS  Google Scholar 

  9. Rothenberg EV (2007) Cell lineage regulators in B and T cell development. Nat Immunol 8: 441–444

    Article  PubMed  CAS  Google Scholar 

  10. Stavnezer J, Guikema JEJ, Schrader CE (2008) Mechanism and regulation of class switch recombination. Annu Rev Immunol 26: 261–292

    Article  PubMed  CAS  Google Scholar 

  11. Smith-Garvin JE, Koretzky GA, Jordan MA (2009) T cell activation. Annu Rev Immunol 27: 591–619

    Article  PubMed  CAS  Google Scholar 

  12. Malek TR (2008) The biology of interleukin 2. Annu Rev Immunol 26: 453–479

    Article  PubMed  CAS  Google Scholar 

  13. Commins S, Steinke JW, Borish L (2008) The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL24, IL-26, IL 28, IL-29. J Allergy Clin Immunol 121: 1108–1111

    Article  PubMed  CAS  Google Scholar 

  14. Dong C (2008) Regulation and proinflammatory function of interleukin-17 family cytokines. Immunol Rev 226: 80–86

    Article  PubMed  CAS  Google Scholar 

  15. Ettinger R, Kuchen S, Lipsky PE (2008) The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev 223: 60–86

    Article  PubMed  CAS  Google Scholar 

  16. Langrish CL, McKenzie BS, Wilson NJ de Waal Malefyt R, Kasteleine RA, Cua DJ (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 202: 96–105

    Article  PubMed  CAS  Google Scholar 

  17. Barlow JL, McKenzie AN (2009) IL-25: a key requirement for the regulation of type-2 immunity. Biofactors 35: 178–182

    Article  PubMed  CAS  Google Scholar 

  18. Yoshida H, Nakaya M, Miyazaki Y (2009) Interleukin-27: a double edged sword for offense and defense. J Leukoc Biol 86: 1295–1303

    Article  PubMed  CAS  Google Scholar 

  19. Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W et al (2008) Structures and biological functions of IL-31 and IL-31 receptors. Cytokine Growth Factor Rev 19: 347–356

    Article  PubMed  Google Scholar 

  20. Dinarello CA, Kim SH (2006) IL-32, a novel cytokinewith a possible role in disease. Ann Rheum Dis 65, supp l3: iii 61–64

    Google Scholar 

  21. Smith DE (2010) IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma. Clin Exp Immunol 40: 200–208

    CAS  Google Scholar 

  22. Garceau V, Smith J, Paton IR, Davey M, Fares MA, Sester DP et al (2010) Pivotal advance: avian colony-stimulationg factor 1 (CSF 1), interleukin-34, and CSF-1 receptor genes and gene products. J Leukoc Biol 87: 753–764

    Article  PubMed  CAS  Google Scholar 

  23. Collison LW, Vignali DA (2008) Interleukin-35: odd one out or part of the family? Immunol Rev 226: 248–262

    Article  PubMed  CAS  Google Scholar 

  24. D’Acquisto F, Maione F, Pederzoli-Ribeil M (2010) From IL-15 to IL-33: the never ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead? Biochem Pharmacol 79: 525–534

    Article  PubMed  Google Scholar 

  25. Dale DC, Boxer L, Liles WC (2008) The phagocytes: neutrophils and monocytes. Blood 112: 935–945

    Article  PubMed  CAS  Google Scholar 

  26. Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454: 428–435

    Article  PubMed  CAS  Google Scholar 

  27. Nathan C (2002) Points of control in inflammation. Nature 420: 846–852

    Article  PubMed  CAS  Google Scholar 

  28. Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8: 559–568

    Article  PubMed  CAS  Google Scholar 

  29. Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, Stark GR (2007) Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 6: 975–990

    Article  PubMed  CAS  Google Scholar 

  30. Ware CF (2008) TNF-related cytokines in inflammation. In: WE Paul (ed): Fundamental Immunology, 6th edn. Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 776–803

    Google Scholar 

  31. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27: 519–550

    Article  PubMed  CAS  Google Scholar 

  32. Ding C, Ciccutini F, Li J, Jones G (2009) Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert Opin Investig Drugs 18: 1457–1466

    Article  PubMed  CAS  Google Scholar 

  33. Bermel R, Weinstock-Guttman B, Bourdette D, Foulds P, You X, Rudick R et al (2010) Intramuscular interferon beta-1a therapy in patients with relapsing-remitting multiple sclerosis: a 15-year follow-up study. Mult Scler 16: 588–596

    Article  PubMed  CAS  Google Scholar 

  34. Goldman JM (2009) Treatment strategies for CML. Best Pract Res Clin Haematol 22 : 303–13

    Article  PubMed  CAS  Google Scholar 

  35. Chavez AR, Buchser W, Basse PH, Liang X, Appleman LJ, Maranchie JK et al (2009) Pharmacologic administration of interleukin-2. Ann NY Acad Sci 1182: 14–27 t

    Google Scholar 

  36. de Vries MR, ten Hagen TL, Marinelli AW, Eggermont AM (2003) Tumor necrosis factor and isolated hepatic perfusion: from preclinic tumor models to clinical studies. Anticancer Res 23: 1811–1823

    PubMed  Google Scholar 

  37. Kircheis R, Ostermann E, Wolschek MF, Lichtenberger C, Magin-Lachmann C, Wightman L et al (2002) Tumortargeted gene delivery of tumor necrosos factor-alpha induces tumor necrosis and tumor regression without systemic toxicity. Cancer Gene Ther 9: 673–680

    Article  PubMed  CAS  Google Scholar 

  38. Griffin JD (2001) Hematopoietic growth factors. In: VT DeVita, S Hellman, SA Rosenberg (eds): Cancer Principles and Practice of Oncology. Lippincott/Williams and Wilkins, Philadelphia, 2798–2813

    Google Scholar 

  39. Fischer M, Goldschmitt J, Peschel C, Brakenhoff, Kallen KJ, Wollmer A et al (1997) A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 15: 142–145

    Article  PubMed  CAS  Google Scholar 

  40. Mosmann TR, Sal S (1996) The expanding universe of T-subsets: Th1, Th2 and more. Immunol Today 17: 138–146

    Article  PubMed  CAS  Google Scholar 

  41. Fietta P, Delsante G (2009) The effector T helper tiade. Riv Biol 102: 61–74

    PubMed  Google Scholar 

  42. Betteli E, Korn T, Oukka M, Kuchroo VK (2008) Induction and effector functions of TH17 cells. Nature 453: 1052–1057

    Article  Google Scholar 

  43. Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3: 253–257

    Article  PubMed  CAS  Google Scholar 

  44. Vignale DAA, Collison LW, Workman CJ (2008) How regulatory T cells work. Nat Rev Immunol 8: 523–531

    Article  Google Scholar 

  45. Sallusto F, Baggiolini M (2008) Chemokines and leukocyte traffic. Nat Immunol 9: 949–952

    Article  PubMed  CAS  Google Scholar 

  46. Bromley SK, Mempel TR, Luster AD (2008) Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 9: 970–980

    Article  PubMed  CAS  Google Scholar 

  47. Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4: 540–550

    Article  PubMed  CAS  Google Scholar 

  48. Wells TNC, Power CA, Shaw FP, Proudfoot AEI (2006) Chemokine blockers-therapeutics in the making? Trends Pharmacol Sci 27: 1–17

    Article  Google Scholar 

  49. Mackay CR (2008) Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol 9: 988–998

    Article  PubMed  CAS  Google Scholar 

  50. Mantovani A, Dinarello CA, Ghezzi P (2000) Pharmacology of cytokines. Oxford University Press, Oxford

    Google Scholar 

  51. Giliberto G, Savino R (2001) Cytokine Inhibitors. Marcel Dekker, New York

    Google Scholar 

  52. Feldmann M (2009) Translating molecular insights in autoimmunity into effective therapy. Annu Rev Immunol 27: 1–27

    Article  PubMed  CAS  Google Scholar 

  53. Taylor PC, Feldmann M (2009) Anti-TNF biologic agents: still the therapy of choice in rheumatoid arthritis. Nat Rev Rheumatol 5: 578–582

    Article  PubMed  CAS  Google Scholar 

  54. Dinarello CA (2009) Inflammation in human disease: anticytokine therapy. Biol Blood Marrow Transplant 15 (Suppl): 134–136

    Article  PubMed  CAS  Google Scholar 

  55. Daridon C, Burmester GR, Dorner T (2009) Anticytokine therapy impacting on B cells in autoimmune diseases. Curr Opin Rheumatol 21: 205–210

    Article  PubMed  CAS  Google Scholar 

  56. Liberman AC, Druker J, Perone MJ, Arzt E (2007) Glucocorticoids in the regulation of transcription factors that control cytokine synthesis. Cytokine Growth Factor Rev 18: 45–56

    Article  PubMed  CAS  Google Scholar 

  57. Braat H, Peppelenbosch MP, Hommes DW (2003) Interleukin-10 based therapy for inflammatory bowel disease. Expert Opin Biol Ther 3: 725–731

    Article  PubMed  CAS  Google Scholar 

  58. O’Neill LA (2006) Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov 5: 549–563

    Article  PubMed  Google Scholar 

  59. Gaestel M, Kotlyarov A, Kracht M (2009) Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov 8: 480–4991

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany

    Klaus Resch

  2. Institut für Immunologie, Justus-Liebig-Universität Giessen, Winchesterstrasse 2, 35394, Giessen, Germany

    Michael U. Martin

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  1. Klaus Resch
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  2. Michael U. Martin
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Correspondence to Klaus Resch .

Editor information

Editors and Affiliations

  1. Faculteit Farmacie, Rijksuniversiteit Utrecht, Utrecht, Netherlands

    F.P. Nijkamp

  2. Diseases "Dr. Fran Mihaljevic", Research & Clinical Immunology Unit, University Hospital for Infectious, Mirogojska cesta 8, Zagreb, 10000, Croatia

    Michael J. Parnham

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© 2011 Birkhäuser Basel

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Resch, K., Martin, M.U. (2011). A5 Cytokines. In: Nijkamp, F., Parnham, M. (eds) Principles of Immunopharmacology. Birkhäuser Basel. https://doi.org/10.1007/978-3-0346-0136-8_5

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