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References

  1. Soga J, Osaka M, Yakuwa Y. Carcinoids of the ovary: an analysis of 329 reported cases. J Exp Clin Cancer Res. 2000;19(3):271–80.

    CAS  PubMed  Google Scholar 

  2. Chatzipantelis P, Mavrogiorgis A, Kairi-Vassilatou E, Pafiti A. Ovarian neoplasm composed of an insular carcinoid tumor and a borderline mucinous cystadenoma arising in a mature cystic teratoma: a case report. Eur J Gynaecol Oncol. 2006;27(6):636–7.

    CAS  PubMed  Google Scholar 

  3. Niu D, Li Z, Sun L, Cao D. Carcinoid arising from the teratomatous bronchial mucosa in a mature cystic teratoma of the ovary: a case report. Int J Gynecol Pathol. 2018;37(2):123–7.

    Article  PubMed  Google Scholar 

  4. Rabban JT, Zaloudek CJ. A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord-stromal tumours. Histopathology. 2013;62(1):71–88.

    Article  PubMed  Google Scholar 

  5. Zhang X, Jones A, Jenkins SM, Huang Y. Ki67 proliferative index in carcinoid tumors involving ovary. Endocr Pathol. 2018;29(1):43–8.

    Article  CAS  PubMed  Google Scholar 

  6. Baker PM, Oliva E, Young RH, Talerman A, Scully RE. Ovarian mucinous carcinoids including some with a carcinomatous component: a report of 17 cases. Am J Surg Pathol. 2001;25(5):557–68.

    Article  CAS  PubMed  Google Scholar 

  7. Opalińska M, Sowa-Staszczak A, Olearska H, Ulatowska-Bialas M, Gilis-Januszewska A, Hubalewska-Dydejczyk A. Clinical approach to neuroendocrine neoplasm associated with ovarian teratoma. Front Endocrinol (Lausanne). 2021;12:770266.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Huang B, Wu X, Zhou Q, Hu Y, Zhao H, Zhu H, et al. Cushing’s syndrome secondary to ectopic ACTH secretion from carcinoid tumor within an ovarian mature teratoma: a case report and review of the literature. Gynecol Endocrinol. 2014;30(3):192–6.

    Article  PubMed  Google Scholar 

  9. Robboy SJ, Norris HJ, Scully RE. Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer. 1975;36(2):404–18.

    Article  CAS  PubMed  Google Scholar 

  10. Safdar NS, Stall JN, Young RH. Malignant mixed germ cell tumors of the ovary: an analysis of 100 cases emphasizing the frequency and interrelationships of their tumor types. Am J Surg Pathol. 2021;45(6):727–41.

    Article  PubMed  Google Scholar 

  11. Cao D, Guo S, Allan RW, Molberg KH, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009;33(6):894–904.

    Article  PubMed  Google Scholar 

  12. Nakashima N, Murakami S, Fukatsu T, Nagasaka T, Fukata S, Ohiwa N, et al. Characteristics of “embryoid body” in human gonadal germ cell tumors. Hum Pathol. 1988;19(10):1144–54.

    Article  CAS  PubMed  Google Scholar 

  13. WHO Classification of Tumours Editorial Board. Female genital tumours. Lyon (France): International Agency for Research on Cancer; 2020. (WHO Classification of tumours series, 5th ed.; vol4). https://publications.iarc.fr/592.

  14. Young RH, Ulbright TM, Policarpio-Nicolas ML. Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases. Am J Surg Pathol. 2013;37(3):393–8.

    Article  PubMed  Google Scholar 

  15. Jondle DM, Shahin MS, Sorosky J, Benda JA. Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. Int J Gynecol Pathol. 2002;21(1):78–81.

    Article  PubMed  Google Scholar 

  16. Szyfelbein WM, Young RH, Scully RE. Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. Am J Surg Pathol. 1995;19(1):21–9.

    Article  CAS  PubMed  Google Scholar 

  17. Szyfelbein WM, Young RH, Scully RE. Cystic struma ovarii: a frequently unrecognized tumor. A report of 20 cases. Am J Surg Pathol. 1994;18(8):785–8.

    Article  CAS  PubMed  Google Scholar 

  18. Devaney K, Snyder R, Norris HJ, Tavassoli FA. Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol. 1993;12(4):333–43.

    Article  CAS  PubMed  Google Scholar 

  19. Wei S, Baloch ZW, LiVolsi VA. Pathology of struma ovarii: a report of 96 cases. Endocr Pathol. 2015;26(4):342–8.

    Article  PubMed  Google Scholar 

  20. Castillo Simón AG, Martínez Ramos CV, Rodríguez Morales VV, Núñez Arana B, Dominguez Prado I, Muñoz Iglesias JL. Follicular thyroid carcinoma arising in a struma ovarii and femoral metastasis. Rev Esp Med Nucl Imagen Mol (Engl Ed). 2022;41(5):325–6.

    PubMed  Google Scholar 

  21. Barrera JR, Manalo LA, Ang FL. Papillary thyroid-type carcinoma arising from struma ovarii. BMJ Case Rep. 2012;2012.

    Google Scholar 

  22. Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA. Malignant struma ovarii: a population-level analysis of a large series of 68 patients. Thyroid. 2015;25(2):211–5.

    Article  PubMed  Google Scholar 

  23. Roth LM, Karseladze AI. Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol. 2008;27(2):213–22.

    PubMed  Google Scholar 

  24. Fukunaga M, Ishibashi T, Koyama T, Onoue K, Kitai S, Tanaka K, et al. Malignant struma ovarii with a predominant component of anaplastic carcinoma. Int J Gynecol Pathol. 2016;35(4):357–61.

    Article  PubMed  Google Scholar 

  25. Tsukada T, Yoshida H, Ishikawa M, Asami Y, Shiraishi K, Kato T. Malignant struma ovarii presenting with follicular carcinoma: a case report with molecular analysis. Gynecol Oncol Rep. 2019;30:100498.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Tan A, Stewart CJ, Garrett KL, Rye M, Cohen PA. Novel BRAF and KRAS mutations in papillary thyroid carcinoma arising in struma ovarii. Endocr Pathol. 2015;26(4):296–301.

    Article  PubMed  Google Scholar 

  27. Roth LM, Talerman A. The enigma of struma ovarii. Pathology. 2007;39(1):139–46.

    Article  PubMed  Google Scholar 

  28. Podfigurna A, Szeliga A, Horwat P, Maciejewska-Jeske M, Meczekalski B. Hyperthyroidism associated with struma ovarii—a case report and review of literature. Gynecol Endocrinol. 2021;37(12):1143–50.

    Article  PubMed  Google Scholar 

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Saglam, O. (2023). Germ Cell Tumors. In: Challenging Cases in Gynecologic Surgical Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-51656-6_4

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  • DOI: https://doi.org/10.1007/978-3-031-51656-6_4

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