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Atrial Fibrillation Mechanisms: A Contribution from Computational Modelling

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IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering (CLAIB 2022, CBEB 2022)

Abstract

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide; it is complex and can be multifactorial, and the underlying mechanisms are not yet completely understood, limiting treatment and reducing patients’ quality of life. Computational modelling has been shown to play an important role at improving current knowledge of AF. This study aims to simulate a normal heart condition as a planar wavefront propagation, and the three main AF mechanisms: ectopic foci, rotors and multiple and continuous intra-atrial reentries. This can be done through the OpenCARP platform, using its python framework called carputils, and applying Courtemanche’s human atrial action potential model. Action potential duration, local activation time and conduction velocity are estimated and compared, alongside the simulation images themselves. In summary, the mechanisms believed to underlie AF were reproduced here using 2D in-silico simulations performed in a standard computer. Action potential and cell-to-cell propagation variables had their roles identified in the mechanisms triggering and maintaining.

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Acknowledgements

The authors acknowledge the financial support from São Paulo Research Foundation (FAPESP), process 18/25606–2. M.E.T Antunes is performing 1-year undergraduate research (Edital: Edital 01/2021 - PIC/PIBIC/PIBITI/PIBIC-AF, process: 23006.015594/2021–31. I. Sandoval is supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES). J.G. Siles is supported by São Paulo Research Foundation (FAPESP), grant #2020/03601–9.

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The authors declare that they have no conflict of interest.

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Antunes, M.E.T., Campos, F.O., Sandoval, I., Siles, J.G., Uzelac, I., Salinet, J. (2024). Atrial Fibrillation Mechanisms: A Contribution from Computational Modelling. In: Marques, J.L.B., Rodrigues, C.R., Suzuki, D.O.H., Marino Neto, J., García Ojeda, R. (eds) IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering. CLAIB CBEB 2022 2022. IFMBE Proceedings, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-031-49401-7_14

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  • DOI: https://doi.org/10.1007/978-3-031-49401-7_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49400-0

  • Online ISBN: 978-3-031-49401-7

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