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Changes in the Gut Microbiome as Seen in Diabetes and Obesity

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Clinical Understanding of the Human Gut Microbiome

Abstract

Diabetes rates have risen to the point where 1 in 10 adults worldwide have diabetes, and obesity rates have more than tripled since 1975. These conditions are interrelated and multifactorial, and are also associated with multiple health complications. Evidence suggests that gut microbiota play critical roles in the maintenance of human health and that perturbations in the balance of microbial populations can precipitate shifts toward inflammatory states and metabolic dysfunction. While it is known that these perturbations can be caused by dietary changes, antibiotics, pollutants and other environmental factors, the precise mechanisms underlying the dynamic interplay between different gut microbial populations and their impacts on host metabolism are still being explored. Here, we focus on our current understanding of the multiple ways in which alterations in gut microbial populations contribute to the development of both diabetes and obesity, and highlight recent developments in key areas of research.

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Authors and Affiliations

  1. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, West Hollywood, CA, USA

    Gillian M. Barlow, Shreya Celly & Ruchi Mathur

  2. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Ruchi Mathur

Authors
  1. Gillian M. Barlow
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  2. Shreya Celly
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  3. Ruchi Mathur
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Correspondence to Ruchi Mathur .

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Editors and Affiliations

  1. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, West Hollywood, CA, USA

    Mark Pimentel

  2. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, West Hollywood, CA, USA

    Ruchi Mathur

  3. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, West Hollywood, CA, USA

    Gillian M. Barlow

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Barlow, G.M., Celly, S., Mathur, R. (2023). Changes in the Gut Microbiome as Seen in Diabetes and Obesity. In: Pimentel, M., Mathur, R., Barlow, G.M. (eds) Clinical Understanding of the Human Gut Microbiome. Springer, Cham. https://doi.org/10.1007/978-3-031-46712-7_5

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  • DOI: https://doi.org/10.1007/978-3-031-46712-7_5

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