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Evidence-Based and Clinical Experimentation on Cell Therapy

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Pearls and Pitfalls in Skin Ulcer Management

Abstract

Several local and systemic conditions could lead to chronic ulcers. Remarkable improvements have been made in wound dressing technologies in the last few decades; nonetheless, the progressive aging of our society and incidence of chronic diseases are increasing the incidence of non-healing ulcers, with high social and healthcare costs. Many pathophysiological alterations could lead to wound healing impairment, including altered inflammatory response, difficult neoangiogenesis, and cell senescence. It is now understood how cell therapy can target these alterations in non-healing ulcers, providing active and healthy cells and regulating growth factors in a paracrine manner. This chapter aimed to present a brief overview of main cell therapy options while discussing currently available clinical evidence for cell therapy applied to ulcer management.

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Authors and Affiliations

  1. Plastic Surgery Unit, University of Trieste, Trieste, Italy

    Andrea Ferrari, Chiara Stocco & Giovanni Papa

  2. Department of Life Sciences, University of Trieste, Trieste, Italy

    Roberta Bulla

  3. ICGEB – International Center for Genetic Engineering and Biotechnology, Trieste, Italy

    Serena Zacchigna

  4. Plastic Surgery Clinic, Cattinara University Hospital, Trieste, Italy

    Giovanni Papa

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  1. Andrea Ferrari
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  2. Chiara Stocco
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  3. Roberta Bulla
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  4. Serena Zacchigna
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  5. Giovanni Papa
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Corresponding author

Correspondence to Giovanni Papa .

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Editors and Affiliations

  1. Unit of Plastic and Reconstructive Surgery, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy

    Michele Maruccia

  2. Plastic Surgery Unit, University of Trieste, Cattinara Hospital, Trieste, Italy

    Giovanni Papa

  3. Difficult Wound Healing Unit, Policlinico di Monza, Vercelli, Italy, Italy

    Elia Ricci

  4. Plastic and Reconstructive Surgery, University of Bari Aldo Moro, Bari, Italy

    Giuseppe Giudice

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Ferrari, A., Stocco, C., Bulla, R., Zacchigna, S., Papa, G. (2023). Evidence-Based and Clinical Experimentation on Cell Therapy. In: Maruccia, M., Papa, G., Ricci, E., Giudice, G. (eds) Pearls and Pitfalls in Skin Ulcer Management. Springer, Cham. https://doi.org/10.1007/978-3-031-45453-0_22

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