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Interaction of Low Voltage Microplasma Discharge with Stratum Corneum

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Recent Advances in Technology Research and Education (Inter-Academia 2023)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 939))

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Abstract

Number of transdermal patches is growing ever year. However, not every drug is possible deliver through the skin effectively. This creates pressure on searching a new method able to deliver drugs transdermal pathway. One of such methods is treatment of the skin by device producing plasma affecting barrier function of the skin. In our study, permeability of sodium fluorescein through the most upper part of the skin, stratum corneum was demonstrated. Permeability of stratum corneum was enhanced by argon microplasma treatment or air microplasma treatment. Lipid oxidation inside stratum corneum was proved by presence of lipid peroxides using fluorescent dye LiperFluo by performing a frozen section of the full thickness skin. FTIR measurement showed correlation between lipid disordered structures in lipid matrix of stratum corneum and presence of lipid peroxides.

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Authors and Affiliations

  1. Organization for Innovative and Social Collaboration, Shizuoka University, Hamamatsu, 432-8011, Japan

    Jaroslav Kristof & Kazuo Shimizu

  2. Graduate School of Integrated Science and Technology, Shizuoka University, Hamamatsu, 432-8011, Japan

    Marium Maliha & Kazuo Shimizu

  3. Graduate School of Science and Technology, Shizuoka University, Hamamatsu, 432-8011, Japan

    Sadia Afrin Rimi, Abubakar Hamza Sadiq, Yoshinori Mizuno & Kazuo Shimizu

  4. Graduate School of Medical Photonics, Shizuoka University, Hamamatsu, 432-8011, Japan

    Alam Md Jahangir & Kazuo Shimizu

  5. Research and Development Center, Asahikogyosha Co. Ltd., Narashino, 275-0001, Japan

    Yoshinori Mizuno

Authors
  1. Jaroslav Kristof
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  2. Marium Maliha
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  3. Sadia Afrin Rimi
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  4. Abubakar Hamza Sadiq
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  5. Alam Md Jahangir
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  6. Yoshinori Mizuno
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  7. Kazuo Shimizu
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Corresponding author

Correspondence to Jaroslav Kristof .

Editor information

Editors and Affiliations

  1. Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan

    Yukinori Ono

  2. Graduate School of Science and Technology, Shizuoka University, Hamamatsu, Japan

    Jun Kondoh

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Kristof, J. et al. (2024). Interaction of Low Voltage Microplasma Discharge with Stratum Corneum. In: Ono, Y., Kondoh, J. (eds) Recent Advances in Technology Research and Education. Inter-Academia 2023. Lecture Notes in Networks and Systems, vol 939. Springer, Cham. https://doi.org/10.1007/978-3-031-54450-7_12

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