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Importance of Vitamin E and Its Metabolism for Health and Disease

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Lipophilic Vitamins in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 28))

Abstract

Vitamin E was discovered as ‘factor X’, which has an essential function in rodent fertility. Later, it was attributed an important role as an antioxidant, and until today, vitamin E is still considered one of the most important antioxidants in human nutrition. Over the last 100 years of vitamin E research, it has been shown that this fat-soluble vitamin has a variety of important functions in the metabolism of animals and humans. Several in vitro and in vivo studies on vitamin E, or its derivatives and metabolites, demonstrate its essentiality for membrane integrity, anti-oxidative and anti-inflammatory properties as well as neuroprotection. Thus, vitamin E plays an important role in various diseases. In this article we provide an overview of the function and metabolism of vitamin E and its importance for the prevention, progression, and therapy of cardiometabolic and inflammatory diseases as well as the rare disease termed ataxia with vitamin E deficiency (AVED), which is caused by mutations in the gene encoding for the α-tocopherol transfer protein (α-TTP). We focus on the role of vitamin E in cardiovascular diseases (CVD), non-alcoholic fatty liver disease (NAFLD) and skin health.

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Funding

M.W. and S.L. were supported by the Free State of Thuringia and the European Social Fund (2019 FGR 0095). Work of M.W. was supported by the IMPULSE (DRM/2019-01). Other sources of funding include the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1411A).

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Authors and Affiliations

  1. Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany

    Lisa Börmel, Anja R. Geisler, Stefan Lorkowski & Maria Wallert

  2. Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany

    Lisa Börmel, Anja R. Geisler, Stefan Lorkowski, Maria Wallert & Maria Wallert

Authors
  1. Lisa Börmel
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  2. Anja R. Geisler
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  3. Stefan Lorkowski
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  4. Maria Wallert
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Contributions

Conceptualization: L.B. and M.W.; writing original draft preparation: L.B., A.G., M.W.; writing review and editing: L.B., A.G., M.W. and S.L.; visualization: L.B., A.G.; supervision: M.W. and S.L.; project administration: M.W. and S.L.; funding acquisition: M.W. and S.L. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Maria Wallert .

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Editors and Affiliations

  1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

  2. California State University Los Angeles, Los Angeles, CA, USA

    Anureet K. Shah

  3. Institute of Cardiovascular Science, St. Boniface Hospital, Winnipeg, MB, Canada

    Naranjan S. Dhalla

Ethics declarations

M.W. and S.L. have received a research grant from DSM Nutritional Products GmbH. The funder had no role in the design of the study; interpretation of data; in the writing of the manuscript; or in the decision to publish the manuscript. The remaining authors declare no conflicts of interest.

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Börmel, L., Geisler, A.R., Lorkowski, S., Wallert, M. (2024). Importance of Vitamin E and Its Metabolism for Health and Disease. In: Tappia, P.S., Shah, A.K., Dhalla, N.S. (eds) Lipophilic Vitamins in Health and Disease. Advances in Biochemistry in Health and Disease, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-031-55489-6_9

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