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Funktionalisierung von Heteroarenen unter kontinuierlichem Durchfluss

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Flow-Chemie für die Synthese von Heterocyclen

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Zusammenfassung

Aromatische Heterocyclen sind allgegenwärtige Motive in pharmazeutischen und agrochemischen Strukturen. Die Funktionalisierung dieser Ringsysteme ist ein wichtiger Teil vieler synthetischer Verfahren. In diesem Kapitel wird ein Überblick darüber gegeben, wie die Mikrodurchflusstechnologie als leistungsstarkes Werkzeug für die Diversifizierung von Heteroarenen eingesetzt wurde. Ein Schwerpunkt liegt auf der Feinchemiesynthese, obwohl auch Reaktordesign und Problemlösung diskutiert werden, wenn sie relevant sind, da sie einen wichtigen Teil des Forschungsfeldes ausmachen. Pragmatische Übersetzungen in den Mikrodurchfluss werden für bestehende Funktionalisierungsprotokolle überprüft, und einige schwer fassbare Reaktionen werden hervorgehoben, die im Batch-Modus nicht zufriedenstellend durchgeführt werden können.

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Authors and Affiliations

  1. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium

    Joachim Demaerel, Vidmantas Bieliūnas & Wim M. De Borggraeve

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  1. Joachim Demaerel
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  2. Vidmantas Bieliūnas
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  3. Wim M. De Borggraeve
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Correspondence to Wim M. De Borggraeve .

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  1. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Upendra K. Sharma

  2. Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium

    Erik V. Van der Eycken

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Demaerel, J., Bieliūnas, V., De Borggraeve, W.M. (2024). Funktionalisierung von Heteroarenen unter kontinuierlichem Durchfluss. In: Sharma, U.K., Van der Eycken, E.V. (eds) Flow-Chemie für die Synthese von Heterocyclen. Springer Spektrum, Cham. https://doi.org/10.1007/978-3-031-51912-3_6

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