Abstract
Pasteurella multocida is one of the most common isolated bacteria from respiratory complex condition in rabbitries. Infection with this bacterium is characterized by a respiratory syndrome identified primarily by rhinitis (contagious coryza), by pneumonia, or by a rhinopneumonia complex. P. multocida is an opportunist and contagious microorganism mainly transmitted by direct contact and aerosol. Pasteurellosis is frequently endemic in rabbits in different countries and can cause considerable economic losses in rabbitries throughout the world due to high morbidity, poor performances, and mortality. Dissemination of metastatic and septicemic forms contributes to the establishment of infection and lesions in several body tissues and organs. Treatments with antibiotics are not fully effective and do not avoid relapses. The control of environmental factors such as air renewal and animals’ thermal comfort are crucial as prevention measures. Genetic selection of more resistant rabbits is, also, a new approach to reduce the prevalence of pasteurellosis since. This chapter highlights the main issues related to the diagnosis, control, and prevention of pasteurellosis in rabbits.
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References
Alam RTM, Fawzi EM, Alkhalf MI, Alansari WS, Aleya L, Abdel-Daim MM (2018) Anti-inflammatory, immunomodulatory, and antioxidant activities of allicin, norfloxacin, or their combination against Pasteurella multocida infection in male New Zealand rabbits. Oxidative Med Cell Longev 2018:1780956. https://doi.org/10.1155/2018/1780956
Al-Haddawi MH, Jasni S, Zamri-Saad M, Mutalib AR, Son R, Sheikh-Omar AR (2000) Ultrastructural observation of nasal and pulmonary intracellular Pasteurella multocida A:3 in rabbits. Vet Res Commun 24:153–167. https://doi.org/10.1023/a:1006452230452
Asway A, Ahmed A, Shalby H (2008) Bacteriological and serological studies on Pasteurella multocida infection in rabbits. Assiut Vet Med J 54:1–12. https://doi.org/10.21608/avmj.2008.175954
Coudert P, Rideaud P, Virag G, Cerrone A (2006) Pasteurellosis in rabbits. In: Maertens L, Coudert P (eds) Recent advances in rabbit science. ILVO, Melle, pp 147–162. ISBN: 978-92-898-0030-3
D’Amico F, Casalino G, Bozzo G, Camarda A, Lombardi R, Dimuccio MM, Circella E (2022) Spreading of Pasteurella multocida infection in a pet rabbit breeding and possible implications on healed bunnies. Vet Sci 9:301. https://doi.org/10.3390/vetsci9060301
Deeb BJ (2004) Respiratory disease and Pasteurellosis. In: Quesenberry KE, Carpenter JW (eds) Ferrets, rabbits, and rodents, 2nd edn. WB Saunders, St. Louis, Missouri, pp 172–182. isbn: 0-7216-9377-6. https://doi.org/10.1016/B0-72-169377-6/50019-8
Deeb BJ, DiGiacomo RF (2000) Respiratory diseases of rabbits. The veterinary clinics of North America. Exot Anim Pract 3:465–vii. https://doi.org/10.1016/s1094-9194(17)30082-8
Deeb BJ, DiGiacomo RF, Bernard BL, Silbernagel SM (1990) Pasteurella multocida and Bordetella bronchiseptica infections in rabbits. J Clin Microbiol 28:70–75. https://doi.org/10.1128/jcm.28.1.70-75.1990
DiGiacomo RF, Jones CD, Wathes CM (1987) Transmission of Pasteurella multocida in rabbits. Lab Anim Sci 37:621–623
Du C, Huang Y, Jiang J, Gao Z, Jia N, Yang S, Chen C, Ma S, Liang Y, Jiang B, Sang W, Wang P, Liang Y, Zhang Y, Zhou J, Chen S, Jongejan F, Song Z, Tong Y, Cao W (2020) A large-scale fatal outbreak of Pasteurella multocida among wild rodents in Southwestern China. J Biosaf Biosecurity 2:91–98. https://doi.org/10.1016/j.jobb.2020.07.001
El-Jakee JK, Moussa IM, Omran MS, Ahmed BM, Elgamal MA, Hemeg HA, Mubarak AS, Al-Maary KS, Kabli SA, Marouf SA, Haji Alhaaji J (2020) A novel bivalent pasteurellosis-RHD vaccine candidate adjuvanted with Montanide ISA70 protects rabbits from lethal challenge. Saudi J Biol Sci 27:996–1001. https://doi.org/10.1016/j.sjbs.2019.12.042
El-Sheikh SMA, Youssef FM, Mohamed HI, El-Saber Batiha G, Albrakati A, Galal AAA (2021) Efficacy of grape seed hydro-alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits. Vet Med Sci 7:923–934. https://doi.org/10.1002/vms3.446
EMA (2020) Categorisation of antibiotics for use in animals for prudent and responsible use. Accessed from https://www.ema.europa.eu/en/documents/report/infographic-categorisation-antibiotics-use-animals-prudent-responsible-use_en.pdf (30-03-2023)
EMA/CVMP/CHMP/682198/2017 – Committee for Medicinal Products for Veterinary use (CVMP), Committee for Medicinal Products for Human Use (CHMP): Categorisation of antibiotics in the European Union. Accessed from https://www.ema.europa.eu/en/documents/other/answer-request-european-commission-updating-scientific-advice-impact-public-health-animal-health-use_en.pdf. 12 March 2023
Espinosa J, Ferreras MC, Benavides J, Cuesta N, Pérez C, García Iglesias MJ, García Marín JF, Pérez V (2020) Causes of mortality and disease in rabbits and hares: a retrospective study. Animals 10:158. https://doi.org/10.3390/ani10010158
García-Alvarez A, Chaves F, Fernández A, Sanz C, Borobia M, Cid D (2015) An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association. Infect Genet Evol 34:81–87. https://doi.org/10.1016/j.meegid.2015.07.018
Gens KD, Singer RS, Dilworth TJ, Heil EL, Beaudoin AL (2022) Antimicrobials in animal agriculture in the United States: a multidisciplinary overview of regulation and utilization to foster collaboration: on behalf of the Society of Infectious Diseases Pharmacists. Open Forum Infect Dis 9:ofac542. https://doi.org/10.1093/ofid/ofac542
Gunia M, David I, Hurtaud J, Maupin M, Gilbert H, Garreau H (2015) Resistance to infectious diseases is a heritable trait in rabbits. J Anim Sci 93:5631–5638. https://doi.org/10.2527/jas.2015-9377
Gunia M, David I, Hurtaud J, Maupin M, Gilbert H, Garreau H (2018) Genetic parameters for resistance to non-specific diseases and production traits measured in challenging and selection environments; application to a rabbit case. Front Genet 9:467. https://doi.org/10.3389/fgene.2018.00467
Harper M, John M, Turni C, Edmunds M, St Michael F, Adler B, Blackall PJ, Cox AD, Boyce JD (2015) Development of a rapid multiplex PCR assay to genotype Pasteurella multocida strains by use of the lipopolysaccharide outer core biosynthesis locus. J Clin Microbiol 53:477–485. https://doi.org/10.1128/JCM.02824-14
Hedley J (2014) Respiratory disease. In: Meredith A, Lord B (eds) BSAVA manual of rabbit medicine. BSAVA, Gloucester, pp 160–167
Hu J, Li W, Qiao X, Li W, Xie K, Wang Y, Huang B, Zhao Q, Liu L, Fan X (2021) Characterization of microRNA profiles in Pasteurella multocida-infected rabbits and identification of miR-29-5p as a regulator of antibacterial immune response. Front Vet Sci 8:746638. https://doi.org/10.3389/fvets.2021.746638
Jaglic Z, Jeklova E, Leva L, Kummer V, Kucerova Z, Faldyna M, Maskova J, Nedbalcova K, Alexa P (2008) Experimental study of pathogenicity of Pasteurella multocida serogroup F in rabbits. Vet Microbiol 126:168–177. https://doi.org/10.1016/j.vetmic.2007.06.008
Jaglic Z, Jeklova E, Christensen H, Leva L, Register K, Kummer V, Kucerova Z, Faldyna M, Maskova J, Nedbalcova K (2011) Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera. Can J Vet Res 75:200–208
Kuhnert P, Christensen H (2008) Pasteurellaceae: biology, genomics and molecular aspects. Caister Academic Press, Norfolk. isbn: 978-1-913652-12-8
Langan GP, Lohmiller JJ, Swing SP, Wardrip CL (2000) Respiratory diseases of rodents and rabbits. The Veterinary Clinics of North America. Small Animal Pract 30:1309–1vii. https://doi.org/10.1016/s0195-5616(00)06009-5
Lennox AM (2012) Respiratory disease and pasteurellosis. In: Quesenberry KE, Carpenter JW (eds) Ferrets, rabbits, and rodents: clinical medicine and surgery, 3rd edn. WB Saunders, Philadelphia, pp 205–216. ISBN: 978-1-4160-6621-7
Martin TCS, Abdelmalek J, Yee B, Lavergne S, Ritter M (2018) Pasteurella multocida line infection: a case report and review of literature. BMC Infect Dis 18:420. https://doi.org/10.1186/s12879-018-3329-9
Massacci FR, Magistrali CF, Cucco L, Curcio L, Bano L, Mangili P, Scoccia E, Bisgaard M, Aalbæk B, Christensen H (2018) Characterization of Pasteurella multocida involved in rabbit infections. Vet Microbiol 213:66–72. https://doi.org/10.1016/j.vetmic.2017.11.023
Nassar SA, Mohamed AH, Soufy H, Nasr SM (2013) Protective effect of Egyptian propolis against rabbit pasteurellosis. Biomed Res Int 2013:163724. https://doi.org/10.1155/2013/163724
Oslan SNH, Tan JS, Yusoff AH, Sulaiman AZ, Awang MA, Lazim AM, Lim SJ, Oslan SN, Saad MZ, Ariff AB (2022) Pasteurellosis vaccine commercialization: physiochemical factors for optimum production. PRO 10:1248. https://doi.org/10.3390/pr10071248
Palócz O, Gál J, Clayton P, Dinya Z, Somogyi Z, Juhász C, Csikó G (2014) Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand white rabbits. BMC Vet Res 10:276. https://doi.org/10.1186/s12917-014-0276-6
Patiño P, Gallego C, Martíneza N, Rey A, Iregui C (2022) Intranasal instillation of Pasteurella multocida lipopolysaccharide in rabbits causes interstitial lung damage. Res Vet Sci 152:115–126. https://doi.org/10.1016/j.rvsc.2022.07.026
Peng Z, Wang X, Zhou R, Chen H, Wilson BA, Wu B (2019) Pasteurella multocida: genotypes and genomics. Microbiol Mol Biol Rev 83:e00014–e00019. https://doi.org/10.1128/MMBR.00014-19
Pomba C, Catry B, Edo JT, Jukes H (2018) Licensing and approval of antimicrobial agents for use in animals. Microbiology spectrum 6. https://doi.org/10.1128/microbiolspec.ARBA-0016-2017
Qiu R, Wei H, Hu B, Chen M, Song Y, Xu W, Fan Z, Wang F (2022) Experimental pathogenicity and comparative genome analysis of high- and low-virulence strains of rabbit-origin Pasteurella multocida. Comp Immunol Microbiol Infect Dis 90-91:101889. https://doi.org/10.1016/j.cimid.2022.101889
Shrestha M, Garreau H, Balmisse E, Bed'hom B, David I, Guitton E, Helloin E, Lenoir G, Maupin M, Robert R, Lantier F, Gunia M (2020) Genetic parameters of resistance to pasteurellosis using novel response traits in rabbits. Genetics, Selection, Evolution: GSE 52:34. https://doi.org/10.1186/s12711-020-00552-8
Stahel AB, Hoop RK, Kuhnert P, Korczak BM (2009) Phenotypic and genetic characterization of Pasteurella multocida and related isolates from rabbits in Switzerland. J Vet Diagn Investig 21:793–802. https://doi.org/10.1177/104063870902100605
Sumitha P, Sukumar K (2014) An outbreak of Klebsiella pneumoniae infection in a rabbit farm. Int J Curr Microbiol App Sci 3:789–790
Taylor JD, Fulton RW, Lehenbauer TW (2010) The epidemiology of bovine respiratory disease: what is the evidence for predisposing factors? Can Vet J 51:1095–1102
Wang J, Sang L, Sun S, Chen Y, Chen D, Xie X (2019) Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China. BMC Vet Res 15:438. https://doi.org/10.1186/s12917-019-2191-3
Wilson BA, Ho M (2013) Pasteurella multocida: From Zoonosis to Cellular Microbiology. Clin Microbiol Rev 26:631–655. https://doi.org/10.1128/CMR.00024-13
Yang W, Li M, Zhang C, Zhang X, Guo M, Wu Y (2022) Pathogenicity, colonization, and innate immune response to Pasteurella multocida in rabbits. BMC Vet Res 18:416. https://doi.org/10.1186/s12917-022-03517-9
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The authors thank Springer for the use of the AJE Digital Editing. This work was supported by projects UIDP/CVT/00772/2020 (CECAV) and LA/P/0059/2020 (AL4AnimalS), funded by the Portuguese Foundation for Science and Technology (FCT).
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Simões, J., Saraiva, S., da Conceição Medeiros Castro Fontes, M., Monteiro, J.M., Tavares, T. (2024). Respiratory Complex in Rabbits (Pasteurellosis). In: Simões, J., Monteiro, J.M. (eds) Veterinary Care of Farm Rabbits. Springer, Cham. https://doi.org/10.1007/978-3-031-44542-2_19
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