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Updates on the Use of Ozone Therapy in Patients with COVID-19. A Review

  • Conference paper
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6th International Conference on Nanotechnologies and Biomedical Engineering (ICNBME 2023)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 92))

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Abstract

To date, there are no specific antiviral treatment strategies for COVID-19 patients. Empiric approaches used for other viral infections wasn’t effective against SARS-CoV-2. Thus, some urgent therapeutic alternatives are still required. Ozone therapy could be favorable due to its effects. Therefore, authors conducted a comprehensive review to reassess the reported adjuvant clinical potency and the last medical approaches towards patients with SARS-CoV-2 virus or COVID-19. Relevant articles were searched in PubMed, Hinari and SpringerLink, National Center of Biotechnology Information, and Medline using keywords “COVID-19”, “SARS-CoV-2”, “ozone therapy”, “mechanisms of ozone”, and “biological effects of ozone”, as well as their combinations. A total of 475 publications found were compared to exclude duplicates. The collection was reviewed and articles were filtered by title and abstract content. The remaining articles were assessed in full to exclude case-control studies or articles without relevant conclusions. Finally, 49 relevant sources were selected as representative. Ozone therapy has shown various beneficial properties: antiviral, immunomodulatory, antioxidant, anti-inflammatory, and cytoprotective effects, that can be useful in managing tissue damage occurring in many inflammatory illnesses, including viral infections like SARS-CoV-2. It can enhance the respiratory parameters, blood gas indicators, overall health condition, leading to a faster patient recovery.

Despite encouraging preliminary data from ongoing clinical trials, as well as expert opinion, there is still not enough evidence to confirm that it is a viable treatment for patients with COVID-19.

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References

  1. Malik, P., et al.: Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evidence-based Med. 26, 107–108 (2021). https://doi.org/10.1136/BMJEBM-2020-111536

    Article  Google Scholar 

  2. Coronavirus disease (COVID-19), https://www.who.int/emergencies/diseases/novel-coronavirus-2019

  3. Fernández-Cuadros, M.E., María, Albaladejo-Florín, J., Peña-Lora, D., Álava-Rabasa, S., Susana Pérez-Moro, O.: Ozone (O3) and SARS-CoV-2: Physiological Bases and Their Therapeutic Possibilities According to COVID-19 Evolutionary Stage. https://doi.org/10.1007/s42399-020-00328-7/Published

  4. Şahin, M., Eryilmaz, F., Keser Şahin, H: Ozone therapy may be an option for COVID-19 patients. 2470–2472 (2021). https://doi.org/10.26355/eurrev_202103_25407

  5. Hernández, A., Viñals, M., Isidoro, T., Vilás, F.: Potential Role of Oxygen-Ozone Therapy in Treatment of COVID-19 Pneumonia. Am. J. Case Rep. 21, 1–6 (2020). https://doi.org/10.12659/AJCR.925849

  6. Yilmaz, N., Eren, E., Oz, C.: COVID-19 and Ozone. Cyprus J. Med. Sci. 5, 365–372 (2021). https://doi.org/10.5152/cjms.2020.2658

    Article  Google Scholar 

  7. Ricevuti, G., Franzini, M., Valdenassi, L.: Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures. Ozone Ther. 5, (2020). https://doi.org/10.4081/OZONE.2020.9014

  8. Heimfarth, L., Serafini, M.R., Martins-Filho, P.R., Quintans, J. de S.S., Quintans-Júnior, L.J.: Drug repurposing and cytokine management in response to COVID-19: A review. Int. Immunopharmacol. 88, (2020). https://doi.org/10.1016/J.INTIMP.2020.106947

  9. Da, D., Campos, S., Morais, J.P., Tim, C.R., Gomes, J.C., Assis, L.: Implications for the use of ozone (O3) in the adjuvant treatment of COVID-19. Res. Soc. Dev. 9, e579997508–e579997508 (2020). https://doi.org/10.33448/RSD-V9I9.7508

  10. Cattel, F., et al.: Ozone therapy in COVID-19: A narrative review. Virus Res. 291, (2021). https://doi.org/10.1016/J.VIRUSRES.2020.198207

  11. De Farias, J.B.F., De Farias, A.P.F., De Souza, A.G.: Ozone as a complement therapy in the treatment of COVID-19. Rev. Bras. Fisiol. do Exerc. cio. 19, 5–8 (2020). https://doi.org/10.33233/RBFE.V19I2.4116

  12. Ogut, E., Armagan, K.: Evaluation of the potential impact of medical ozone therapy on covid-19: a review study. Ozone Sci. Eng. (2022). https://doi.org/10.1080/01919512.2022.2065242

    Article  Google Scholar 

  13. Promoter of the study: NUOVA F.I.O. (Italian Oxygen-Ozone Federation), Marini, S., et al.: Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study. J. Biol. Regul. Homeost. Agents. 34, (2020). https://doi.org/10.23812/20-250-E-56

  14. Martínez-Sánchez, G.: Ozone Therapy for Prevention and Treatment of COVID-19. J. Explor. Res. Pharmacol. 000, 000–000 (2022). https://doi.org/10.14218/JERP.2022.00015

  15. Radvar, S., et al.: Using ozone therapy as an option for treatment of COVID-19 patients: a scoping review. Adv. Exp. Med. Biol. 1327, 151–160 (2021). https://doi.org/10.1007/978-3-030-71697-4_12

    Article  Google Scholar 

  16. Alberto Hernández, A., Vilás, F., Papadakos, P.J., Bergese, S.D., Vives, M.: Title: Ozone therapy for patients with COVID-19 pneumonia: preliminary report of a prospective case-control study. https://doi.org/10.1101/2020.06.03.20117994

  17. Martínez-Sánchez, G., Schwartz, A., Di Donna, V.: Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants. 9, (2020). https://doi.org/10.3390/antiox9050389

  18. Fernandez-Cuadros, M.E., Perez-Moro, O.S., Albaladejo-Florin, M.J., Entrambasaguas-Estepa, B., Alava-Rabasa, S.: Mid-Term Effectiveness of Ozone (O2-O3) Compared to Platelet-Rich Plasma (PRP) in the Management of Knee Osteoarthritis: A Randomized Parallel Controlled Trial. Middle East J. Rehabil. Heal. In: Press, 1–8 (2019). https://doi.org/10.5812/mejrh.74140

  19. Barbosa, R.B., et al.: Ozone therapy as a treatment option against COVID-19: a literature review. Res. Soc. Dev. 10, e469101321228–e469101321228 (2021). https://doi.org/10.33448/RSD-V10I13.21228

  20. Fernández-Cuadros, M.E., et al.: Compassionate use of rectal ozone (O3) in severe COVID-19 Pneumonia: a case-control study. SN Compr. Clin. Med. 3, 1185–1199 (2021). https://doi.org/10.1007/S42399-021-00849-9

    Article  Google Scholar 

  21. Wang, Y., et al.: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet (London, England). 395, 1569–1578 (2020). https://doi.org/10.1016/S0140-6736(20)31022-9

    Article  Google Scholar 

  22. Izadi, M., et al.: Ozone therapy for the treatment of COVID-19 pneumonia: a scoping review. Int. Immunopharmacol. 92, 1567–5769 (2021). https://doi.org/10.1016/j.intimp.2020.107307

    Article  Google Scholar 

  23. Rowen, R.J., Robins, H.: A Plausible “Penny” Costing Effective Treatment for Corona Virus - Ozone Therapy. J Infect Dis Epidemiol. 2020, 113 (2020). https://doi.org/10.23937/2474-3658/1510113

  24. Sharma, A., et al.: A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial. Int. Immunopharmacol. 96, (2021). https://doi.org/10.1016/J.INTIMP.2021.107743

  25. Cenci, A., Macchia, I., La Sorsa, V., Sbarigia, C., Di Donna, V., Pietraforte, D.: Mechanisms of Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2. Front. Microbiol. 13, (2022). https://doi.org/10.3389/FMICB.2022.871645/PDF

  26. Cuadros, M.E.F., Florín, M.J.A., Rabasa, S.Á., Lora, D.P., Moro, O.S.P.: Ozone and COVID-19: physiological bases and their therapeutic possibilities according to the evolutionary stage in SARS-CoV-2 infection. Rev. la Soc. Esp. del Dolor. 28, 27–36 (2021). https://doi.org/10.20986/RESED.2021.3810/2020

  27. Yaneva, G., Dimitrova, T., Ivanov, D., Ivanova, D., Ingilizova, G., Slavov, S.: MODERN APPLICATIONS OF OZONE FOR COVID-19 DISINFECTION AND TREATMENT. J. IMAB - Annu. Proceeding (Scientific Pap. 28, 4284–4288 (2022). https://doi.org/10.5272/JIMAB.2022281.4284

  28. Manjunath, S.N., Sakar, M., Katapadi, M., Geetha Balakrishna, R.: Recent case studies on the use of ozone to combat coronavirus: Problems and perspectives. Environ. Technol. Innov. 21, (2021). https://doi.org/10.1016/J.ETI.2020.101313

  29. Falcón, B.A., Fernández, J.L.C., Cepero, S.M., Yoshimoto, C.V.: Ozone therapy and its application in relation to the pathophysiology of COVID 19 disease. Panor. Cuba y Salud. 15, 104–107 (2020)

    Google Scholar 

  30. Yousefi, B., Banihashemian, S.Z., Feyzabadi, Z.K., Hasanpour, S., Kokhaei, P.: Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease, pp. 33–40 (2022). https://doi.org/10.4103/2045-9912.325989

  31. León Fernández, O.S., et al.: Medical ozone: the pharmacological mechanisms accounting for its effectiveness against COVID-19/SARS-COV-2. J. Med.-Clin. Res. Rev. ISSN 5(1–10), 2639–2944 (2021)

    Google Scholar 

  32. Chirumbolo, S., et al.: Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int. Immunopharmacol. 96, 107777 (2021). https://doi.org/10.1016/J.INTIMP.2021.107777

    Article  Google Scholar 

  33. Schwartz, Martínez-Sánchez: Potential use of ozone in SARS-CoV-2 / COVID-19. Int. Sci. Comm. Ozone Ther. (2020)

    Google Scholar 

  34. Chirumbolo, S., et al.: Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int. Immunopharmacol. 96, (2021). https://doi.org/10.1016/J.INTIMP.2021.107777

  35. Zheng, Z., Dong, M., Hu, K.: A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19. J. Med. Virol. 92, 2348–2350 (2020). https://doi.org/10.1002/JMV.26040

    Article  Google Scholar 

  36. Tricarico, G., Travagli, V.: The relationship between ozone and human blood in the course of a well-controlled, mild, and transitory oxidative eustress. Antioxidants. 10, 1946 (2021). https://doi.org/10.3390/antiox10121946

    Article  Google Scholar 

  37. Morrison, C., et al.: Critical review and research needs of ozone applications related to virus inactivation: potential implications for SARS-CoV-2. Ozone Sci. Eng. 43, 2–20 (2021). https://doi.org/10.1080/01919512.2020.1839739

    Article  Google Scholar 

  38. Fernández-cuadros, M., Albaladejo-florín, M.J., Pérez-moro, O., Rodríguez-de-cía, J.: Multicentric Study on the Effect of Rectal Ozone on COVID-19 : the Spanish and Slovakian Experience. (2022). https://doi.org/10.20944/preprints202203.0272.v1

  39. Fernández-Cuadros, M.E., et al.: Effect of rectal ozone (O3) in Severe COVID-19 Pneumonia: preliminary results. SN Compr. Clin. Med. 2, 1328–1336 (2020). https://doi.org/10.1007/s42399-020-00374-1

    Article  Google Scholar 

  40. Tascini, C., et al.: Monte, Amato: Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single centre experience. Intern. Emerg. Med. 16, 669–675 (2021). https://doi.org/10.1007/s11739-020-02542-6

    Article  Google Scholar 

  41. Franzini, M., et al.: Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int. Immunopharmacol. 88, (2020). https://doi.org/10.1016/J.INTIMP.2020.106879

  42. Çolak, Ş., et al.: Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID‐19. Int. J. Clin. Pract. 75, (2021). https://doi.org/10.1111/ijcp.14321

  43. Peña-Lora, D.Y., Albaladejo-Florín, M.J., Fernández-Cuadros, M.E.: Usefulness of rectal ozonetherapy in a geriatric patient with severe COVID-19 pneumonia. Rev. Esp. Geriatr. Gerontol. 55, 362–364 (2020). https://doi.org/10.1016/J.REGG.2020.07.005

    Article  Google Scholar 

  44. Shah, M., et al.: Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). Int. Immunopharmacol. 91, (2021). https://doi.org/10.1016/J.INTIMP.2020.107301

  45. Sozio, E., et al.: CORonavirus-19 mild to moderate pneumonia management with blood ozonization in patients with respiratory failure (CORMOR) multicentric prospective randomized clinical trial. Int. Immunopharmacol. 98, (2021). https://doi.org/10.1016/J.INTIMP.2021.107874

  46. Schwartz, A., Martínez-Sánchez, G., de Lucía, A.M., Viana, S.M., Constanta, A.M.: Complementary application of the ozonized saline solution in mild and severe patients with pneumonia COVID-19: A non-randomized pilot study. J. Pharm. Pharmacogn. Res. 9, 126–146 (2021). https://doi.org/10.56499/JPPRES20.971_9.2.126

  47. Setyo Budi, D., et al.: Ozone as an adjuvant therapy for COVID-19: A systematic review and meta-analysis. Int. Immunopharmacol. 110, (2022). https://doi.org/10.1016/J.INTIMP.2022.109014

  48. Robert Jay, R., Howard, R.: A plausible penny costing effective treatment for corona virus - ozone therapy. J. Infect. Dis. Epidemiol. 6, (2020). https://doi.org/10.23937/2474-3658/1510113

  49. Chirumbolo, S., et l.: The Mito-Hormetic mechanisms of ozone in the clearance of SARS-CoV2 and in the COVID-19 Therapy. Biomed. 10, (2022). https://doi.org/10.3390/BIOMEDICINES10092258

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Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care, Emergency Medicine Institute, Chișinau, Republic of Moldova

    Natalia Cernei & Cristina Trofimov

  2. Department of Human Physiology and Biophysics, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chișinau, Republic of Moldova

    Ion Grabovschi & Oleg Arnaut

  3. “Valeriu Ghereg” Department of Anesthesiology and Intensive Care, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chișinau, Republic of Moldova

    Ruslan Baltaga

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  1. Natalia Cernei
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  2. Cristina Trofimov
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Correspondence to Natalia Cernei .

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  1. Department of Microelectronics and Biomedical Engineering, Technical University of Moldova, Chisinau, Moldova

    Victor Sontea

  2. Academy of Sciences of Moldova, Chisinau, Moldova

    Ion Tiginyanu

  3. Department of Microelectronics and Biomedical Engineering, Technical University of Moldova, Chisinau, Moldova

    Serghei Railean

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Cernei, N., Trofimov, C., Grabovschi, I., Baltaga, R., Arnaut, O. (2024). Updates on the Use of Ozone Therapy in Patients with COVID-19. A Review. In: Sontea, V., Tiginyanu, I., Railean, S. (eds) 6th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2023. IFMBE Proceedings, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-031-42782-4_40

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  • DOI: https://doi.org/10.1007/978-3-031-42782-4_40

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