Abstract
Aluminum oxide nanoparticles (Al2O3 NPs) have attracted significant attention to various scientific and industrial fields due to their unique bio−/physicochemical properties: high surface area, high hardness, thermal stability, biocompatibility, surface functionalization, and electrical insulation. This chapter exposes the key aspects of Al2O3 NPs synthesis that include sol-gel, hydrothermal, combustion, and green methods. Each method provides control over the particle size, shape, and chemical surface, enabling tailored nanoparticles for specific applications. In catalysis, Al2O3 NPs serve as efficient catalyst supports, enhancing reaction rates and selectivity. Additionally, their remarkable dielectric properties make them valuable for electronic and optoelectronic devices. Moreover, Al2O3 NPs have demonstrated promising results in biomedical applications, including drug delivery systems, biomedical imaging, biosensing, and tissue engineering. Furthermore, recent studies have shown that Al2O3 NPs have potent antimicrobial and antiviral properties. Due to their small size, they can penetrate bacterial and viral cells more effectively, increasing the efficacy of their action. Al2O3 NPs can be incorporated into coatings for medical devices and hospital surfaces, helping prevent bacterial adhesion and biofilm formation, thereby reducing the risk of infections. In addition, Al2O3 NPs have demonstrated potent adjuvant activity for several vaccines throughout history, targeting and neutralizing a wide range of microorganisms. In the future, Al2O3 NPs hold great promise as key components in a wide range of advanced materials and applications, like advanced coatings, energy storage systems, catalysis, biomedical applications, environmental remediation, optoelectronics, photonics, and personal care products.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmad, F., Salem-Bekhit, M. M., Khan, F., Alshehri, S., Khan, A., Ghoneim, M. M., et al. (2022). Unique properties of surface-functionalized nanoparticles for bio-application: Functionalization mechanisms and importance in application. Nanomaterials, 12(8). https://doi.org/10.3390/nano12081333
Allan, J., Belz, S., Hoeveler, A., Hugas, M., Okuda, H., Patri, A., et al. (2021). Regulatory landscape of nanotechnology and nanoplastics from a global perspective. Regulatory Toxicology and Pharmacology, 122, 104885. https://doi.org/10.1016/J.YRTPH.2021.104885
Altammar, K. A. (2023). A review on nanoparticles: Characteristics, synthesis, applications, and challenges. Frontiers in Microbiology, 14(April), 1–20. https://doi.org/10.3389/fmicb.2023.1155622
Aramesh, M., Tran, P. A., Ostrikov, K., & (Ken), & Prawer, S. (2017). Conformal nanocarbon coating of alumina nanocrystals for biosensing and bioimaging. Carbon, 122, 422–427. https://doi.org/10.1016/J.CARBON.2017.06.101
Athari, S. S., Pourpak, Z., Folkerts, G., Garssen, J., Moin, M., Adcock, I. M., et al. (2016). Conjugated alpha-alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice. European Journal of Pharmacology, 791, 811–820. https://doi.org/10.1016/J.EJPHAR.2016.10.014
Baek, Y., Lim, S., Ho, L., Park, S., Woo, S., Hwan, T., et al. (2016). Al2 O3/TiO2 nanolaminate gate dielectric fi lms with enhanced electrical performances for organic fi eld-effect transistors. Organic Electronics, 28, 139–146. https://doi.org/10.1016/j.orgel.2015.10.025
Balasubramanyam, A., Sailaja, N., Mahboob, M., Rahman, M. F., Hussain, S. M., & Grover, P. (2010). Toxicology in vitro in vitro mutagenicity assessment of aluminium oxide nanomaterials using the Salmonella/microsome assay. Toxicology In Vitro, 24(6), 1871–1876. https://doi.org/10.1016/j.tiv.2010.07.004
Beaton, G., Zacks, J., & Stamplecoskie, K. (2022). Al2O3 anchored silver and gold nanoparticles as accessible, stable, and re-usable catalysts. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 646, 128972. https://doi.org/10.1016/J.COLSURFA.2022.128972
Beyzay, F., Hosseini, A. Z., & Soudi, S. (2017). Alpha alumina nanoparticle conjugation to cysteine peptidase a and B: An efficient method for autophagy induction. Avicenna Journal of Medical Biotechnology, 9(2), 71. Retrieved from /pmc/articles/PMC5410132/.
Bianchi, E., Vigani, B., Viseras, C., Ferrari, F., Rossi, S., & Sandri, G. (2022). Inorganic nanomaterials in tissue engineering. Pharmaceutics, 14(6). https://doi.org/10.3390/pharmaceutics14061127
Bokov, D., Jalil, A. T., Chupradit, S., Suksatan, W., Ansari, M. J., Shewael, I. H., et al. (2021). Nanomaterial by sol-gel method: synthesis and application. Adv Mater Sci Eng, 2021, 5102014.
Chapurina, Y. E., Drozdov, A. S., Popov, I., Vinogradov, V. V., Dudanov, I. P., & Vinogradov, V. V. (2016). Streptokinase@alumina nanoparticles as a promising thrombolytic colloid with prolonged action. Journal of Materials Chemistry B, 4(35), 5921–5928. https://doi.org/10.1039/C6TB01349J
Chavali, M. S., Nikolova, M. P., & Silver, A. (2019). Metal oxide nanoparticles and their applications in nanotechnology. SN Applied Sciences, 1(6), 1–30. https://doi.org/10.1007/s42452-019-0592-3
Chen, K. L., & Bothun, G. D. (2014). Nanoparticles meet cell membranes: Probing nonspecific interactions using model membranes. Environmental Science and Technology, 48(2), 873–880. https://doi.org/10.1021/es403864v
Chidhambaram, N. (2019). Augmented antibacterial efficacies of the aluminium doped ZnO nanoparticles against four pathogenic bacteria. Materials Research Express, 6(7). https://doi.org/10.1088/2053-1591/AB1804
Daroughegi, R., Meshkani, F., & Rezaei, M. (2019). Characterization and evaluation of mesoporous high surface area promoted Ni- Al2O3 catalysts in CO2 methanation. Journal of the Energy Institute. https://doi.org/10.1016/j.joei.2019.07.003
Derakhshankhah, H., Jafari, S., Sarvari, S., Barzegari, E., Moakedi, F., Ghorbani, M., et al. (2020). Biomedical applications of Zeolitic nanoparticles, with an emphasis on medical interventions (Vol. 15, p. 363). https://doi.org/10.2147/IJN.S234573
Design and Fabrication of Ordered Mesoporous Alumina Scaffold for Drug Delivery of Poorly Water Soluble Drug. (2023). https://austinpublishinggroup.com/therapeutics/fulltext/therapeutics-v2-id1015.php
Egbuna, C., Parmar, V. K., Jeevanandam, J., Ezzat, S. M., Patrick-Iwuanyanwu, K. C., Adetunji, C. O., et al. (2021). Toxicity of nanoparticles in biomedical application: Nanotoxicology. Journal of Toxicology, 2021, 1. https://doi.org/10.1155/2021/9954443
Fawcett, D. (2011). Significance of novel bioinorganic anodic aluminum oxide nanoscaffolds for promoting cellular response (Vol. 4, p. 11). https://doi.org/10.2147/NSA.S13913
Förster, G. D. (2020). Influence of oxidizing conditions on the condensation of aluminum oxide nanoparticles: Insights from atomistic modeling. Applied Surface Science, 512, 145440.
Gholizadeh, Z., Aliannezhadi, M., Ghominejad, M., & Tehrani, F. S. (2023). High specific surface area γ-Al2O3 nanoparticles synthesized by facile and low-cost co-precipitation method. Scientific Reports, 13(1), 1–14. https://doi.org/10.1038/s41598-023-33266-0
Girimurugan, K., Arunraja, M., Shanmugam, A., & Saranya, S. M. V. (2023). The effects of nano-alumina particles on the enrichment of tensile, flexural and impact properties of carbon fiber-reinforced epoxy composites. Materials Today: Proceedings. https://doi.org/10.1016/j.matpr.2023.04.053
Gudkov, S. V., Burmistrov, D. E., Smirnova, V. V., Semenova, A. A., & Lisitsyn, A. B. (2022). A mini review of antibacterial properties of Al2O3 nanoparticles. Nanomaterials, 12(15), 1–17. https://doi.org/10.3390/nano12152635
Guerrero-Arguero, I., Khan, S. R., Henry, B. M., Garcia-Vilanova, A., Chiem, K., Ye, C., et al. (2023). Mitigation of SARS-CoV-2 by using transition metal Nanozeolites and quaternary ammonium compounds as antiviral agents in suspensions and soft fabric materials. International Journal of Nanomedicine, 18(May), 2307–2324. https://doi.org/10.2147/IJN.S396669
Hameed, A. Z., & Muralidharan, K. (2023). Performance, emission, and catalytic activity analysis of AL2O3 and CEO2 Nano-additives on diesel engines using Mahua biofuel for a sustainable environment. ACS Omega, 8(6), 5692–5701. https://doi.org/10.1021/acsomega.2c07193
Han, B., Song, Y., Li, C., Yang, W., Ma, Q., Jiang, Z., et al. (2021a). Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: A double-blind, randomised, controlled, phase 1/2 clinical trial. The Lancet Infectious Diseases, 21(12), 1645–1653. https://doi.org/10.1016/S1473-3099(21)00319-4
Han, H. J., Nwagwu, C., Anyim, O., Ekweremadu, C., & Kim, S. (2021b). COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnology. International Immunopharmacology, 90(November 2020), 107247. https://doi.org/10.1016/j.intimp.2020.107247
Harish, V., Tewari, D., Gaur, M., Yadav, A. B., & Swaroop, S. (2022). Review on nanoparticles and nanostructured materials: Bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, and agro-food applications. Nanomaterials, 12.
Hassanpour, P., Panahi, Y., Ebrahimi-kalan, A., Akbarzadeh, A., Davaran, S., Nasibova, A. N., et al. (2018). Biomedical applications of aluminium oxide nanoparticles, 13, 1227–1231. https://doi.org/10.1049/mnl.2018.5070
Islam, M. S., Mubarak, M., & Lee, H. J. (2023). Hybrid nanostructured materials as electrodes in energy storage devices. Inorganics, 11(5), 1–21. https://doi.org/10.3390/inorganics11050183
Ito, T., Matsuda, Y., Jinba, T., Asai, N., Shimizu, T., & Shingubara, S. (2017). Fabrication and characterization of nano porous lattice biosensor using anodic aluminum oxide substrate. Japanese Journal of Applied Physics, 56(6), 06GG02. https://doi.org/10.7567/JJAP.56.06GG02/XML
Jampa, S., Ratanatawanate, C., Pimtong, W., Aueviriyavit, S., Chantho, V., Sillapaprayoon, S., et al. (2022). Transparent anti-SARS COV-2 film from copper(I) oxide incorporated in zeolite nanoparticles. ACS Applied Materials and Interfaces, 14(46), 52334–52346. https://doi.org/10.1021/acsami.2c12274
Kazantsev, S. O., Fomenko, A. N., & Korovin, M. S. (2016). Zeta potential change of neuro-2a tumor cells after exposure to alumina nanoparticles. AIP Conference Proceedings, 1760(1). https://doi.org/10.1063/1.4960244/782991
Kazantsev, S. O., Lozhkomoev, A. S., Glazkova, E. A., Gotman, I., Gutmanas, E. Y., Lerner, M. I., & Psakhie, S. G. (2018). SC. Materials Research Bulletin, 104, 97. https://doi.org/10.1016/j.materresbull.2018.04.011
Kermani, Z. R., Haghighi, S. S., Hajihosseinali, S., Fashami, A. Z., Akbaritouch, T., Akhtari, K., et al. (2018). Aluminium oxide nanoparticles induce structural changes in tau and cytotoxicity of the neuroblastoma cell line. International Journal of Biological Macromolecules, 120(Pt A), 1140–1148. https://doi.org/10.1016/J.IJBIOMAC.2018.08.182
Khan, I., Saeed, K., & Khan, I. (2019). Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry, 12(7), 908–931. https://doi.org/10.1016/J.ARABJC.2017.05.011
Khan, Y., Sadia, H., Ali Shah, S. Z., Khan, M. N., Shah, A. A., Ullah, N., et al. (2022). Classification, synthetic, and characterization approaches to nanoparticles, and their applications in various fields of nanotechnology: A review. Catalysts, 12(11). https://doi.org/10.3390/catal12111386
Kong, J., Chao, B., Wang, T., & Yan, Y. (2012). Preparation of ultrafine spherical AlOOH and Al2O3 powders by aqueous precipitation method with mixed surfactants. Powder Technology, 229, 7–16. https://doi.org/10.1016/J.POWTEC.2012.05.024
La Flamme, K. E., Popat, K. C., Leoni, L., Markiewicz, E., La Tempa, T. J., Roman, B. B., et al. (2007). Biocompatibility of nanoporous alumina membranes for immunoisolation. Biomaterials, 28(16), 2638–2645. https://doi.org/10.1016/J.BIOMATERIALS.2007.02.010
Lakshmi, K. C. S., & Vedhanarayanan, B. (2023). High-performance supercapacitors: A comprehensive review on paradigm shift of conventional energy storage devices. Batteries, 9(4). https://doi.org/10.3390/batteries9040202
Lee, J. H., Hwang, K. S., Jang, S. P., Lee, B. H., Kim, J. H., Choi, S. U. S., & Choi, C. J. (2008). Effective viscosities and thermal conductivities of aqueous nanofluids containing low volume concentrations of Al2O3 nanoparticles. International Journal of Heat and Mass Transfer, 51(11–12), 2651–2656. https://doi.org/10.1016/j.ijheatmasstransfer.2007.10.026
Leung, S. F., Zhang, Q., Xiu, F., Yu, D., Ho, J. C., Li, D., & Fan, Z. (2014). Light management with nanostructures for optoelectronic devices. Journal of Physical Chemistry Letters, 5(8), 1479–1495. https://doi.org/10.1021/jz500306f
Li, H., Li, Y., Jiao, J., & Hu, H. M. (2011). Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response. Nature Nanotechnology, 6(10), 645–650. https://doi.org/10.1038/nnano.2011.153
Li, X., Aldayel, A. M., & Cui, Z. (2014). Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles. Journal of Controlled Release, 173(1), 148–157. https://doi.org/10.1016/j.jconrel.2013.10.032
Li, Y., Xiao, Y., Chen, Y., & Huang, K. (2020). Nano-based approaches in the development of antiviral agents and vaccines. Life Sciences, 265, 118761.
Liu, X., Luo, L., Ding, Y., & Xu, Y. (2011). Amperometric biosensors based on alumina nanoparticles-chitosan-horseradish peroxidase nanobiocomposites for the determination of phenolic compounds. Analyst, 136(4), 696–701. https://doi.org/10.1039/C0AN00752H
Lu, Y., & Liu, G. (2022). Nano alum: A new solution to the new challenge. Human Vaccines and Immunotherapeutics, 18(5). https://doi.org/10.1080/21645515.2022.2060667
Malik, P., Gupta, R., Malik, V., & Ameta, R. K. (2021). Emerging nanomaterials for improved biosensing. Measurement: Sensors, 16, 100050. https://doi.org/10.1016/J.MEASEN.2021.100050
Mallamace, F., Nazarizadeh, A., Staudacher, A. H., Wittwer, N. L., Turnbull, T., Brown, M. P., & Kempson, I. (2022). Aluminium nanoparticles as efficient adjuvants compared to their microparticle counterparts: Current progress and perspectives. International Journal of Molecular Sciences, 23. https://doi.org/10.3390/ijms23094707
Manikandan, V., Jayanthi, P., Priyadharsan, A., Vijayaprathap, E., Anbarasan, P. M., & Velmurugan, P. (2019). Green synthesis of pH-responsive Al2O3 nanoparticles: Application to rapid removal of nitrate ions with enhanced antibacterial activity. Journal of Photochemistry and Photobiology A: Chemistry, 371, 205–215. https://doi.org/10.1016/J.JPHOTOCHEM.2018.11.009
Manyasree, D., Kiranmayi, P., & Ravi Kumar, R. V. S. N. (2018). Sythesis, characterization and antibacterial activity of aluminium oxide nanoparticles. International Journal of Pharmacy and Pharmaceutical Sciences, 10(1), 32. https://doi.org/10.22159/ijpps.2018v10i1.20636
Mao, L., Chen, Z., Wang, Y., & Chen, C. (2021). Design and application of nanoparticles as vaccine adjuvants against human corona virus infection. Journal of Inorganic Biochemistry, 219(March), 111454. https://doi.org/10.1016/j.jinorgbio.2021.111454
Martin, C., Nourian, A., Babaie, M., & Nasr, G. G. (2023). Geoenergy science and engineering environmental, health and safety assessment of nanoparticle application in drilling mud – Review. Geoenergy Science and Engineering, 226(April), 211767. https://doi.org/10.1016/j.geoen.2023.211767
Mohammed, A. A., Khodair, Z. T., & Khadom, A. A. (2020). Preparation, characterization and application of Al2O3 nanoparticles for the protection of boiler steel tubes from high temperature corrosion. Ceramics International. https://doi.org/10.1016/j.ceramint.2020.07.172
Mukherjee, K., & Acharya, K. (2018). Toxicological effect of metal oxide nanoparticles on soil and aquatic habitats. Archives of Environmental Contamination and Toxicology, 75(2), 175–186. https://doi.org/10.1007/S00244-018-0519-9/FIGURES/4
Mukherjee, A., Tc, P., & Chandrasekaran, N. (2011). Antimicrobial activity of aluminium oxide nanoparticles for potential clinical applications antimicrobial activity of aluminium oxide nanoparticles for potential clinical applications, (May 2014). Science against Microbial Pathogense Communicating Current Research and Technological Advances, 1, 245–251.
Muller, M. P., MacDougall, C., Lim, M., Armstrong, I., Bialachowski, A., Callery, S., et al. (2016). Antimicrobial surfaces to prevent healthcare-associated infections: A systematic review. Journal of Hospital Infection, 92(1), 7–13. https://doi.org/10.1016/j.jhin.2015.09.008
Naseem, T., & Durrani, T. (2021). The role of some important metal oxide nanoparticles for wastewater and antibacterial applications: A review. Environmental Chemistry and Ecotoxicology, 3, 59–75. https://doi.org/10.1016/J.ENCECO.2020.12.001
Nasiri, H., Motlagh, E. B., Khaki, J. V., & Zebarjad, S. M. (2012). Role of fuel/oxidizer ratio on the synthesis conditions of Cu – Al2 O3 nanocomposite prepared through solution combustion synthesis. Materials Research Bulletin, 47(11), 3676–3680. https://doi.org/10.1016/j.materresbull.2012.06.041
Naskar, A., & Kim, K. S. (2020). Recent advances in nanomaterial-based wound-healing therapeutics. Pharmaceutics, 12(6). https://doi.org/10.3390/pharmaceutics12060499
Niroumandrad, S., Rostami, M., & Ramezanzadeh, B. (2016). Effects of combined surface treatments of aluminium nanoparticle on its corrosion resistance before and after inclusion into an epoxy coating. Progress in Organic Coatings, 101, 486–501. https://doi.org/10.1016/j.porgcoat.2016.09.010
Park, Y. K., Tadd, E. H., Zubris, M., & Tannenbaum, R. (2005). Size-controlled synthesis of alumina nanoparticles from aluminum alkoxides. Materials Research Bulletin, 40(9), 1506–1512. https://doi.org/10.1016/J.MATERRESBULL.2005.04.031
Phan, H. T., & Haes, A. J. (2019). What does nanoparticle stability mean? Journal of Physical Chemistry C, 123(27), 16495–16507. https://doi.org/10.1021/acs.jpcc.9b00913
Pirhady Tavandashti, N., Molana Almas, S., & Esmaeilzadeh, E. (2021). Corrosion protection performance of epoxy coating containing alumina/PANI nanoparticles doped with cerium nitrate inhibitor on Al-2024 substrates. Progress in Organic Coatings, 152(3), 106133. https://doi.org/10.1016/j.porgcoat.2021.106133
Piriyawong, V., Thongpool, V., Asanithi, P., & Limsuwan, P. (2012). Preparation and characterization of alumina nanoparticles in deionized water using laser ablation technique. Journal of Nanomaterials. https://doi.org/10.1155/2012/819403
Rajan, Y. C., Inbaraj, B. S., & Chen, B. H. (2015). Synthesis and characterization of poly(γ-glutamic acid)-based alumina nanoparticles with their protein adsorption efficiency and cytotoxicity towards human prostate cancer cells. RSC Advances, 5(20), 15126–15139. https://doi.org/10.1039/C4RA10445E
Rajiv, S., Jerobin, J., Saranya, V., Nainawat, M., Sharma, A., Makwana, P., et al. (2016). Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro. Human and Experimental Toxicology, 35(2), 170–183. https://doi.org/10.1177/0960327115579208/FORMAT/EPUB
Ramírez, M., González, R. I., Baltazar, S. E., Rojas-Nunez, J., Allende, S., Valdivia, J. A., et al. (2019). Thermal stability of aluminum oxide nanoparticles: Role of oxygen concentration. Inorganic Chemistry Frontiers, 6(7), 1701–1706. https://doi.org/10.1039/c8qi01398e
Riquelme, A., Rodrigo, P., Escalera-Rodriguez, M. D., & Rams, J. (2022). Wear resistance of aluminum matrix composites’ coatings added on AA6082 aluminum alloy by laser cladding. Coatings, 12(1). https://doi.org/10.3390/coatings12010041
Sahoo, J., Sarkhel, S., Mukherjee, N., & Jaiswal, A. (2022). Nanomaterial-based antimicrobial coating for biomedical implants: New age solution for biofilm-associated infections. ACS Omega, 7(50), 45962–45980. https://doi.org/10.1021/acsomega.2c06211
Said, S., Mikhail, S., & Riad, M. (2020a). Materials science for energy technologies recent processes for the production of alumina nano-particles. Materials Science for Energy Technologies, 3, 344–363. https://doi.org/10.1016/j.mset.2020.02.001
Said, S., Mikhail, S., & Riad, M. (2020b). Recent processes for the production of alumina nano-particles. Materials Science for Energy Technologies, 3, 344–363. https://doi.org/10.1016/J.MSET.2020.02.001
Samrot, A. V., Prakash, N. R., & L. X. (2023). Nanoparticles induced oxidative damage in reproductive system and role of antioxidants on the induced toxicity. Life, 13(3), 1–17. https://doi.org/10.3390/life13030767
Sanità, G., Carrese, B., & Lamberti, A. (2020). Nanoparticle surface functionalization: How to improve biocompatibility and cellular internalization. Frontiers in Molecular Biosciences, 7(November). https://doi.org/10.3389/fmolb.2020.587012
Shah, M. A., Pirzada, B. M., Price, G., Shibiru, A. L., & Qurashi, A. (2022). Applications of nanotechnology in smart textile industry: A critical review. Journal of Advanced Research, 38, 55–75. https://doi.org/10.1016/j.jare.2022.01.008
Sharma, P., & Sharma, N. (2020). Antimicrobial activity of alumina nanoparticles synthesized by leaf extract of ocimum sanctum. International Journal of Engineering Applied Sciences and Technology, 5, 251–253.
Sharmin, S., Rahaman, M. M., Sarkar, C., Atolani, O., Islam, M. T., & Adeyemi, O. S. (2021). Nanoparticles as antimicrobial and antiviral agents: A literature-based perspective study. Heliyon, 7(3), e06456. https://doi.org/10.1016/j.heliyon.2021.e06456
Sliwinska, A., Kwiatkowski, D., Czarny, P., Milczarek, J., Toma, M., Korycinska, A., et al. (2015). Genotoxicity and cytotoxicity of ZnO and Al2O3 nanoparticles. Toxicology Mechanisms and Methods, 25(3), 176–183. https://doi.org/10.3109/15376516.2015.1006509
Smith, S. R., Rafati, R., Sharifi Haddad, A., Cooper, A., & Hamidi, H. (2018). Application of aluminium oxide nanoparticles to enhance rheological and filtration properties of water based muds at HPHT conditions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 537, 361–371. https://doi.org/10.1016/J.COLSURFA.2017.10.050
Tarlani, A., Isari, M., Khazraei, A., & Moghadam, M. E. (2017). New sol-gel derived aluminum oxide-ibuprofen nanocomposite as a controlled releasing medication. Nanomedicine Research Journal, 2(1), 28–35. https://doi.org/10.22034/NMRJ.2017.23256
Temiz, Ö., & Kargın, F. (2022). Toxicological impacts on antioxidant responses, stress protein, and genotoxicity parameters of aluminum oxide nanoparticles in the liver of Oreochromis niloticus. Biological Trace Element Research, 200(3), 1339–1346. https://doi.org/10.1007/S12011-021-02723-0/FIGURES/2
Torres, L. M. F. C., Almeida, M. T., Santos, T. L., Marinho, L. E. S., de Mesquita, J. P., da Silva, L. M., et al. (2019). Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity. Colloids and Surfaces B: Biointerfaces, 177(January), 94–104. https://doi.org/10.1016/j.colsurfb.2019.01.052
Volodina, K. V., Avnir, D., & Vinogradov, V. V. (2017). Alumina nanoparticle-assisted enzyme refolding: A versatile methodology for proteins renaturation. Scientific Reports, 7(1), 1–7. https://doi.org/10.1038/s41598-017-01436-6
Wang, F., Chen, M., Hu, X., Ye, R., Tan, C., & Ji, L. (2016). Ester-modified Cyclometalated iridium (III) complexes as anticancer agents. Nature Publishing Group, 210(November), 21–23. https://doi.org/10.1038/srep38954
Wang, L., Hu, C., & Shao, L. (2017). The-antimicrobial-activity-of-nanoparticles – present-situati. International Journal of Nanomedicine, 12, 1227–1249. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317269/pdf/ijn-12-1227.pdf
Yeap, S. P. (2018). Permanent agglomerates in powdered nanoparticles: Formation and future prospects. Powder Technology, 323, 51–59. https://doi.org/10.1016/J.POWTEC.2017.09.042
Yu, T. J., Li, P. H., Tseng, T. W., & Chen, Y. C. (2011). Multifunctional Fe3O4/alumina core/shell MNPs as photothermal agents for targeted hyperthermia of nosocomial and antibiotic-resistant bacteria. Nanomedicine, 6(8), 1353–1363. https://doi.org/10.2217/NNM.11.34
Zare, Y., Rhee, K. Y., & Hui, D. (2017). Influences of nanoparticles aggregation/agglomeration on the interfacial/interphase and tensile properties of nanocomposites. Composites Part B: Engineering, 122, 41–46. https://doi.org/10.1016/j.compositesb.2017.04.008
Zhang, T., He, P., Guo, D., Chen, K., Hu, Z., & Zou, Y. (2023). Research progress of aluminum phosphate adjuvants and their action mechanisms. Pharmaceutics, 15(6), 1756. https://doi.org/10.3390/pharmaceutics15061756
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Congreve, R.C., Quezada, C.P., Kokkarachedu, V. (2024). Aluminum Oxide Nanoparticles: Properties and Applications Overview. In: Kokkarachedu, V., Sadiku, R. (eds) Nanoparticles in Modern Antimicrobial and Antiviral Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-031-50093-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-031-50093-0_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-50092-3
Online ISBN: 978-3-031-50093-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)