Skip to main content
  • 37 Accesses

Abstract

A short overview of the pathology of nonsyndromic cranial suture synostosis and syndromal craniosynostosis is given. Typical morphologies are illustrated. Included are definitions, incidences, pathogenesis, and mutational findings. Functional problems are listed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Cornelissen M, den Ottelander B, Rizopoulos D, van der Hulst R, Mink van der Molen A, van der Horst C, Delye H, van Veelen ML, Bonsel G, Mathijssen I. Increase of prevalence of craniosynostosis. J Craniomaxillofac Surg. 2016;44(9):1273–9.

    Article  PubMed  Google Scholar 

  • Graham JM, Smith DW. Metopic craniostenosis as a consequence of fetal head constraint: two interesting experiments of nature. Pediatrics. 1980;65:1000–2.

    Article  PubMed  Google Scholar 

  • Hunenko O, Karmacharya J, Ong G, Kirschner RE. Toward an understanding of nonsyndromic craniosynostosis: altered patterns of TGF-beta receptor and FGF receptor expression induced by intrauterine head constraint. Ann Plast Surg. 2001;46(5):546–53; discussion 553-4

    Article  CAS  PubMed  Google Scholar 

  • Ishii M, Sun J, Ting MC, Maxson RE. The development of the calvarial bones and sutures and the pathophysiology of craniosynostosis. Curr Top Dev Biol. 2015;115:131–56.

    Article  PubMed  Google Scholar 

  • Johnson D, Wilkie AO. Craniosynostosis. Eur J Hum Genet. 2011;19:369–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kirschner RE, Gannon FH, Xu J, Wang J, Karmacharya J, Bartlett SP, Whitaker LA. Craniosynostosis and altered patterns of fetal TGF-beta expression induced by intrauterine constraint. Plast Reconstr Surg. 2002;109(7):2338–46; discussion 2347-54

    Article  PubMed  Google Scholar 

  • Otto AW. Lehrbuch der pathologischen Anatomie des Menschen und der Thiere, vol. 1. Berlin: Rücker; 1830. p. 158–61.

    Google Scholar 

  • Persing JA. Management considerations in the treatment of craniosynostosis. Plast Reconstr Surg. 2008;121(4):1–11.

    Article  PubMed  Google Scholar 

  • Shin JH, Persing JA. Nonsyndromic craniosynostosis and deformational plagiocephaly. In: Thorne CH, Beasley RW, Aston SJ, Bartlett SP, Gurtner GC, Spear SL, editors. Grabb and Smith’s plastic surgery. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 226–36.

    Google Scholar 

  • Smartt JM, Karmacharya J, Gannon FH, Teixeira C, Mansfield K, Hunenko O, Shapiro IM, Kirschner RE. Intrauterine fetal constraint induces chondrocyte apoptosis and premature ossification of the cranial base. Plast Reconstr Surg. 2005;116:1363–9.

    Article  CAS  PubMed  Google Scholar 

  • Timberlake AT, Persing JA. Genetics of nonsyndromic craniosynostosis. Plast Reconstr Surg. 2018;141(6):1508–16.

    Article  CAS  PubMed  Google Scholar 

  • Timberlake AT, Junn A, Flores R, Staffenberg DA, Lifton RP, Persing JA. Genetic influence on neurodevelopment in nonsyndromic craniosynostosis. Plast Reconstr Surg. 2022;149(5):1157–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Upton J. Apert syndrome: classification and pathologic anatomy of limb anomalies. Clin Plast Surg. 1991;18:321–55.

    Article  CAS  PubMed  Google Scholar 

  • Virchow R. On dwarfism, particularly in Franconia, and on pathological skull shapes. Verh Phys Med Ges. 1851;2:230–70.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rasse, M. (2024). General Considerations. In: Surgery of Craniosynostosis and Related Midface Deformities. Springer, Cham. https://doi.org/10.1007/978-3-031-49102-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-49102-3_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49101-6

  • Online ISBN: 978-3-031-49102-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics