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Use Case: Stent Biodegradation Modeling

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Abstract

This chapter provides an extensive exploration of the evolving landscape of stent technology, with a specific focus on the development and implications of biodegradable stents in cardiology. Traditional stent therapies, primarily metallic and drug-eluting stents, have been instrumental in treating coronary artery diseases but pose long-term complications, such as in-stent restenosis and the necessity of permanent implantation. The advent of biodegradable stents marks a significant advancement, offering a solution to these challenges by introducing materials that safely dissolve within the body after serving their purpose.

The chapter delves into the materials used in biodegradable stents, including polymers like polylactic acid (PLA) and polyglycolic acid (PGA), and bioresorbable metals such as magnesium and iron alloys. Each material’s unique properties, degradation mechanisms, and interactions with the biological environment are examined. The role of hydrolysis, enzymatic degradation, and corrosion in the biodegradation process is discussed in detail, emphasizing the interplay between material properties and biodegradation.

Furthermore, the chapter highlights the use of advanced mathematical and computational models in predicting stent degradation behavior. These models are crucial for designing stents that are not only effective in the short term but also safe and beneficial in the long term. The chapter concludes with a discussion on the clinical implications of biodegradable stents, including their impact on patient outcomes, and speculates on future directions, such as drug-eluting capabilities and personalized stent designs. This comprehensive overview encapsulates the current state and exciting future of biodegradable stent technology in cardiovascular medicine.

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Authors and Affiliations

  1. Institute for Information Technologies Kragujevac, University of Kragujevac, Kragujevac, Serbia

    Dalibor D. Nikolić

  2. Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia

    Nenad Filipović

  3. Bioengineering Research and Development Center (BioIRC), Kragujevac, Serbia

    Nenad Filipović

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  1. Dalibor D. Nikolić
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  2. Nenad Filipović
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Correspondence to Dalibor D. Nikolić .

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  1. Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia

    Nenad Filipović

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Nikolić, D.D., Filipović, N. (2024). Use Case: Stent Biodegradation Modeling. In: Filipović, N. (eds) In Silico Clinical Trials for Cardiovascular Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-60044-9_11

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