Skip to main content
SpringerLink
Log in

Newborn Neurobehavior and the Development of Infant Mental Health

  • Chapter
  • First Online:
WAIMH Handbook of Infant and Early Childhood Mental Health

  • 213 Accesses

Abstract

Newborn neurobehavior enables us to identify individual differences and temperament, differential susceptibility and to identify at-risk-infants. Neurobehavioral and biological (e.g., epigenetic) pathways set the stage for the “goodness-of-fit” between infant and caregiver manifest in dyadic interaction and mutual regulation. Preterm infants in particular struggle to develop mutual regulation because of the demands of internal/external stimulation. Changing caregiver behavior to better-fit infant neurobehavioral profiles in a dynamic repair-and-expand model can improve infant regulation and mental health.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Als, H., Lester, B. M., Tronick, E. Z., & Brazelton, T. B. (1982). Toward a research instrument for the assessment of preterm infants’ behavior (APIB). In H. E. Fitzgerald, B. M. Lester, & M. W. Yogman (Eds.), Theory and research in behavioral pediatrics (pp. 85–132). Plenum.

    Google Scholar 

  • Amiel-Tisson, C. (1968). Neurological evaluation of the maturity of newborn infants. Archives of Disease in Childhood, 43, 89–93.

    Article  Google Scholar 

  • André-Thomas, C. Y., & Saint-Anne Dargassies, S. (1952). Étudies neurologues sur le noreaune-et le jeune Nourison (Neurological studies in neonates and young infants). Masson et Ci e Livier Perrin.

    Google Scholar 

  • Als, H., Tronick, E., Adamson, L., & Brazelton, T. B. (1976). The behavior of the full‐term but underweight newborn infant. Developmental Medicine & Child Neurology, 18(5), 590–602.

    Google Scholar 

  • Bada, H. S., Sithisarn, T., Gibson, J., Garlitz, K., Caldwell, R., Capilouto, G., Li, Y., Leggas, M., & Breheny, P. (2015). Morphine versus clonidine for neonatal abstinence syndrome. Pediatrics, 135(2).

    Google Scholar 

  • Barros, M. C., Guinsburg, R., de Araújo Peres, C., Mitsuhiro, S., Chalem, E., & Laranjeira, R. R. (2006). Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period. The Journal of Pediatrics, 149(6), 781–787.

    Article  Google Scholar 

  • Barros, M. C. M., Mitsuhiro, S. S., Chalem, E., Laranjeira, R. R., & Guinsburg, R. (2011). Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers. Clinics, 66(9), 1597–1603.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bolten, M., Nast, I., Skrundz, M., Stadler, C., Hellhammer, D. H., & Meinlschmidt, G. (2013). Prenatal programming of emotion regulation: Neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels. Journal of Psychosomatic Research, 75(4), 351–357.

    Article  PubMed  Google Scholar 

  • Bowers, K., Ding, L., Yolton, K., Ji, H., Nidey, N., Meyer, J., Ammerman, R. T., Van Ginkel, J., & Folger, A. (2021). Pregnancy and Infant Development (PRIDE) – A preliminary observational study of maternal adversity and infant development. BMC Pediatrics, 21, 452–460.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brazelton, T. B. (1973). Neonatal behavioral assessment scale. In Clinics in developmental medicine, No 50. JB Lippincott.

    Google Scholar 

  • Chen, J., Li, H., Zhao, T., Chen, K., Chen, M.-H., Sun, Z., Xu, W., Maas, K., Lester, B. M., & Cong, X. S. (2023). the impact of early life experiences and gut microbiota on neurobehavioral development in preterm infants: A longitudinal cohort study. Microorganisms, 11(3), 814–830.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chin Foo, C. A., Dansereau, L. M., Hawes, K., Oliveira, E. L., & Lester, B. M. (2021). Improving the assessment of neonatal abstinence syndrome NAS. Children, 8(8), 685–696.

    Article  PubMed  PubMed Central  Google Scholar 

  • Conradt, E., Lester, B. M., Appleton, A. A., Armstrong, D. A., & Marsit, C. J. (2013a). The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior. Epigenetics, 8(12), 1321–1329.

    Article  PubMed  PubMed Central  Google Scholar 

  • Conradt, E., Sheinkopf, S. J., Lester, B. M., Tronick, E., Lagasse, L. L., Shankaran, S., Bada, H., Bauer, C. R., Whitaker, T. M., & Hammond, J. A. (2013b). Prenatal substance exposure: Neurobiological organization at one month. The Journal of Pediatrics, 163(4), 989–994.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Conradt, E., Beauchaine, T., Abar, B., Lagasse, L., Shankaran, S., Bada, H., Bauer, C., Whitaker, T., Hammond, J., & Lester, B. (2016). Early caregiving stress exposure moderates the relation between respiratory sinus arrhythmia reactivity at 1 month and biobehavioral outcomes at age 3: RSA reactivity and low-socioeconomic status. Psychophysiology, 53(1), 83–96.

    Article  PubMed  PubMed Central  Google Scholar 

  • Conradt, E., Shakiba, N., Ostlund, B., Terrell, S., Kaliush, P., Shakib, J. H., & Crowell, S. E. (2020). Prenatal maternal hair cortisol concentrations are related to maternal prenatal emotion dysregulation but not neurodevelopmental or birth outcomes. Developmental Psychobiology, 62(6), 758–767.

    Article  PubMed  PubMed Central  Google Scholar 

  • Coyle, M., Ferguson, A., LaGasse, L., Liu, J., & Lester, B. (2005). Neurobehavioral effects of treatment for opiate withdrawal. Archives of Disease in Childhood. Fetal and Neonatal Edition, 90(1), F73–F74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Coyle, M. G., Salisbury, A. L., Lester, B. M., Jones, H. E., Lin, H., Graf-Rohrmeister, K., & Fisher, G. (2012). Neonatal neurobehavior effects following buprenorphine versus methadone exposure. Addiction (Abingdon, England), 107(1), 63–73.

    Article  PubMed  Google Scholar 

  • Czynski, A. J., Davis, J. M., Dansereau, L. M., Engelhardt, B., Marro, P., Bogen, D. L., Hudak, M. L., Shenberger, J., Wachman, E. M., Oliveira, E. L., & Lester, B. M. (2020). Neurodevelopmental outcomes of neonates randomized to morphine or methadone for treatment of neonatal abstinence syndrome. The Journal of Pediatrics, 219, 146–151.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Barros, M. C. M., Mitsuhiro, S. S., Chalem, E., Laranjeira, R. R., & Guinsburg, R. (2013). Depression during gestation in adolescent mothers interferes with neonatal neurobehavior. Revista Brasileira de Psiquiatria, 35(4), 353–359.

    Article  PubMed  Google Scholar 

  • El-Farrash, R. A., Shinkar, D. M., Ragab, D. A., Salem, R. M., Saad, W. E., Farag, A. S., Salama, D. H., & Sakr, M. F. (2020). Longer duration of kangaroo care improves neurobehavioral performance and feeding in preterm infants: A randomized controlled trial. Pediatric Research, 87(4), 683–688.

    Article  PubMed  Google Scholar 

  • Everson, T. M., Marsit, C. J., Michael O’Shea, T., Burt, A., Hermetz, K., Carter, B. S., Helderman, J., Hofheimer, J. A., McGowan, E. C., Neal, C. R., Pastyrnak, S. L., Smith, L. M., Soliman, A., DellaGrotta, S. A., Dansereau, L. M., Padbury, J. F., & Lester, B. M. (2019). Epigenome-wide analysis identifies genes and pathways linked to neurobehavioral variation in preterm infants. Scientific Reports, 9(1), 6322.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fantz, R. L., Fagan, J. F., III, & Miranda, S. B. (1975). Early visual selectivity: As a function of pattern variables, previous exposure, age from birth and conception, and expected cognitive deficit. In Infant perception: From sensation to cognition (pp. 249–345). Elsevier.

    Chapter  Google Scholar 

  • Finnegan, L. P. (1986). Neonatal abstinence syndrome: Assessment and pharmacotherapy. In F. F. Rubatelli & B. Granati (Eds.), Neonatal therapy and update. Experta Medica.

    Google Scholar 

  • Flannery, T., Davis, J. M., Czynski, A. J., Dansereau, L. M., Oliveira, E. L., Camardo, S. A., & Lester, B. M. (2020). Neonatal abstinence syndrome severity index predicts 18-month neurodevelopmental outcome in neonates randomized to morphine or methadone. The Journal of Pediatrics, 227, 101–107.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gao, M. (Miranda), Ostlund, B., Brown, M. A., Kaliush, P. R., Terrell, S., Vlisides-Henry, R. D., Raby, K. L., Crowell, S. E., & Conradt, E. (2021). Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex. Development and Psychopathology, 33(5), 1554–1565.

    Article  PubMed  Google Scholar 

  • Green, B. B., Kappil, M., Lambertini, L., Armstrong, D. A., Guerin, D. J., Sharp, A. J., Lester, B. M., Chen, J., & Marsit, C. J. (2015). Expression of imprinted genes in placenta is associated with infant neurobehavioral development. Epigenetics, 10(9), 834–841.

    Article  PubMed  PubMed Central  Google Scholar 

  • Helderman, J., O’Shea, T. M., Dansereau, L., Check, J., Hofheimer, J. A., Smith, L. M., McGowan, E., Neal, C. R., Carter, B. S., Pastyrnak, S. L., Betz, B., Junewick, J., Borders, H. L., DellaGrotta, S. A., & Lester, B. M. (2022). Association of abnormal findings on neonatal cranial ultrasound with neurobehavior at neonatal intensive care unit discharge in infants born before 30 weeks’ gestation. JAMA Network Pen, 5(4).

    Google Scholar 

  • Hofheimer, J. A., Smith, L. M., McGowan, E. C., O’Shea, T. M., Carter, B. S., Neal, C. R., Helderman, J. B., Pastyrnak, S. L., Soliman, A., Dansereau, L. M., DellaGrotta, S. A., & Lester, B. M. (2020). Psychosocial and medical adversity associated with neonatal neurobehavior in infants born before 30 weeks’ gestation. Pediatric Research, 87(4), 721–729.

    Article  PubMed  Google Scholar 

  • Jones, H. E., O’Grady, K. E., Johnson, R. E., Velez, M., & Jansson, L. M. (2010). Infant neurobehavior following prenatal exposure to methadone or buprenorphine: Results from the neonatal intensive care unit network neurobehavioral scale. Substance Use & Misuse, 45(13), 2244–2257.

    Article  Google Scholar 

  • Karthik, L., Kumar, G., Keswani, T., Bhattacharyya, A., Chandar, S. S., & Bhaskara Rao, K. V. (2014). Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound. PLoS One, 9(3), e90972.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kiblawi, Z. N., Smith, L. M., Diaz, S. D., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., Arria, A., Huestis, M., Haning, W., Strauss, A., DellaGrotta, S., Dansereau, L. M., Neal, C., & Lester, B. (2014). Prenatal methamphetamine exposure and neonatal and infant neurobehavioral outcome: Results from the IDEAL study. Substance Abuse: Official Publication of the Association for Medical Education and Research in Substance Abuse, 35(1), 68–73.

    Article  Google Scholar 

  • Korner, A. F., & Thom, V. A. (1990). Neurobehavioral assessment of the preterm infant. The Psychological Corporation.

    Google Scholar 

  • LaGasse, L. L., Wouldes, T., Newman, E., Smith, L. M., Shah, R. Z., Derauf, C., Huestis, M. A., Arria, A. M., Grotta, S. D., Wilcox, T., & Lester, B. M. (2011). Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand. Neurotoxicology and Teratology, 33(1), 166–175.

    Article  PubMed  Google Scholar 

  • Law, K. L., Stroud, L. R., LaGasse, L. L., Niaura, R., Liu, J., & Lester, B. M. (2003). Smoking during pregnancy and newborn neurobehavior. Pediatrics, 111(6), 1318–1323.

    Article  PubMed  Google Scholar 

  • Lester, B. M., & Tronick, E. A. (2009).

    Google Scholar 

  • Lester, B. M., Tronick, E. Z., LaGasse, L., Seifer, R., Bauer, C. R., Shankaran, S., Bada, H. S., Wright, L. L., Smeriglio, V. L., Lu, J., Finnegan, L. P., & Maza, P. L. (2002). The maternal lifestyle study: Effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants. Pediatrics, 110(6), 1182–1192.

    Article  PubMed  Google Scholar 

  • Lester, B. M., Tronick, E. Z., & Brazelton, T. B. (2004). The neonatal intensive care unit network neurobehavioral scale procedures. Pediatrics, 11(3), 641–667.

    Article  Google Scholar 

  • Litzky, J. F., Deyssenroth, M. A., Everson, T. M., Lester, B. M., Lambertini, L., Chen, J., & Marsit, C. J. (2018). Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatric Research, 83(5), 1075–1083.

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu, J., Bann, C., Lester, B., Tronick, E., Abhik, D., Lagasse, L., Bauer, C., Shankaran, S., & Bada, H. (2010). Neonatal neurobehavior predicts medical and behavioral outcome. Pediatrics, 125(1), e90–e98.

    Article  PubMed  Google Scholar 

  • Marcus, S., Lopez, J. F., McDonough, S., MacKenzie, M. J., Flynn, H., Neal, C. R., Gahagan, S., Volling, B., Kaciroti, N., & Vazquez, D. M. (2011). Depressive symptoms during pregnancy: Impact on neuroendocrine and neonatal outcomes. Infant Behavior & Development, 34(1), 26–34.

    Article  Google Scholar 

  • Marsit, C. J., Maccani, M. A., Padbury, J. F., & Lester, B. M. (2012). Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. PLoS One, 7(3).

    Google Scholar 

  • Massaro, A. N., Evangelou, I., Brown, J., Fatemi, A., Vezina, G., McCarter, R., Glass, P., & Limperopoulos, C. (2015). Neonatal neurobehavior after therapeutic hypothermia for hypoxic ischemic encehphalopathy. Early Human Development, 91(10), 593–599.

    Article  PubMed  PubMed Central  Google Scholar 

  • McGowan, E. C., Hofheimer, J. A., O’Shea, T. M., Kilbride, H., Carter, B. S., Check, J., Helderman, J., Neal, C. R., Pastyrnak, S., Smith, L. M., Camerota, M., Dansereau, L. M., Della Grotta, S. A., & Lester, B. M. (2022). Analysis of neonatal neurobehavior and developmental outcomes among preterm infants. JAMA Network Pen, 5(7).

    Google Scholar 

  • Napiorkowski, B., Lester, B. M., Freier, M. C., Brunner, S., Dietz, L., Nadra, A., & Oh, W. (1996). Effects of in utero substance exposure on infant neurobehavior. Pediatrics, 98(1), 71–75.

    Article  PubMed  Google Scholar 

  • Ostlund, B. D., Olavson, K., Brown, M. A., Shakiba, N., Saenz, C., Crowell, S. E., & Conradt, E. (2021). Maternal mindfulness during pregnancy predicts newborn neurobehavior. Developmental Psychobiology, 63(6), e22131.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paquette, A. G., Lester, B. M., Lesseur, C., Armstrong, D. A., Guerin, D. J., Appleton, A. A., & Marsit, C. J. (2015). Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment. Epigenomics, 7(5), 767–779.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paquette, A. G., Houseman, E. A., Green, B. B., Lesseur, C., Armstrong, D. A., Lester, B., & Marsit, C. J. (2016). Regions of variable DNA methylation in human placenta associated with newborn neurobehavior. Epigenetics, 11(8), 603–613.

    Article  PubMed  PubMed Central  Google Scholar 

  • Peiper, A. (1928). Die Hirntätigkeit des Säuglings. Springer.

    Book  Google Scholar 

  • Picciolini, O., Porro, M., Meazza, A., Giannì, M. L., Rivoli, C., Lucco, G., Barretta, F., Bonzini, M., & Mosca, F. (2014). Early exposure to maternal voice: Effects on preterm infants development. Early Human Development, 90(6), 287–292.

    Article  PubMed  Google Scholar 

  • Prechtl, H. F. R. (1974). The behavioral states of the newborn infant. Brain Research, 76, 185–212.

    Article  PubMed  Google Scholar 

  • Prechtl, H. F., & Beintema, D. (1964). The neurological examination of the newborn infants (Clinics in Developmental Medicine). Heinemann.

    Google Scholar 

  • Rosenblith, J. (1961). The modified Graham behavior test for neonates: Test-retest reliability, normative data, and hypotheses for future work. Neonatology, 3(2–3), 174–192.

    Article  Google Scholar 

  • Salisbury, A. L., Wisner, K. L., Pearlstein, T., Battle, C. L., Stroud, L., & Lester, B. M. (2011). Newborn neurobehavioral patterns are differentially related to prenatal maternal Major Depressive Disorder and Serotonin Reuptake Inhibitor treatment. Depression and Anxiety, 28(11), 1008–1019.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sheinkopf, S. J., Lester, B. M., LaGasse, L. L., Seifer, R., Bauer, C. R., Shankaran, S., Bada, H. S., Poole, W. K., & Wright, L. L. (2006). Interactions between maternal characteristics and neonatal behavior in the prediction of parenting stress and perception of infant temperament. Journal of Pediatric Psychology, 31(1), 27–40.

    Article  PubMed  Google Scholar 

  • Sherrington, C. S. (1906). The integrative action of the nervous system. Scribner’s Sons.

    Google Scholar 

  • Smith, L. M., LaGasse, L. L., Derauf, C., Grant, P., Shah, R., Arria, A., Huestis, M., Haning, W., Strauss, A., Grotta, S. D., Fallone, M., Liu, J., & Lester, B. M. (2008). Prenatal methamphetamine use and neonatal neurobehavioral outcome. Neurotoxicology and Teratology, 30(1), 20–28.

    Article  PubMed  Google Scholar 

  • Smith, G. C., Gutovich, J., Smyser, C., Pineda, R., Newnham, C., Tjoeng, T. H., Vavasseur, C., Wallendorf, M., Neil, J., & Inder, T. (2011). NICU stress is associated with brain development in preterm infants. Annals of Neurology, 70(4), 541–549.

    Article  PubMed  PubMed Central  Google Scholar 

  • State Medical Cannabis Laws. (2023). National conference of state legislatures. Retrieved on May 1, 2023, from https://www.ncsl.org/health/state-medical-cannabis-laws

  • Stroud, L. R., Paster, R. L., Papandonatos, G. D., Niaura, R., Salisbury, A. L., Battle, C., Lagasse, L. L., & Lester, B. (2009). Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days. The Journal of Pediatrics, 154(1), 10–16.

    Article  PubMed  Google Scholar 

  • Stroud, L. R., Papandonatos, G. D., Salisbury, A. L., Phipps, M. G., Huestis, M. A., Niaura, R., Padbury, J. F., Marsit, C. J., & Lester, B. M. (2016). Epigenetic regulation of placental NR3C1: Mechanism underlying prenatal programming of infant neurobehavior by maternal smoking? Child Development, 87(1), 49–60.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stroud, L. R., Papandonatos, G. D., McCallum, M., Kehoe, T., Salisbury, A. L., & Huestis, M. A. (2018). Prenatal tobacco and marijuana co-use: Impact on newborn neurobehavior. Neurotoxicology and Teratology, 70, 28–39.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stroud, L. R., Papandonatos, G. D., Jao, N. C., Vergara-Lopez, C., Huestis, M. A., & Salisbury, A. L. (2020). Prenatal tobacco and marijuana co-use: Sex-specific influences on infant cortisol stress response. Neurotoxicology and Teratology, 79, 106882.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sucharew, H., Khoury, J. C., Xu, Y., Succop, P., & Yolton, K. (2012). NICU network neurobehavioral profiles predict developmental outcomes in a low risk sample. Paediatric and Perinatal Epidemiology, 26(4), 344–352.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sun, Z., Xu, W., Cong, X., Li, G., & Chen, K. (2020). Log-contrast regression with functional compositional predictors: Linking preterm infant’s gut microbiome trajectories to neurobehavioral outcome. The Annals of Applied Statistics, 14(3), 1535–1556.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tehrani, J. M., Kennedy, E., Tung, P. W., Burt, A., Hermetz, K., Punshon, T., Jackson, B. P., Hao, K., Chen, J., Karagas, M. R., Koestler, D. C., Lester, B., & Marsit, C. J. (2022). Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth. Pediatric Research.

    Google Scholar 

  • Tian, F.-Y., Everson, T. M., Lester, B., Punshon, T., Jackson, B. P., Hao, K., Lesseur, C., Chen, J., Karagas, M. R., & Marsit, C. J. (2020). Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts. Environment International, 137, 105508.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tronick, E. (2017). The caregiver–infant dyad as a buffer or transducer of resource enhancing or depleting factors that shape psychobiological development. Australian and New Zealand Journal of Family Therapy, 38(4), 561–572.

    Article  Google Scholar 

  • Tung, P. W., Burt, A., Karagas, M., Jackson, B. P., Punshon, T., Lester, B., & Marsit, C. J. (2022). Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study. Environmental Epidemiology, 6(1).

    Google Scholar 

  • Velez, M. L., Jansson, L. M., Schroeder, J., & Williams, E. (2009). Prenatal methadone exposure and neonatal neurobehavioral functioning. Pediatric Research, 66(6), 704–709.

    Article  PubMed  PubMed Central  Google Scholar 

  • Velez, M. L., McConnell, K., Spencer, N., Montoya, L., Tuten, M., & Jansson, L. M. (2018). Prenatal buprenorphine exposure and neonatal neurobehavioral functioning. Early Human Development, 117, 7–14.

    Article  PubMed  Google Scholar 

  • Wouldes, T. A., & Woodward, L. J. (2020). Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months. PLoS One, 15(10). e0240905.

    Google Scholar 

  • Xu, Y., Khoury, J. C., Sucharew, H., Dietrich, K., & Yolton, K. (2016). Low-level gestational exposure to mercury and maternal fish consumption: Associations with neurobehavior in early infancy. Neurotoxicology & Teratology, 4, 61–67.

    Article  Google Scholar 

  • Yolton, K., Khoury, J., Xu, Y., Succop, P., Lanphear, B., Bernert, J. T., & Lester, B. (2009). Low-level prenatal exposure to nicotine and infant neurobehavior. Neurotoxicology and Teratology, 31(6), 356–363.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yolton, K., Xu, Y., Strauss, D., Altaye, M., Calafat, A. M., & Khoury, J. (2011). Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology, 33(5), 558–566.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yolton, K., Xu, Y., Sucharew, H., Succop, P., Altaye, M., Popelar, A., Montesano, M. A., Calafat, A. M., & Khoury, J. C. (2013). Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: A prospective study. Environmental Health, 12, 79.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang, X., Spear, E., Gennings, C., Curtin, P. C., Just, A. C., Bragg, J. B., & Stroustrup, A. (2020). The association of prenatal exposure to intensive traffic with early preterm infant neurobehavioral development as reflected by the NICU Network Neurobehavioral Scale (NNNS). Environmental Research, 183, 109204.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang, X., Spear, E., Hsu, H. H. L., Gennings, C., & Stroustrup, A. (2022). NICU-based stress response and preterm infant neurobehavior: exploring the critical windows for exposure. Pediatric research, 92(5), 1470–1478.

    Google Scholar 

Download references

Acknowledgment

Acknowledgments: Funded in part, by National Institute of Child Health & Human Development (NICHD) grant R01HD072267 to BML

Author information

Authors and Affiliations

  1. Departments of Psychiatry and Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA

    Barry M. Lester

  2. Department of Psychiatry, Duke University, Durham, NC, USA

    Elisabeth Conradt

  3. Departments of Psychiatry and Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA, USA

    Ed Tronick

Authors
  1. Barry M. Lester
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elisabeth Conradt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ed Tronick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Barry M. Lester .

Editor information

Editors and Affiliations

  1. Departments of Pediatrics and Psychiatry, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Joy D. Osofsky

  2. Department of Psychology, Michigan State University, DeWitt, MI, USA

    Hiram E. Fitzgerald

  3. Department of Child and Adolescent Psychiatry at the Bar Ilan University Azrieli Medical School, Safed, Israel

    Miri Keren

  4. Department of Child Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

    Kaija Puura

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lester, B.M., Conradt, E., Tronick, E. (2024). Newborn Neurobehavior and the Development of Infant Mental Health. In: Osofsky, J.D., Fitzgerald, H.E., Keren, M., Puura, K. (eds) WAIMH Handbook of Infant and Early Childhood Mental Health. Springer, Cham. https://doi.org/10.1007/978-3-031-48627-2_10

Download citation

Publish with us

Policies and ethics

Search

Navigation