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System Biology Research to Advance the Understanding of Canine Cancer

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Sustainable Agriculture Reviews

Part of the book series: Sustainable Agriculture Reviews ((SARV,volume 62))

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Abstract

Dogs are easy to train and have far superior olfactory abilities than humans, making them suitable for a wide range of tasks. Therapy dogs are used in psychiatric hospitals to improve the socialization and interaction of disabled patients, thereby improving their quality of life. Unfortunately, dogs have been becoming more and more susceptible to diseases, the most serious of which is cancer, in recent years. Every year, over one million new cases are reported in the United States, with an estimated mortality rate of around 30%. It is our responsibility to save the life of an animal in this situation. Canine cancers, predictably, bear an uncanny resemblance to human cancers. While dog domestication is comparable to human domestication, it opens the door to studying human cancers through the lens of dog cancer. Early detection of cancer may be advantageous for therapeutic reasons, which necessitates the development of markers that can be used as diagnostic tools due to their differential expression between disease and normal state. Pets with unexpected cancers serve as a good model for human oncology translational research. There are numerous system biology techniques that can be used to detect cancer and the biomarkers that are associated with it in its early stages. Microarray, whole-genome sequencing, whole-exome sequencing, and RNA sequencing are novel, well-organized techniques that can be applied to a wide range of applications. They will allow for high-throughput analysis of variations in DNA, mRNA, protein expression, and activity in a patient’s tumor. Therefore, in this chapter, we reviewed recent system biology applications that have been evolved to better understand life-threatening diseases such as tumors. We also described several different types of canine cancer. Biomarker identification using system biology approaches, and therapeutic intervention for canine cancer biomarkers, are presented. Additionally, we also highlight the various ways in which dogs can serve as models for cancer research.

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Abbreviations

2D-DIGE:

Two-dimensional difference gel electrophoresis

CRISPR:

Clustered Regularly Interspaced Short Palindromic Repeat

GWAS:

Genome-wide association study

MALDI-TOF-MS:

Matrix assisted laser desorption ionization-time of flight mass spectrometry

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Authors and Affiliations

  1. Cell Biology and Proteomics Lab, Animal Biotechnology Center, ICAR-NDRI, Karnal, Haryana, India

    Sonia Batan, Parul Singh & Syed Azmal Ali

  2. Division of Biochemistry, ICAR-NDRI, Karnal, Haryana, India

    Harpreet Kaur, Swasti Rawal & Deepti Mittal

  3. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia

    Gurjeet Kaur

  4. Mark Wainwright Analytical Centre, Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, Australia

    Gurjeet Kaur

  5. Steno Diabetes Center Copenhagen, Herlev, Denmark

    Gurjeet Kaur

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  1. Sonia Batan
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  2. Harpreet Kaur
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  3. Swasti Rawal
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  4. Deepti Mittal
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  5. Parul Singh
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  6. Gurjeet Kaur
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  7. Syed Azmal Ali
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Editors and Affiliations

  1. Research Centre, KBK Multispecialty Hospitals, Hyderabad, Telangana, India

    Vinod Kumar Yata

  2. ICAR-Central Institute for Research on Cattle (CIRC), Meerut, Uttar Pradesh, India

    Ashok Kumar Mohanty

  3. Xi’an Jiaotong University, Xian, China

    Eric Lichtfouse

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Batan, S. et al. (2024). System Biology Research to Advance the Understanding of Canine Cancer. In: Kumar Yata, V., Mohanty, A.K., Lichtfouse, E. (eds) Sustainable Agriculture Reviews . Sustainable Agriculture Reviews, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-031-54372-2_2

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