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The Cardio-protective Effect of Fat-Soluble Vitamins on Anti-cancer Drug Induced Cardiotoxicity

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Lipophilic Vitamins in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 28))

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Abstract

Anti-tumor medications like chemotherapies fall into the class of drugs referred to as anthracyclines. These anthracyclines, while powerful and effective in dealing with tumor growth have a degenerative effect on the cardiovascular system. Many cancer patients suffer from cardiomyopathy years after treatment with these drugs have been halted. However, an overwhelming number of patients still succumb to heart disease after surviving their initial bouts with cancer. An overwhelming amount of peer-reviewed research has looked into the use of fat-soluble vitamins specifically D and E as possible protectors of the heart in patients being treated with anthracycline. Vitamin D and E have been shown to have a significant statistical effect on many biomarkers that are affected by anthracycline cardiotoxicity. Both fat-soluble vitamins show a potential significant clinical effect that merits a further investigation in order to understand the mechanisms and pathways responsible for anthracycline mediated cardiotoxicity and possible routes to cardio protection.

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Acknowledgements

Our sincere thanks to Ms. Gurnoor Kaur, a diligent high school student, for the formatting of this manuscript in APA 7th edition, ensuring that the document adhered to the required formatting guidelines.

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Authors and Affiliations

  1. Department of Nutrition and Food Science, California State University Los Angeles, Los Angeles, CA, USA

    Jamie S. Duarte, Anureet K. Shah & Anureet K. Shah

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  1. Jamie S. Duarte
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Correspondence to Anureet K. Shah .

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  1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

  2. California State University Los Angeles, Los Angeles, CA, USA

    Anureet K. Shah

  3. Institute of Cardiovascular Science, St. Boniface Hospital, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Duarte, J.S., Shah, A.K. (2024). The Cardio-protective Effect of Fat-Soluble Vitamins on Anti-cancer Drug Induced Cardiotoxicity. In: Tappia, P.S., Shah, A.K., Dhalla, N.S. (eds) Lipophilic Vitamins in Health and Disease. Advances in Biochemistry in Health and Disease, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-031-55489-6_1

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