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Simulation-Based Parameter Optimization for Fetal Brain MRI Super-Resolution Reconstruction

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 (MICCAI 2023)


Tuning the regularization hyperparameter \(\alpha \) in inverse problems has been a longstanding problem. This is particularly true in the case of fetal brain magnetic resonance imaging, where an isotropic high-resolution volume is reconstructed from motion-corrupted low-resolution series of two-dimensional thick slices. Indeed, the lack of ground truth images makes challenging the adaptation of \(\alpha \) to a given setting of interest in a quantitative manner. In this work, we propose a simulation-based approach to tune \(\alpha \) for a given acquisition setting. We focus on the influence of the magnetic field strength and availability of input low-resolution images on the ill-posedness of the problem. Our results show that the optimal \(\alpha \), chosen as the one maximizing the similarity with the simulated reference image, significantly improves the super-resolution reconstruction accuracy compared to the generally adopted default regularization values, independently of the selected reconstruction pipeline. Qualitative validation on clinical data confirms the importance of tuning this parameter to the targeted clinical image setting. The simulated data and their reconstructions are available at

This work is supported by the Swiss National Science Foundation through grants 182602 and 141283, and by the Eranet Neuron MULTIFACT project (SNSF 31NE30_203977). We acknowledge access to the facilities and expertise of the CIBM Center for Biomedical Imaging, a Swiss research center of excellence founded and supported by CHUV, UNIL, EPFL, UNIGE and HUG.

Priscille de Dumast and Thomas Sanchez contributed equally to this work. Hélène Lajous and Mertixell Bach Cuadra share senior authroship.

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de Dumast, P., Sanchez, T., Lajous, H., Bach Cuadra, M. (2023). Simulation-Based Parameter Optimization for Fetal Brain MRI Super-Resolution Reconstruction. In: Greenspan, H., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2023. MICCAI 2023. Lecture Notes in Computer Science, vol 14226. Springer, Cham.

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