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Understanding Spine Biologics for the Access Surgeon

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Lumbar Spine Access Surgery

Abstract

Fusion is one of the most common techniques in spine surgery used to treat spinal pathology. The goal of a fusion procedure is to obtain a stable construct, to limit pathologic motion, and to maintain deformity correction. While there has been significant advancement in a variety of intraoperative techniques and implant designs to help promote fusion, pseudarthrosis or non-fusion continues to be a common complication and can contribute to poorer patient outcomes and represents a large economic burden to the healthcare system. Biologics are increasingly essential to achieving successful fusion in the spine, and in the last two decades, numerous bone graft substitutes and biologics have come to market.

The purpose of this chapter is to review the background, benefits, and limitations of commonly utilized grafts and biologics including autologous bone, allograft, demineralized bone matrix, bone morphogenic protein, ceramics, and polypeptide-based compounds as well as autologous and allogenic stem cells and gene therapies.

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Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, University of California San Francisco, San Francisco, CA, USA

    Jay Shah

  2. Department of Orthopedic Surgery, NYU Langone, New York, NY, USA

    Naina Rao

  3. Southern California Orthopedic Institute, Bakersfield, CA, USA

    Rahul G. Samtani

Authors
  1. Jay Shah
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  2. Naina Rao
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  3. Rahul G. Samtani
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Editor information

Editors and Affiliations

  1. Aligned Orthopaedics, Bethesda, MD, USA

    Joseph R. O'Brien

  2. Department of Orthopedic Surgery, The George Washington University, Washington, DC, USA

    Jeffrey B. Weinreb

  3. Vascular Surgery, Inova Health System, Falls Church, VA, USA

    Joseph C. Babrowicz

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Shah, J., Rao, N., Samtani, R.G. (2023). Understanding Spine Biologics for the Access Surgeon. In: O'Brien, J.R., Weinreb, J.B., Babrowicz, J.C. (eds) Lumbar Spine Access Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-48034-8_28

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  • DOI: https://doi.org/10.1007/978-3-031-48034-8_28

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-48033-1

  • Online ISBN: 978-3-031-48034-8

  • eBook Packages: MedicineMedicine (R0)

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