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FSDiffReg: Feature-Wise and Score-Wise Diffusion-Guided Unsupervised Deformable Image Registration for Cardiac Images

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 (MICCAI 2023)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 14229))

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Unsupervised deformable image registration is one of the challenging tasks in medical imaging. Obtaining a high-quality deformation field while preserving deformation topology remains demanding amid a series of deep-learning-based solutions. Meanwhile, the diffusion model’s latent feature space shows potential in modeling the deformation semantics. To fully exploit the diffusion model’s ability to guide the registration task, we present two modules: Feature-wise Diffusion-Guided Module (FDG) and Score-wise Diffusion-Guided Module (SDG). Specifically, FDG uses the diffusion model’s multi-scale semantic features to guide the generation of the deformation field. SDG uses the diffusion score to guide the optimization process for preserving deformation topology with barely any additional computation. Experiment results on the 3D medical cardiac image registration task validate our model’s ability to provide refined deformation fields with preserved topology effectively. Code is available at:

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This work was supported by the Hong Kong Innovation and Technology Fund under Project ITS/030/21 & PRP/041/22FX, as well as by Foshan HKUST Projects under Grants FSUST21-HKUST10E and FSUST21-HKUST11E.

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Correspondence to Xiaomeng Li .

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Qin, Y., Li, X. (2023). FSDiffReg: Feature-Wise and Score-Wise Diffusion-Guided Unsupervised Deformable Image Registration for Cardiac Images. In: Greenspan, H., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2023. MICCAI 2023. Lecture Notes in Computer Science, vol 14229. Springer, Cham.

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