Skip to main content

Robust Cervical Abnormal Cell Detection via Distillation from Local-Scale Consistency Refinement

  • Conference paper
  • First Online:
Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 (MICCAI 2023)

Abstract

Automated detection of cervical abnormal cells from Thin-prep cytologic test (TCT) images is essential for efficient cervical abnormal screening by computer-aided diagnosis system. However, the detection performance is influenced by noise samples in the training dataset, mainly due to the subjective differences among cytologists in annotating the training samples. Besides, existing detection methods often neglect visual feature correlation information between cells, which can also be utilized to aid the detection model. In this paper, we propose a cervical abnormal cell detection method optimized by a novel distillation strategy based on local-scale consistency refinement. Firstly, we use a vanilla RetinaNet to detect top-K suspicious cells and extract region-of-interest (ROI) features. Then, a pre-trained Patch Correction Network (PCN) is leveraged to obtain local-scale features and conduct further refinement for these suspicious cell patches. We design a classification ranking loss to utilize refined scores for reducing the effects of the noisy label. Furthermore, the proposed ROI-correlation consistency loss is computed between extracted ROI features and local-scale features to exploit correlation information and optimize RetinaNet. Our experiments demonstrate that our distillation method can greatly optimize the performance of cervical abnormal cell detection without changing the detector’s network structure in the inference. The code is publicly available at https://github.com/feimanman/Cervical-Abnormal-Cell-Detection.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bengtsson, E., Malm, P.: Screening for cervical cancer using automated analysis of pap-smears. In: Computational and Mathematical Methods in Medicine 2014 (2014)

    Google Scholar 

  2. Cao, L., et al.: A novel attention-guided convolutional network for the detection of abnormal cervical cells in cervical cancer screening. Med. Image Anal. 73, 102197 (2021)

    Article  Google Scholar 

  3. Chen, T., et al.: A task decomposing and cell comparing method for cervical lesion cell detection. IEEE Trans. Med. Imaging 41(9), 2432–2442 (2022)

    Article  Google Scholar 

  4. Contributors, M.: Mmyolo: Openmmlab yolo series toolbox and benchmark (2022)

    Google Scholar 

  5. Davey, E., et al.: Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review. Lancet 367(9505), 122–132 (2006)

    Article  Google Scholar 

  6. Gatys, L.A., Ecker, A.S., Bethge, M.: A neural algorithm of artistic style. arXiv preprint arXiv:1508.06576 (2015)

  7. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  8. Hu, J., Shen, L., Sun, G.: Squeeze-and-excitation networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 7132–7141 (2018)

    Google Scholar 

  9. Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)

  10. LeCun, Y., Bengio, Y., Hinton, G.: Deep learning. Nature 521(7553), 436–444 (2015)

    Article  Google Scholar 

  11. Liang, Y., et al.: Exploring contextual relationships for cervical abnormal cell detection. arXiv preprint arXiv:2207.04693 (2022)

  12. Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)

    Google Scholar 

  13. Lin, T.-Y., et al.: Microsoft COCO: common objects in context. In: Fleet, D., Pajdla, T., Schiele, B., Tuytelaars, T. (eds.) ECCV 2014. LNCS, vol. 8693, pp. 740–755. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10602-1_48

    Chapter  Google Scholar 

  14. Liu, Q., Yu, L., Luo, L., Dou, Q., Heng, P.A.: Semi-supervised medical image classification with relation-driven self-ensembling model. IEEE Trans. Med. Imaging 39(11), 3429–3440 (2020)

    Article  Google Scholar 

  15. Nayar, R., Wilbur, D.C. (eds.): The Bethesda System for Reporting Cervical Cytology. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-11074-5

    Book  Google Scholar 

  16. Redmon, J., Farhadi, A.: Yolov3: an incremental improvement. arXiv preprint arXiv:1804.02767 (2018)

  17. Ren, S., He, K., Girshick, R., Sun, J.: Faster r-cnn: towards real-time object detection with region proposal networks. In: Advances in Neural Information Processing Systems 28 (2015)

    Google Scholar 

  18. Saslow, D., et al.: American cancer society, American society for colposcopy and cervical pathology, and American society for clinical pathology screening guidelines for the prevention and early detection of cervical cancer. Am. J. Clin. Pathol. 137(4), 516–542 (2012)

    Article  Google Scholar 

  19. Schiffman, M., Castle, P.E., Jeronimo, J., Rodriguez, A.C., Wacholder, S.: Human papillomavirus and cervical cancer. Lancet 370(9590), 890–907 (2007)

    Article  Google Scholar 

  20. Stoler, M.H., Schiffman, M., et al.: Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ascus-lsil triage study. JAMA 285(11), 1500–1505 (2001)

    Article  Google Scholar 

  21. Sun, P., et al.: SparseR-CNN: end-to-end object detection with learnable proposals. arXiv preprint arXiv:2011.12450 (2020)

  22. Yi, L., Lei, Y., Fan, Z., Zhou, Y., Chen, D., Liu, R.: Automatic detection of cervical cells using dense-cascade R-CNN. In: Peng, Y., et al. (eds.) PRCV 2020. LNCS, vol. 12306, pp. 602–613. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-60639-8_50

    Chapter  Google Scholar 

  23. Zhou, M., et al.: Hierarchical pathology screening for cervical abnormality. Comput. Med. Imaging Graph. 89, 101892 (2021)

    Article  Google Scholar 

  24. Zhu, X., et al.: Hybrid ai-assistive diagnostic model permits rapid tbs classification of cervical liquid-based thin-layer cell smears. Nat. Commun. 12(1), 3541 (2021)

    Article  Google Scholar 

  25. Zhu, X., Su, W., Lu, L., Li, B., Wang, X., Dai, J.: Deformable detr: deformable transformers for end-to-end object detection. arXiv preprint arXiv:2010.04159 (2020)

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 62001292).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lichi Zhang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Fei, M. et al. (2023). Robust Cervical Abnormal Cell Detection via Distillation from Local-Scale Consistency Refinement. In: Greenspan, H., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2023. MICCAI 2023. Lecture Notes in Computer Science, vol 14225. Springer, Cham. https://doi.org/10.1007/978-3-031-43987-2_63

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-43987-2_63

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-43986-5

  • Online ISBN: 978-3-031-43987-2

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics