Abstract
This chapter contains general information about deproteinized hemoderivative of calf blood-natural botanical and mineral extracts, which have become popular in recent years. Examples of the most commonly used drugs in clinical practice, their indications for use, and clinical studies on these drugs are reviewed. The ingredients, mechanisms of action, similarities, and differences of these drugs are highlighted. Additionally, the available evidence for the use of deproteinized hemoderivative of calf blood-natural botanical and mineral extracts will be outlined, highlighting the different recommendations found in respected guidelines and highlighting conflicting findings in the literature. This chapter aims to shed light on the rationale behind the changing approaches to its use in clinical practice, highlighting the need for high-quality research to evaluate the efficacy and clinical benefits of deproteinized hemoderivative of calf blood-natural botanical and mineral extracts, particularly in muscle injuries and osteoarthritis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Järvinen TAH, Kääriäinen M, Järvinen M, Kalimo H. Muscle strain injuries. Curr Opin Rheumatol. 2000;12(2):155–61. https://doi.org/10.1097/00002281-200003000-00010.
Garrett J. Muscle strain injuries. Am J Sports Med. 1996;24(SUPPL) https://doi.org/10.1177/036354659602406S02/ASSET/036354659602406S02.FP.PNG_V03.
Harmon KG. Muscle injuries and PRP: what does the science say? Br J Sports Med. 2010;44(9):616–7. https://doi.org/10.1136/BJSM.2010.074138.
Wright-Carpenter T, Klein P, Schäferhoff P, Appell HJ, Mir LM, Wehling P. Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains. Int J Sports Med. 2004;25(8):588–93. https://doi.org/10.1055/S-2004-821304.
Kasemkijwattana C, et al. Use of growth factors to improve muscle healing after strain injury. Clin Orthop Relat Res. 2000;370(370):272–85. https://doi.org/10.1097/00003086-200001000-00028.
Abramson SB, Weissmann G. The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 1989;32(1):1–9. https://doi.org/10.1002/ANR.1780320102.
Shen W, Li Y, Tang Y, Cummins J, Huard J. NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol. 2005;167(4):1105–17. https://doi.org/10.1016/S0002-9440(10)61199-6.
Reichl FX, et al. Comprehensive analytics of Actovegin® and its effect on muscle cells. Int J Sports Med. 2017;38(11):809–18. https://doi.org/10.1055/S-0043-115738/ID/R6256-0028.
Vanden Bossche L, Vanderstraeten G. A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs dexamethasone injection in rotator cuff syndrome: the TRAumeel in ROtator cuff syndrome (TRARO) study protocol. BMC Musculoskelet Disord. 2015;16:1. https://doi.org/10.1186/S12891-015-0471-Z.
Schneider C. Traumeel - an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuriesInt J Gen Med. 2011; 25(4):225–34. https://doi.org/10.2147/IJGM.S16709.
Porozov S, Cahalon L, Weiser M, Branski D, Lider O, Oberbaum M. Inhibition of IL-1beta and TNF-alpha secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S. Clin Dev Immunol. 2004;11(2):143–9. https://doi.org/10.1080/10446670410001722203.
Lussignoli S, Bertani S, Metelmann H, Bellavite P, Conforti A. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complement Ther Med. 1999;7(4):225–30. https://doi.org/10.1016/S0965-2299(99)80006-5.
Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med. 2008;16(1):22–7. https://doi.org/10.1016/J.CTIM.2007.04.004.
Sanchez C, et al. Reduction of matrix metallopeptidase 13 and promotion of chondrogenesis by Zeel T in primary human osteoarthritic chondrocytes. Front Pharmacol. 2021;12 https://doi.org/10.3389/FPHAR.2021.635034/FULL.
Lee P, Rattenberry A, Connelly S, Nokes L. Our experience on Actovegin, is it cutting edge? Int J Sports Med. 2011;32(4):237–41. https://doi.org/10.1055/S-0030-1269862.
Søndergård SD, Dela F, Helge JW, Larsen S. Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci. 2016;16(7):801–7. https://doi.org/10.1080/17461391.2015.1130750.
Lee P, Kwan A, Nokes L. Actovegin—cutting-edge sports medicine or ‘voodoo’ remedy? Curr Sports Med Rep. 2011;10(4):186–90. https://doi.org/10.1249/JSR.0B013E318223CD8A.
Buchmayer F, Pleiner J, Elmlinger MW, Lauer G, Nell G, Sitte HH. Actovegin®: a biological drug for more than 5 decades. Wien Med Wochenschr. 2011;161(3–4):80–8. https://doi.org/10.1007/S10354-011-0865-Y.
Elmlinger MW, Kriebel M, Ziegler D. Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro. doi: https://doi.org/10.1007/s12017-011-8157-7.
Lee P, Nokes L, Smith PM. No effect of intravenous Actovegin® on peak aerobic capacity. Int J Sports Med. 2012;33(4):305–9. https://doi.org/10.1055/S-0031-1291322.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bayram, B., Kocaoglu, B. (2024). Deproteinized Hemoderivative of Calf Blood-Natural Botanical and Mineral Extracts. In: Kocaoglu, B., Laver, L., Girolamo, L.d., Compagnoni, R. (eds) Musculoskeletal Injections Manual. Springer, Cham. https://doi.org/10.1007/978-3-031-52603-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-031-52603-9_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-52602-2
Online ISBN: 978-3-031-52603-9
eBook Packages: MedicineMedicine (R0)