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Polychlorinated Biphenyls (PCBs)

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Pollutants of Global Concern

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Abstract

Polychlorinated biphenyls, or PCBs, are a broad category of organic chemicals used in a variety of industrial and commercial processes. Despite being used in industrial settings, PCBs have never been manufactured in India. India, being a signatory, is required to comply with the Stockholm Convention’s requirements to phase out PCB use in equipment by 2025 and eliminate PCBs entirely by 2028. Since 1966, PCBs have been found in environmental matrices, and depositions of industrial applications, incinerators, and biomass combustions are some of the ways they are exposed in soil. Thirteen of the 209 different PCB types show toxicity similar to that of dioxin. PCBs have been classified as probable human carcinogen by the International Agency for Research on Cancer as well as by Environment protection Agency and listed by the Stockholm Convention as persistent organic pollutants (POPs) under Dirty Dozens. Exposure assessment studies have been carried out in humans as a function of health, along with studies on particular matrices like the atmosphere, soil, water, and organisms, but there is still a need for additional research to determine how these matrices can more accurately reflect on humans.

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References

  • Akash, M. S. H., Rehman, K., & Hashmi, M. Z. (Eds.). (2021). Endocrine disrupting chemicals-induced metabolic disorders and treatment strategies. Springer.

    Google Scholar 

  • Amoyaw-Osei, Y., Agyekum, O., Mueller, E., Fasko, R., Schluep, M. (2011). Ghana E-Waste country assessment. Secretariat of the Basel Convention. Accessed at www.ewasteguide.info/Amoyaw-Osei_2011_GreenAd-Empa. Date Accessed 20th July, 2016

  • Andeobu, L., Wibowo, S., & Grandhi, S. (2021). A systematic review of e-waste generation and environmental management of Asia Pacific countries. International Journal of Environmental Research and Public Health, 18(17), 9051.

    Article  Google Scholar 

  • ATSDR, A. (2000). Toxicological profile for polychlorinated biphenyls (PCBs). Agency for Toxic Substances and Disease Registry.

    Google Scholar 

  • Bandow, N., Conrad, A., Kolossa-Gehring, M., Murawski, A., & Sawal, G. (2020). Polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP) in blood plasma–Results of the German environmental survey for children and adolescents 2014–2017 (GerES V). International Journal of Hygiene and Environmental Health, 224, 113426.

    Google Scholar 

  • Bedard, D. L. (2008). A case study for microbial biodegradation: Anaerobic bacterial reductive dechlorination of polychlorinated biphenyls—From sediment to defined medium. Annual Review of Microbiology, 62, 253–270.

    Article  CAS  Google Scholar 

  • Bedard, D. L., Van Dort, H. M., May, R. J., & Smullen, L. A. (1997). Enrichment of microorganisms that sequentially meta, para-dechlorin-ate the residue of aroclor 1260 in Housatonic River sediment. Environmental Science & Technology, 31(11), 3308–3313.

    Article  CAS  Google Scholar 

  • Berkaw, M., Sowers, K. R., & May, H. D. (1996). Anaerobic ortho dechlorination of polychlorinated biphenyls by estuarine sediments from Baltimore Harbor. Applied and Environmental Microbiology, 62(7), 2534–2539.

    Article  CAS  Google Scholar 

  • Bloom, M. S., Fujimoto, V. Y., Storm, R., Zhang, L., Butts, C. D., Sollohub, D., & Jansing, R. L. (2017). Persistent organic pollutants (POPs) in human follicular fluid and in vitro fertilization outcomes, a pilot study. Reproductive Toxicology, 67, 165–173.

    Article  CAS  Google Scholar 

  • Boyle, A. W., Silvin, C. J., Hassett, J. P., Nakas, J. P., & Tanenbaum, S. W. (1992). Bacterial PCB biodegradation. Biodegradation, 3, 285–298.

    Article  CAS  Google Scholar 

  • Breivik, K., Sweetman, A., Pacyna, J. M., & Jones, K. C. (2002). Towards a global historical emission inventory for selected PCB congeners—A mass balance approach: 2. Emissions. Science of the Total Environment, 290(1–3), 199–224.

    Article  CAS  Google Scholar 

  • Brucker-Davis, F., Ganier-Chauliac, F., Gal, J., Panaïa-Ferrari, P., Pacini, P., Fénichel, P., & Hiéronimus, S. (2015). Neurotoxicant exposure during pregnancy is a confounder for assessment of iodine supplementation on neurodevelopment outcome. Neurotoxicology and Teratology, 51, 45–51.

    Article  CAS  Google Scholar 

  • Carlson, L. M., Christensen, K., Sagiv, S. K., Rajan, P., Klocke, C. R., Lein, P. J., et al. (2022). A systematic evidence map for the evaluation of noncancer health effects and exposures to polychlorinated biphenyl mixtures. Environmental Research, 202, 115148.

    Google Scholar 

  • Chakraborty, P., Selvaraj, S., Nakamura, M., Prithiviraj, B., Cincinelli, A., & Bang, J. J. (2018). PCBs and PCDD/Fs in soil from informal e-waste recycling sites and open dumpsites in India: Levels, congener profiles and health risk assessment. Science of the Total Environment, 621, 930–938, ISSN 0048-9697,. https://doi.org/10.1016/j.scitotenv.2017.11.083

    Article  CAS  Google Scholar 

  • Chang, C. J., Terrell, M. L., Marcus, M., Marder, M. E., Panuwet, P., Ryan, P. B., ... & Barr, D. B. (2020). Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident. Environment International, 137, 105526.

    Google Scholar 

  • Devi, N., Yadav, I., Qi, S., Chakraborty, P., & Dan, Y. (2014). Distribution and risk assessment of polychlorinated biphenyls (PCBs) in the remote air and soil of Manipur, India. Environmental Geology, 72, 3955. https://doi.org/10.1007/s12665-014-3284-8

    Article  CAS  Google Scholar 

  • Dolgova, S. V., & Denisenko, A. N. (2010). Cancer morbidity in the Nizhny Novgorod region. Oncology service state of art and the ways for its improvement. Meditsinskiy al’manakh, 3, 42–45.

    Google Scholar 

  • Du, S., Rodenburg, L., Patterson, N., Chu, C., Riker, C. D., Yu, C. H., & Fan, Z. T. (2020). Concentration of polychlorinated biphenyls in serum from New Jersey biomonitoring study: 2016–2018. Chemosphere, 261, 127730.

    Google Scholar 

  • Emmett, E. A. (1985). Polychlorinated biphenyl exposure and effects in transformer repair workers. Environmental Health Perspectives, 60, 185–192.

    Article  CAS  Google Scholar 

  • Emmett, E. A., Maroni, M., Jefferys, J., Schmith, J., Levin, B. K., & Alvares, A. (1988). Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. American Journal of Industrial Medicine, 14(1), 47–62.

    Article  CAS  Google Scholar 

  • Furukawa, K. (2000). Biochemical and genetic bases of microbial degradation of polychlorinated biphenyls (PCBs). The Journal of General and Applied Microbiology, 46(6), 283–296.

    Article  CAS  Google Scholar 

  • Girones, L., Oliva, A. L., Negrin, V. L., Marcovecchio, J. E., & Arias, A. H. (2021). Persistent organic pollutants (POPs) in coastal wetlands: A review of their occurrences, toxic effects, and biogeochemical cycling. Marine Pollution Bulletin, 172, 112864.

    Article  CAS  Google Scholar 

  • Gomes, H. I., Dias-Ferreira, C., & Ribeiro, A. B. (2013). Overview of in situ and ex situ remediation technologies for PCB-contaminated soils and sediments and obstacles for full-scale application. Science of the Total Environment, 445, 237–260.

    Article  Google Scholar 

  • Grindler, N. M., Allsworth, J. E., Macones, G. A., Kannan, K., Roehl, K. A., & Cooper, A. R. (2015). Persistent organic pollutants and early menopause in US women. PLoS One, 10(1), e0116057.

    Article  Google Scholar 

  • Guo, Y. L., Lambert, G. H., & Hsu, C. C. (1995). Growth abnormalities in the population exposed in utero and early postnatally to polychlorinated biphenyls and dibenzofurans. Environmental Health Perspectives, 103(suppl 6), 117–122.

    Article  CAS  Google Scholar 

  • Hess, W. R., Rocap, G., Ting, C. S., Larimer, F., Stilwagen, S., Lamerdin, J., & Chisholm, S. W. (2001). The photosynthetic apparatus of Prochlorococcus: Insights through comparative genomics. Photosynthesis Research, 70, 53–71.

    Article  CAS  Google Scholar 

  • Hofvander, L. (2006). Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification. Doctoral dissertation, Institutionen för miljökemi.

    Google Scholar 

  • Huang, W., He, Y., Xiao, J., Huang, Y., Li, A., He, M., & Wu, K. (2019). Risk of breast cancer and adipose tissue concentrations of polychlorinated biphenyls and organochlorine pesticides: A hospital-based case-control study in Chinese women. Environmental Science and Pollution Research, 26, 32128–32136.

    Article  CAS  Google Scholar 

  • Ishankulov, M. (2008). PCB-contaminated areas in Kazakhstan and analysis of PCB impact on human health experience. In The fate of persistent organic pollutants in the environment (pp. 387–403). Springer.

    Chapter  Google Scholar 

  • Kalloo, G., Wellenius, G. A., McCandless, L., Calafat, A. M., Sjodin, A., Romano, M. E., et al. (2020). Exposures to chemical mixtures during pregnancy and neonatal outcomes: The HOME study. Environment International, 134, 105219.

    Article  CAS  Google Scholar 

  • Kalloo, G., Wellenius, G. A., McCandless, L., Calafat, A. M., Sjodin, A., Sullivan, A. J., et al. (2021). Chemical mixture exposures during pregnancy and cognitive abilities in school-aged children. Environmental Research, 197, 111027.

    Article  CAS  Google Scholar 

  • Khalid, F., Hashmi, M. Z., Jamil, N., Qadir, A., & Ali, M. I. (2021). Microbial and enzymatic degradation of PCBs from e-waste-contaminated sites: A review. Environmental Science and Pollution Research, 28, 10474–10487.

    Article  CAS  Google Scholar 

  • Kim, A. W., Vane, C. H., Moss-Hayes, V., Engelhart, S. E., & Kemp, A. C. (2018). PAH, PCB, TPH and mercury in surface sediments of the Delaware River Estuary and Delmarva Peninsula, USA. Marine Pollution Bulletin, 129(2), 835–845.

    Article  CAS  Google Scholar 

  • Klocke, C., Sethi, S., & Lein, P. J. (2020). The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): Similarities and differences. Environmental Science and Pollution Research, 27, 8885–8896.

    Article  CAS  Google Scholar 

  • Kumar, B., Singh, S. K., Mishra, M., Kumar, S., & Sharma, C. S. (2012). Assessment of polychlorinated biphenyls and organochlorine pesticides in water samples from the Yamuna River. Journal of Xenobiotics, 2(1), e6.

    Article  Google Scholar 

  • Kumar, B., Kumar, S., & Sharma, C. S. (2013). Ecotoxicological risk assessment of polychlorinated biphenyls (PCBs) in bank sediments from along the Yamuna River in Delhi, India. Human and Ecological Risk Assessment: An International Journal, 19(6), 1477–1487.

    Article  CAS  Google Scholar 

  • Kumar, K. K., Devi, B. U., & Neeraja, P. (2018). Elucidation of endocrine—Disrupting polychlorinated biphenyls binding potency with steroidogenic genes: Integration of in silico methods and ensemble docking approaches. Ecotoxicology and Environmental Safety, 165, 194–201.

    Article  Google Scholar 

  • Kumari, K. (Ed.). (2021). Persistent organic pollutants: Gaps in management and associated challenges (1st ed.). CRC Press. https://doi.org/10.1201/9781003046806

    Book  Google Scholar 

  • Lauby-Secretan, B., Loomis, D., Baan, R., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., et al. (2016). Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds. Environmental Science and Pollution Research, 23, 2220–2229.

    Article  CAS  Google Scholar 

  • Lawton, R. W., Ross, M. R., Feingold, J., & Brown, J. F., Jr. (1985). Effects of PCB exposure on biochemical and hematological findings in capacitor workers. Environmental Health Perspectives, 60, 165–184.

    Article  CAS  Google Scholar 

  • Liu, S., Li, S., & Du, Y. (2010). Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK). PLoS One, 5(6), e11272.

    Article  Google Scholar 

  • Montano, L., Pironti, C., Pinto, G., Ricciardi, M., Buono, A., Brogna, C., et al. (2022). Polychlorinated biphenyls (PCBs) in the environment: Occupational and exposure events, effects on human health and fertility. Toxics, 10(7), 365.

    Article  CAS  Google Scholar 

  • Neblett, M. F., Curtis, S. W., Gerkowicz, S. A., Spencer, J. B., Terrell, M. L., Jiang, V. S., et al. (2020). Examining reproductive health outcomes in females exposed to polychlorinated biphenyl and polybrominated biphenyl. Scientific Reports, 10(1), 3314.

    Article  CAS  Google Scholar 

  • Needham, T. P., & Ghosh, U. (2019). Four decades since the ban, old urban wastewater treatment plant remains a dominant source of PCBs to the environment. Environmental Pollution, 246, 390–397.

    Article  CAS  Google Scholar 

  • Nayak, Y., Sahu, Y. K., Patel, K. S., Sharma, S., Hung, C. C., Martín-Ramos, P., & Yurdakul, S. (2021). Distribution and sources of polychlorinated biphenyls in air, dust, and sediment from India. Journal of Hazardous, Toxic, and Radioactive Waste, 25(1), 05020004.

    Google Scholar 

  • Orlinskii, D., Priputina, I., Popova, A., Shalanda, A., Tsongas, T., Hinman, G., & Butcher, W. (2001). Influence of environmental contamination with PCBs on human health. Environmental Geochemistry and Health, 23, 313–328.

    Article  Google Scholar 

  • Parmar, J., & Qureshi, A. (2023). Accounting of the use and emissions of polychlorinated biphenyl compounds (PCBs) in India, 1951–2100. Environmental Science & Technology, 57(12), 4763–4774.

    Article  CAS  Google Scholar 

  • Patel, K. S., Ramteke, S., Sahu, B. L., Nayak, Y., Sharma, S., & Hung, C. C. (2015). Polychlorinated biphenyls contamination of sludge in India. American Journal of Analytical Chemistry, 6(11), 867.

    Article  CAS  Google Scholar 

  • Polachova, A., Gramblicka, T., Bechynska, K., Parizek, O., Parizkova, D., Dvorakova, D., ... & Pulkrabova, J. (2021). Biomonitoring of 89 POPs in blood serum samples of Czech city policemen. Environmental Pollution, 291, 118140.

    Google Scholar 

  • Portigal, C. L., Cowell, S. P., Fedoruk, M. N., Butler, C. M., Rennie, P. S., & Nelson, C. C. (2002). Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicology and Applied Pharmacology, 179(3), 185–194.

    Article  CAS  Google Scholar 

  • Quensen, J. F., III, Boyd, S. A., & Tiedje, J. M. (1990). Dechlorination of four commercial polychlorinated biphenyl mixtures (Aroclors) by anaerobic microorganisms from sediments. Applied and Environmental Microbiology, 56(8), 2360–2369.

    Article  CAS  Google Scholar 

  • Reddy, A. V. B., Moniruzzaman, M., & Aminabhavi, T. M. (2019). Polychlorinated biphenyls (PCBs) in the environment: Recent updates on sampling, pretreatment, cleanup technologies and their analysis. Chemical Engineering Journal, 358, 1186-1207. ISSN 1385–8947.

    Google Scholar 

  • Ripley, K. (2017). The 2017 BRS COPs: Steps Forward, But Challenges Persist. Environmental Policy and Law, 47, 66.

    Google Scholar 

  • Robertson, L. W., & Ludewig, G. (2011). Polychlorinated biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrstoffe, Reinhaltung der Luft= Air quality control/Herausgeber, BIA und KRdL im VDI und DIN, 71(1-2), 25.

    CAS  Google Scholar 

  • Safe, S. (1993). Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: Progress and problems. Environmental Health Perspectives, 100, 259–268.

    Article  CAS  Google Scholar 

  • Safe, S. H. (2007). Environmental and occupational medicine. In W. N. Rom (Ed.), Chapter 77: Polychlorinated biphenyls (4th ed.). Lippincott Williams & Wilkins.

    Google Scholar 

  • Saktrakulkla, P., Lan, T., Hua, J., Marek, R. F., Thorne, P. S., & Hornbuckle, K. C. (2020). Polychlorinated biphenyls in food. Environmental Science & Technology, 54(18), 11443–11452.

    Article  CAS  Google Scholar 

  • Schettgen, T., Alt, A., Schikowsky, C., Esser, A., & Kraus, T. (2018). Human biomonitoring of polychlorinated biphenyls (PCBs) in plasma of former underground miners in Germany–A case-control study. International Journal of Hygiene and Environmental Health, 221(7), 1007–1011.

    Google Scholar 

  • Swackhamer, D. L., & Armstrong, D. E. (1986). Estimation of the atmospheric and nonatmospheric contributions and losses of polychlorinated biphenyls to Lake Michigan on the basis of sediment records of remote lakes. Environmental Science & Technology, 20(9), 879–883.

    Article  CAS  Google Scholar 

  • Toft, G. (2014). Persistent organochlorine pollutants and human reproductive health. Danish Medical Journal, 61(11), B4967.

    Google Scholar 

  • Toft, G., Thulstrup, A. M., Jönsson, B. A., Pedersen, H. S., Ludwicki, J. K., Zvezday, V., & Bonde, J. P. (2010). Fetal loss and maternal serum levels of 2, 2′, 4, 4′, 5, 5′-hexachlorbiphenyl (CB-153) and 1, 1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p, p′-DDE) exposure: A cohort study in Greenland and two European populations. Environmental Health, 9, 1–11.

    Article  Google Scholar 

  • Uwimana, E., Cagle, B., Yeung, C., Li, X., Patterson, E. V., Doorn, J. A., & Lehmler, H. J. (2019). Atropselective oxidation of 2, 2′, 3, 3′, 4, 6′-hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for PCB 132 neurotoxicity. Toxicological Sciences, 171(2), 406–420.

    Article  CAS  Google Scholar 

  • Valle Dalla, M., Marcomini, A., Jones, K. C., & Sweetman, A. J. (2005). Reconstruction of historical trends of PCDD/Fs and PCBs in the Venice Lagoon, Italy. Environment International, 31(7), 1047–1052.

    Article  Google Scholar 

  • Van Gerven, T., Geysen, D., & Vandecasteele, C. (2004). Estimation of the contribution of a municipal waste incinerator to the overall emission and human intake of PCBs in Wilrijk, Flanders. Chemosphere, 54(9), 1303–1308.

    Article  Google Scholar 

  • Whitehead, A., Triant, D. A., Champlin, D., & Nacci, D. (2010). Comparative transcriptomics implicates mechanisms of evolved pollution tolerance in a killifish population. Molecular Ecology, 19(23), 5186–5203.

    Article  CAS  Google Scholar 

  • Wild, S. R., & Jones, K. C. (1995). Polynuclear aromatic hydrocarbons in the United Kingdom environment: A preliminary source inventory and budget. Environmental Pollution, 88(1), 91–108.

    Article  CAS  Google Scholar 

  • You, H., Ding, J., Zhao, X. S., Li, Y. F., Liu, L. Y., Ma, W. L., et al. (2011). Spatial and seasonal variation of polychlorinated biphenyls in Songhua River, China. Environmental Geochemistry and Health, 33, 291–299.

    Article  CAS  Google Scholar 

  • Zanaroli, G., Negroni, A., Häggblom, M. M., & Fava, F. (2015). Microbial dehalogenation of organohalides in marine and estuarine environments. Current Opinion in Biotechnology, 33, 287–295.

    Article  CAS  Google Scholar 

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  1. CSIR-National Environmental Engineering Research Institute (NEERI), Kolkata Zonal Center, Kolkata, West Bengal, India

    Kanchan Kumari

  2. CSIR-National Environmental Engineering Research Institute (NEERI), Nagpur, India

    Senerita Swamy

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  1. Kanchan Kumari
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  2. Senerita Swamy
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Correspondence to Kanchan Kumari .

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Kumari, K., Swamy, S. (2024). Polychlorinated Biphenyls (PCBs). In: Pollutants of Global Concern. Emerging Contaminants and Associated Treatment Technologies. Springer, Cham. https://doi.org/10.1007/978-3-031-50996-4_10

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