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Mesenchymal Cells from Adipose Tissue

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Pearls and Pitfalls in Skin Ulcer Management

Abstract

Adipose-derived stem cells are autologous mesenchymal stem cells first identified by Zuk et al. in 2001 from processed lipoaspirates; ADSCs meet the minimum criteria proposed by the International Society for Cellular Therapy (ISCT) in 2006, with specific immunophenotypic characteristics. These cells possess paracrine activity, being able to secrete various growth factors such as b-FGF (basic fibroblast growth factor), VEGF (vascular endothelial growth factor), IGF-1 (insulin-like growth factor 1), HGF (hepatocyte growth factor), and TGF-b1 (transforming growth factor beta 1) and are also able to release cytokines (IL-6, IL-7, IL-8, IL-11 TNF-a), the factors G-CSF and M-CSF (granulocyte and macrophage colony-stimulating factors), adipokines, in response to inflammatory stimuli. ADSCs are capable of differentiating into multiple cell lines, both mesodermal (adipogenic differentiation, chondrogenic differentiation, osteogenic differentiation, myogenic differentiation and non-mesodermal (neuronal differentiation, hepatocyte differentiation, pancreatic differentiation, endothelial differentiation, epithelial differentiation, hematopoietic differentiation), thus playing an important role in regenerative medicine.

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Author information

Authors and Affiliations

  1. Plastic Surgery Unit, Campus Bio Medico University, Rome, Italy

    Paolo Persichetti, Giovanni Francesco Marangi, Carlo Mirra, Marco Gratteri & Lucrezia Arcari

Authors
  1. Paolo Persichetti
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  2. Giovanni Francesco Marangi
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  3. Carlo Mirra
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  4. Marco Gratteri
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  5. Lucrezia Arcari
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Corresponding author

Correspondence to Paolo Persichetti .

Editor information

Editors and Affiliations

  1. Unit of Plastic and Reconstructive Surgery, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy

    Michele Maruccia

  2. Plastic Surgery Unit, University of Trieste, Cattinara Hospital, Trieste, Italy

    Giovanni Papa

  3. Difficult Wound Healing Unit, Policlinico di Monza, Vercelli, Italy, Italy

    Elia Ricci

  4. Plastic and Reconstructive Surgery, University of Bari Aldo Moro, Bari, Italy

    Giuseppe Giudice

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Persichetti, P., Marangi, G.F., Mirra, C., Gratteri, M., Arcari, L. (2023). Mesenchymal Cells from Adipose Tissue. In: Maruccia, M., Papa, G., Ricci, E., Giudice, G. (eds) Pearls and Pitfalls in Skin Ulcer Management. Springer, Cham. https://doi.org/10.1007/978-3-031-45453-0_25

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  • DOI: https://doi.org/10.1007/978-3-031-45453-0_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-45452-3

  • Online ISBN: 978-3-031-45453-0

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