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Vitamin E for the Prevention and Treatment of Cardiovascular Disease

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Lipophilic Vitamins in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 28))

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Abstract

Cardiovascular disease (CVD) is a major health and economic concern worldwide. Vitamins are considered to be of great importance for maintaining cardiovascular function in health and disease. A deficiency of the antioxidant vitamin E has been linked to an increase in the risk of CVD and oxidative stress is one of the main factors in the pathogenesis of this disorder. However, despite several lines of experimental evidence, observational and interventional studies have yielded inconclusive and conflicting data. Accordingly, in this article, it is intended to discuss the controversies regarding the actions of vitamin E in cardiovascular health and disease, and describe the beneficial role of vitamin E in protection against cardiovascular complications in diabetes. It is suggested that the clinical efficacy of vitamin E in preventing the development of CVD may only be observed in specific patient populations.

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Acknowledgements

We thank the St. Boniface Hospital Albrechtsen Research Centre for providing the infrastructural support for this project.

Author information

Authors and Affiliations

  1. Asper Clinical Research Institute, CR3129-369 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada

    Shirley C. Fitzpatrick-Wong & Paramjit S. Tappia

  2. St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada

    Shirley C. Fitzpatrick-Wong & Paramjit S. Tappia

  3. Institute of Cardiovascular Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Naranjan S. Dhalla

  4. Department of Physiology and Pathophysiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Naranjan S. Dhalla

Authors
  1. Shirley C. Fitzpatrick-Wong
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  2. Paramjit S. Tappia
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  3. Naranjan S. Dhalla
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Corresponding author

Correspondence to Paramjit S. Tappia .

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Editors and Affiliations

  1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

  2. California State University Los Angeles, Los Angeles, CA, USA

    Anureet K. Shah

  3. Institute of Cardiovascular Science, St. Boniface Hospital, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Fitzpatrick-Wong, S.C., Tappia, P.S., Dhalla, N.S. (2024). Vitamin E for the Prevention and Treatment of Cardiovascular Disease. In: Tappia, P.S., Shah, A.K., Dhalla, N.S. (eds) Lipophilic Vitamins in Health and Disease. Advances in Biochemistry in Health and Disease, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-031-55489-6_11

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