Abstract
In this study, deformations, and principal stresses in ocular tissues, especially in the optic disc, under glaucoma conditions were investigated. Four models with different parameters were developed, and their results were compared. Although the models did not yield quantitatively similar results, critical areas in the tissues were found. In these result values, the possibility of the presence of glaucoma exists, contributing to the early detection of this disease. Deformation in ocular tissues and an increase in principal stresses in the optic disc under glaucoma conditions were demonstrated. This indicates that optic nerve cells lose their mechanical properties due to the presence of stress concentrators, affecting cellular nutrition and potentially leading to cell death over time. Despite the quantitative differences, the models shared critical areas due to the geometry of the eye. These findings expand the understanding of the effects of glaucoma on ocular tissues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Xie, L., et al.: Potential biomarkers for primary open-angle glaucoma identified by long noncoding RNA profiling in the aqueous humor. Am. J. Pathol. 189(4), 739–752 (2019)
Wang, X., et al.: Finite element analysis predicts large optic nerve head strains during horizontal eye movements. Invest. Ophthalmol. Vis. Sci. 57(6), 2452–2462 (2016)
Chan, M.P., et al.: Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study. Bmj. 358, j3889 (2017)
Whitmore, L.A., Medley, R.: Cómo entender y vivir con glaucoma (2013)
Tortora, G.J., Derrickson, B.: Principios de anatomía y fisiología. Médica Panamericana (2013)
Sivaswamy, J., Krishnadas, S., Chakravarty, A., Joshi, G., Tabish, A.S.: A comprehensive retinal image dataset for the assessment of glaucoma from the optic nerve head analysis. JSM Biomedical Imaging Data Papers 2(1), 1004 (2015)
Sigal, I.A.: Interactions between geometry and mechanical properties on the optic nerve head. Invest. Ophthalmol. Vis. Sci. 50(6), 2785–2795 (2009)
Grytz, R., et al.: Material properties of the posterior human sclera. J. Mech. Behav. Biomed. Mater. 29, 602–617 (2014)
Pérez, V.V., de Fez Saiz, D., Verdú, F.M.M.: Óptica fisiológica: modelo paraxial y compensación óptica del ojo. Universidad de Alicante (2003)
Atchison, D.A., Smith, G.: Optics of the Human Eye. Optics of the Human Eye (2000)
Puell, M.: Óptica fisiológica. El sistema óptico del ojo y la visión binocular. [Internet]. Versión Digital: 1-4135-6363-5. Universidad Complutense de Madrid: ISBN (2006). Citado 27 Jul 2015
Gonzalez, G.D.: Modelo del ojo humano basado en matrices ABCD (2008)
Calderín Pérez, B., Carbonell, G., Alfonso, R., Landín Sorí, M., Nápoles Padrón, E.: Aplicabilidad de la simulación computacional en la biomecánica del disco óptico. Revista Archivo Médico de Camagüey 19(1), 73–82 (2015)
Khan, A., Pope, J.M., Verkicharla, P.K., Suheimat, M., Atchison, D.A.: Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation. Biomed. Opt. Express 9(3), 1272–1282 (2018)
Norman, R.E., et al.: Dimensions of the human sclera: Thickness measurement and regional changes with axial length. Experimental Eye Research 90, 277–284 (2010)
Acknowledgments
This project owes its success to the invaluable assistance provided by Alicia Natalia Ruíz Ramos for her collaboration in the research and contribution to the design of the four models used in this study. We are deeply grateful to her.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Sustaita, Y.O.B., González, X.B.G., Vidal-Lesso, A. (2024). Ocular Biomechanics of Glaucoma. In: Flores Cuautle, J.d.J.A., et al. XLVI Mexican Conference on Biomedical Engineering. CNIB 2023. IFMBE Proceedings, vol 97. Springer, Cham. https://doi.org/10.1007/978-3-031-46936-7_6
Download citation
DOI: https://doi.org/10.1007/978-3-031-46936-7_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-46935-0
Online ISBN: 978-3-031-46936-7
eBook Packages: EngineeringEngineering (R0)