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Treatment of Brain Arteriovenous Malformations

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Advances and Technical Standards in Neurosurgery

Part of the book series: Advances and Technical Standards in Neurosurgery ((NEUROSURGERY,volume 49))

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Abstract

Brain arteriovenous malformations (AVMs) are a rare entity of vascular anomalies, characteristic of anatomical shunting where arterial blood directly flows into the venous circulation. The main aim of the active treatment policy of brain AVMs is the prevention of haemorrhage. There are well-established treatment strategies that continually improve in their safety and efficacy, primarily due to the advances in imaging modalities, targeted and novel techniques, the development of alternative treatment approaches, and even better experience with the disease itself. There are interesting imaging novelties that may be prospectively applicable in the decision-making and planning of the most effective treatment approach for individual patients with intracranial AVM. Surgery is often considered the first-line treatment; however, each patient should be evaluated individually, and the risks of the active treatment policy should not overcome the benefits of the spontaneous natural history of the disease. All treatment modalities, i.e., surgery, radiosurgery, endovascular embolization, and observation, are justified but need to be meticulously selected for each individual patient in order to deliver the best treatment outcome. This chapter deals with historical and currently applied dogmas, followed by introductions of advances in each available treatment modality of AVM management.

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References

  1. McCormick WF. The pathology of vascular (“arteriovenous”) malformations. J Neurosurg. 1966;24(4):807–16.

    Article  CAS  PubMed  Google Scholar 

  2. Valavanis A, Yaşargil MG. The endovascular treatment of brain arteriovenous malformations. Adv Tech Stand Neurosurg. 1998;24:131–214. https://doi.org/10.1007/978-3-7091-6504-1_4.

    Article  CAS  PubMed  Google Scholar 

  3. Beneš V, Bradáč O. Brain arteriovenous malformations: pathogenesis, epidemiology, diagnosis, treatment and outcome. Berlin: Springer; 2017.

    Book  Google Scholar 

  4. Rammos SK, Gardenghi B, Bortolotti C, Cloft HJ, Lanzino G. Aneurysms associated with brain arteriovenous malformations. Am J Neuroradiol. 2016;37(11):1966–71. https://doi.org/10.3174/ajnr.A4869.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ogilvy CS, Stieg PE, Awad I, Brown RD Jr, Kondziolka D, Rosenwasser R, et al. AHA scientific statement: recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association. Stroke. 2001;32(6):1458–71. https://doi.org/10.1161/01.str.32.6.1458.

    Article  CAS  PubMed  Google Scholar 

  6. Redekop G, TerBrugge K, Montanera W, Willinsky R. Arterial aneurysms associated with cerebral arteriovenous malformations: classification, incidence, and risk of hemorrhage. J Neurosurg. 1998;89(4):539–46. https://doi.org/10.3171/jns.1998.89.4.0539.

    Article  CAS  PubMed  Google Scholar 

  7. Stapf C, Mast H, Sciacca RR, Choi JH, Khaw AV, Connolly ES, et al. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006;66(9):1350–5. https://doi.org/10.1212/01.wnl.0000210524.68507.87.

    Article  CAS  PubMed  Google Scholar 

  8. Piotin M, Ross IB, Weill A, Kothimbakam R, Moret J. Intracranial arterial aneurysms associated with arteriovenous malformations: endovascular treatment. Radiology. 2001;220(2):506–13. https://doi.org/10.1148/radiology.220.2.r01au09506.

    Article  CAS  PubMed  Google Scholar 

  9. Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, et al. Influence of patient age on angioarchitecture of brain arteriovenous malformations. Am J Neuroradiol. 2014;35(7):1376–80. https://doi.org/10.3174/ajnr.a3886.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Leblanc GG, Golanov E, Awad IA, Young WL. Biology of vascular malformations of the brain. Stroke. 2009;40(12):e694–702. https://doi.org/10.1161/strokeaha.109.563692.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Moftakhar P, Hauptman JS, Malkasian D, Martin NA. Cerebral arteriovenous malformations. Part 1: cellular and molecular biology. Neurosurg Focus. 2009;26(5):E10. https://doi.org/10.3171/2009.2.Focus09316.

    Article  PubMed  Google Scholar 

  12. Marchuk DA, Srinivasan S, Squire TL, Zawistowski JS. Vascular morphogenesis: tales of two syndromes. Hum Mol Genet. 2003;12 Spec No 1:R97–112. https://doi.org/10.1093/hmg/ddg103.

    Article  CAS  PubMed  Google Scholar 

  13. Bharatha A, Faughnan ME, Kim H, Pourmohamad T, Krings T, Bayrak-Toydemir P, et al. Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagic telangiectasia: quantitative assessment. Stroke. 2012;43(1):72–8. https://doi.org/10.1161/strokeaha.111.629865.

    Article  PubMed  Google Scholar 

  14. Komiyama M. Pathogenesis of brain arteriovenous malformations. Neurol Med Chir (Tokyo). 2016;56(6):317–25. https://doi.org/10.2176/nmc.ra.2016-0051.

    Article  PubMed  Google Scholar 

  15. Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, et al. Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery. 2007;61(4):731–9. https://doi.org/10.1227/01.Neu.0000298901.61849.A4; discussion 40.

    Article  PubMed  Google Scholar 

  16. Mouchtouris N, Jabbour PM, Starke RM, Hasan DM, Zanaty M, Theofanis T, et al. Biology of cerebral arteriovenous malformations with a focus on inflammation. J Cereb Blood Flow Metab. 2015;35(2):167–75. https://doi.org/10.1038/jcbfm.2014.179.

    Article  CAS  PubMed  Google Scholar 

  17. Rothbart D, Awad IA, Lee J, Kim J, Harbaugh R, Criscuolo GR. Expression of angiogenic factors and structural proteins in central nervous system vascular malformations. Neurosurgery. 1996;38(5):915–24. https://doi.org/10.1097/00006123-199605000-00011; discussion 24–5.

    Article  CAS  PubMed  Google Scholar 

  18. Crawford PM, West CR, Chadwick DW, Shaw MD. Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry. 1986;49(1):1–10. https://doi.org/10.1136/jnnp.49.1.1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Itoyama Y, Uemura S, Ushio Y, Kuratsu J, Nonaka N, Wada H, et al. Natural course of unoperated intracranial arteriovenous malformations: study of 50 cases. J Neurosurg. 1989;71(6):805–9. https://doi.org/10.3171/jns.1989.71.6.0805.

    Article  CAS  PubMed  Google Scholar 

  20. Spetzler RF, Hargraves RW, McCormick PW, Zabramski JM, Flom RA, Zimmerman RS. Relationship of perfusion pressure and size to risk of hemorrhage from arteriovenous malformations. J Neurosurg. 1992;76(6):918–23. https://doi.org/10.3171/jns.1992.76.6.0918.

    Article  CAS  PubMed  Google Scholar 

  21. Langer DJ, Lasner TM, Hurst RW, Flamm ES, Zager EL, King JT Jr. Hypertension, small size, and deep venous drainage are associated with risk of hemorrhagic presentation of cerebral arteriovenous malformations. Neurosurgery. 1998;42(3):481–6. https://doi.org/10.1097/00006123-199803000-00008; discussion 7–9.

    Article  CAS  PubMed  Google Scholar 

  22. Stefani MA, Porter PJ, terBrugge KG, Montanera W, Willinsky RA, Wallace MC. Angioarchitectural factors present in brain arteriovenous malformations associated with hemorrhagic presentation. Stroke. 2002;33(4):920–4. https://doi.org/10.1161/01.str.0000014582.03429.f7.

    Article  PubMed  Google Scholar 

  23. al-Rodhan NR, Sundt TM Jr, Piepgras DG, Nichols DA, Rüfenacht D, Stevens LN. Occlusive hyperemia: a theory for the hemodynamic complications following resection of intracerebral arteriovenous malformations. J Neurosurg. 1993;78(2):167–75. https://doi.org/10.3171/jns.1993.78.2.0167.

    Article  CAS  PubMed  Google Scholar 

  24. Yaşargil M. Microneurosurgery: AVM of the brain: clinical considerations, general and special operative techniques, surgical results, nonoperated cases, cavernous and venous angiomas, neuroanesthesia. Stuttgart: Thieme; 1988.

    Google Scholar 

  25. Mahalick DM, Ruff RM, Heary RF, U HS. Preoperative versus postoperative neuropsychological sequelae of arteriovenous malformations. Neurosurgery. 1993;33(4):563–70. https://doi.org/10.1227/00006123-199310000-00003; discussion 70–1.

    Article  CAS  PubMed  Google Scholar 

  26. Spetzler RF, Wilson CB, Weinstein P, Mehdorn M, Townsend J, Telles D. Normal perfusion pressure breakthrough theory. Clin Neurosurg. 1978;25:651–72. https://doi.org/10.1093/neurosurgery/25.cn_suppl_1.651.

    Article  CAS  PubMed  Google Scholar 

  27. Moftakhar P, Hauptman JS, Malkasian D, Martin NA. Cerebral arteriovenous malformations. Part 2: physiology. Neurosurg Focus. 2009;26(5):E11. https://doi.org/10.3171/2009.2.Focus09317.

    Article  PubMed  Google Scholar 

  28. Stapf C, Labovitz DL, Sciacca RR, Mast H, Mohr JP, Sacco RL. Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. Cerebrovasc Dis. 2002;13(1):43–6. https://doi.org/10.1159/000047745.

    Article  PubMed  Google Scholar 

  29. Stapf C, Mast H, Sciacca RR, Berenstein A, Nelson PK, Gobin YP, et al. The New York Islands AVM study: design, study progress, and initial results. Stroke. 2003;34(5):e29–33. https://doi.org/10.1161/01.Str.0000068784.36838.19.

    Article  CAS  PubMed  Google Scholar 

  30. Al-Shahi R, Bhattacharya JJ, Currie DG, Papanastassiou V, Ritchie V, Roberts RC, et al. Prospective, population-based detection of intracranial vascular malformations in adults: the Scottish Intracranial Vascular Malformation Study (SIVMS). Stroke. 2003;34(5):1163–9. https://doi.org/10.1161/01.Str.0000069018.90456.C9.

    Article  PubMed  Google Scholar 

  31. Al-Shahi R. A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults. Brain. 2001;124(10):1900–26. https://doi.org/10.1093/brain/124.10.1900.

    Article  CAS  PubMed  Google Scholar 

  32. ApSimon HT, Reef H, Phadke RV, Popovic EA. A population-based study of brain arteriovenous malformation: long-term treatment outcomes. Stroke. 2002;33(12):2794–800. https://doi.org/10.1161/01.str.0000043674.99741.9b.

    Article  CAS  PubMed  Google Scholar 

  33. Tong X, Wu J, Lin F, Cao Y, Zhao Y, Ning B, et al. The effect of age, sex, and lesion location on initial presentation in patients with brain arteriovenous malformations. World Neurosurg. 2016;87:598–606. https://doi.org/10.1016/j.wneu.2015.10.060.

    Article  PubMed  Google Scholar 

  34. Petridis AK, Fischer I, Cornelius JF, Kamp MA, Ringel F, Tortora A, et al. Demographic distribution of hospital admissions for brain arteriovenous malformations in Germany—estimation of the natural course with the big-data approach. Acta Neurochir. 2016;158(4):791–6. https://doi.org/10.1007/s00701-016-2727-2.

    Article  PubMed  Google Scholar 

  35. Abecassis IJ, Xu DS, Batjer HH, Bendok BR. Natural history of brain arteriovenous malformations: a systematic review. Neurosurg Focus. 2014;37(3):E7. https://doi.org/10.3171/2014.6.Focus14250.

    Article  PubMed  Google Scholar 

  36. Brown RD Jr, Wiebers DO, Torner JC, O’Fallon WM. Frequency of intracranial hemorrhage as a presenting symptom and subtype analysis: a population-based study of intracranial vascular malformations in Olmsted Country, Minnesota. J Neurosurg. 1996;85(1):29–32. https://doi.org/10.3171/jns.1996.85.1.0029.

    Article  PubMed  Google Scholar 

  37. Hillman J. Population-based analysis of arteriovenous malformation treatment. J Neurosurg. 2001;95(4):633–7. https://doi.org/10.3171/jns.2001.95.4.0633.

    Article  CAS  PubMed  Google Scholar 

  38. Hoh BL, Chapman PH, Loeffler JS, Carter BS, Ogilvy CS. Results of multimodality treatment for 141 patients with brain arteriovenous malformations and seizures: factors associated with seizure incidence and seizure outcomes. Neurosurgery. 2002;51(2):303–9; discussion 9–11.

    Article  PubMed  Google Scholar 

  39. Garcin B, Houdart E, Porcher R, Manchon E, Saint-Maurice JP, Bresson D, et al. Epileptic seizures at initial presentation in patients with brain arteriovenous malformation. Neurology. 2012;78(9):626–31. https://doi.org/10.1212/WNL.0b013e3182494d40.

    Article  CAS  PubMed  Google Scholar 

  40. Ruan D, Yu XB, Shrestha S, Wang L, Chen G. The role of hemosiderin excision in seizure outcome in cerebral cavernous malformation surgery: a systematic review and meta-analysis. PLoS One. 2015;10(8):e0136619. https://doi.org/10.1371/journal.pone.0136619.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Choi JH, Mast H, Hartmann A, Marshall RS, Pile-Spellman J, Mohr JP, et al. Clinical and morphological determinants of focal neurological deficits in patients with unruptured brain arteriovenous malformation. J Neurol Sci. 2009;287(1–2):126–30. https://doi.org/10.1016/j.jns.2009.08.011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Lv X, Li Y, Yang X, Jiang C, Wu Z. Characteristics of brain arteriovenous malformations in patients presenting with nonhemorrhagic neurologic deficits. World Neurosurg. 2013;79(3–4):484–8. https://doi.org/10.1016/j.wneu.2012.04.006.

    Article  PubMed  Google Scholar 

  43. Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986;65(4):476–83. https://doi.org/10.3171/jns.1986.65.4.0476.

    Article  CAS  PubMed  Google Scholar 

  44. Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, et al. Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery. 2015;76(1):25–31. https://doi.org/10.1227/neu.0000000000000556; discussion 2; quiz 2–3.

    Article  PubMed  Google Scholar 

  45. Karlsson B, Lindquist C, Steiner L. Prediction of obliteration after gamma knife surgery for cerebral arteriovenous malformations. Neurosurgery. 1997;40(3):425–30. https://doi.org/10.1097/00006123-199703000-00001; discussion 30–1.

    Article  CAS  PubMed  Google Scholar 

  46. Schwartz M, Sixel K, Young C, Kemeny A, Forster D, Walton L, et al. Prediction of obliteration of arteriovenous malformations after radiosurgery: the obliteration prediction index. Can J Neurol Sci. 1997;24(2):106–9. https://doi.org/10.1017/S0317167100021417.

    Article  CAS  PubMed  Google Scholar 

  47. Pollock BE, Flickinger JC. Modification of the radiosurgery-based arteriovenous malformation grading system. Neurosurgery. 2008;63(2):239–43. https://doi.org/10.1227/01.Neu.0000315861.24920.92; discussion 43.

    Article  PubMed  Google Scholar 

  48. Dumont TM, Kan P, Snyder KV, Hopkins LN, Siddiqui AH, Levy EI. A proposed grading system for endovascular treatment of cerebral arteriovenous malformations: Buffalo score. Surg Neurol Int. 2015;6:3. https://doi.org/10.4103/2152-7806.148847.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Mossa-Basha M, Chen J, Gandhi D. Imaging of cerebral arteriovenous malformations and dural arteriovenous fistulas. Neurosurg Clin N Am. 2012;23(1):27–42. https://doi.org/10.1016/j.nec.2011.09.007.

    Article  PubMed  Google Scholar 

  50. Bérubé J, McLaughlin N, Bourgouin P, Beaudoin G, Bojanowski MW. Diffusion tensor imaging analysis of long association bundles in the presence of an arteriovenous malformation. J Neurosurg. 2007;107(3):509–14. https://doi.org/10.3171/JNS-07/09/0509.

    Article  PubMed  Google Scholar 

  51. Atlas SW, Mark AS, Fram EK, Grossman RI. Vascular intracranial lesions: applications of gradient-echo MR imaging. Radiology. 1988;169(2):455–61. https://doi.org/10.1148/radiology.169.2.3174993.

    Article  CAS  PubMed  Google Scholar 

  52. Jagadeesan BD, Delgado Almandoz JE, Moran CJ, Benzinger TLS. Accuracy of susceptibility-weighted imaging for the detection of arteriovenous shunting in vascular malformations of the brain. Stroke. 2011;42(1):87–92. https://doi.org/10.1161/strokeaha.110.584862.

    Article  PubMed  Google Scholar 

  53. Guo WY, Wu YT, Wu HM, Chung WY, Kao YH, Yeh TC, et al. Toward normal perfusion after radiosurgery: perfusion MR imaging with independent component analysis of brain arteriovenous malformations. Am J Neuroradiol. 2004;25(10):1636–44.

    PubMed  PubMed Central  Google Scholar 

  54. Machet A, Portefaix C, Kadziolka K, Robin G, Lanoix O, Pierot L. Brain arteriovenous malformation diagnosis: value of time-resolved contrast-enhanced MR angiography at 3.0T compared to DSA. Neuroradiology. 2012;54(10):1099–108. https://doi.org/10.1007/s00234-012-1024-x.

    Article  CAS  PubMed  Google Scholar 

  55. Togao O, Obara M, Helle M, Yamashita K, Kikuchi K, Momosaka D, et al. Vessel-selective 4D-MR angiography using super-selective pseudo-continuous arterial spin labeling may be a useful tool for assessing brain AVM hemodynamics. Eur Radiol. 2020;30(12):6452–63. https://doi.org/10.1007/s00330-020-07057-4.

    Article  PubMed  Google Scholar 

  56. Forster DM, Steiner L, Håkanson S. Arteriovenous malformations of the brain. A long-term clinical study. J Neurosurg. 1972;37(5):562–70. https://doi.org/10.3171/jns.1972.37.5.0562.

    Article  CAS  PubMed  Google Scholar 

  57. Ondra SL, Troupp H, George ED, Schwab K. The natural history of symptomatic arteriovenous malformations of the brain: a 24-year follow-up assessment. J Neurosurg. 1990;73(3):387–91. https://doi.org/10.3171/jns.1990.73.3.0387.

    Article  CAS  PubMed  Google Scholar 

  58. Ko NU, Johnston SC, Young WL, Singh V, Klatsky AL. Distinguishing intracerebral hemorrhages caused by arteriovenous malformations. Cerebrovasc Dis. 2003;15(3):206–9. https://doi.org/10.1159/000068829.

    Article  CAS  PubMed  Google Scholar 

  59. Fullerton HJ, Achrol AS, Johnston SC, McCulloch CE, Higashida RT, Lawton MT, et al. Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke. 2005;36(10):2099–104. https://doi.org/10.1161/01.STR.0000181746.77149.2b.

    Article  PubMed  Google Scholar 

  60. Meyer-Heim AD, Boltshauser E. Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain Dev. 2003;25(6):416–21. https://doi.org/10.1016/s0387-7604(03)00029-9.

    Article  PubMed  Google Scholar 

  61. van Beijnum J, Lovelock CE, Cordonnier C, Rothwell PM, Klijn CJ, Al-Shahi Salman R. Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies. Brain. 2009;132(Pt 2):537–43. https://doi.org/10.1093/brain/awn318.

    Article  PubMed  Google Scholar 

  62. Da Costa L, Wallace MC, Ter Brugge KG, O’Kelly C, Willinsky RA, Tymianski M. The natural history and predictive features of hemorrhage from brain arteriovenous malformations. Stroke. 2009;40(1):100–5. https://doi.org/10.1161/strokeaha.108.524678.

    Article  PubMed  Google Scholar 

  63. Kader A, Young WL, Pile-Spellman J, Mast H, Sciacca RR, Mohr JP, et al. The influence of hemodynamic and anatomic factors on hemorrhage from cerebral arteriovenous malformations. Neurosurgery. 1994;34(5):801–7. https://doi.org/10.1227/00006123-199405000-00003; discussion 7–8.

    Article  CAS  PubMed  Google Scholar 

  64. Duong DH, Young WL, Vang MC, Sciacca RR, Mast H, Koennecke H-C, et al. Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations. Stroke. 1998;29(6):1167–76. https://doi.org/10.1161/01.str.29.6.1167.

    Article  CAS  PubMed  Google Scholar 

  65. Stefani MA, Porter PJ, Terbrugge KG, Montanera W, Willinsky RA, Wallace MC. Large and deep brain arteriovenous malformations are associated with risk of future hemorrhage. Stroke. 2002;33(5):1220–4. https://doi.org/10.1161/01.str.0000013738.53113.33.

    Article  PubMed  Google Scholar 

  66. Ding D, Starke RM, Quigg M, Yen CP, Przybylowski CJ, Dodson BK, et al. Cerebral arteriovenous malformations and epilepsy, part 1: predictors of seizure presentation. World Neurosurg. 2015;84(3):645–52. https://doi.org/10.1016/j.wneu.2015.02.039.

    Article  PubMed  Google Scholar 

  67. Englot DJ, Young WL, Han SJ, McCulloch CE, Chang EF, Lawton MT. Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patients. Neurosurgery. 2012;71(3):572–80. https://doi.org/10.1227/neu.0b013e31825ea3ba.

    Article  PubMed  Google Scholar 

  68. Turjman F, Massoud TF, Sayre JW, Viñuela F, Guglielmi G, Duckwiler G. Epilepsy associated with cerebral arteriovenous malformations: a multivariate analysis of angioarchitectural characteristics. Am J Neuroradiol. 1995;16(2):345–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Crawford PM, West CR, Shaw MD, Chadwick DW. Cerebral arteriovenous malformations and epilepsy: factors in the development of epilepsy. Epilepsia. 1986;27(3):270–5. https://doi.org/10.1111/j.1528-1157.1986.tb03539.x.

    Article  CAS  PubMed  Google Scholar 

  70. Spetzler RF, Ponce FA. A 3-tier classification of cerebral arteriovenous malformations. Clinical article. J Neurosurg. 2011;114(3):842–9. https://doi.org/10.3171/2010.8.Jns10663.

    Article  PubMed  Google Scholar 

  71. Schramm J, Schaller K, Esche J, Boström A. Microsurgery for cerebral arteriovenous malformations: subgroup outcomes in a consecutive series of 288 cases. J Neurosurg. 2017;126(4):1056–63. https://doi.org/10.3171/2016.4.jns153017.

    Article  PubMed  Google Scholar 

  72. Han PP, Ponce FA, Spetzler RF. Intention-to-treat analysis of Spetzler-Martin grades IV and V arteriovenous malformations: natural history and treatment paradigm. J Neurosurg. 2003;98(1):3–7. https://doi.org/10.3171/jns.2003.98.1.0003.

    Article  PubMed  Google Scholar 

  73. Ding D, Starke RM, Kano H, Mathieu D, Huang PP, Feliciano C, et al. International multicenter cohort study of pediatric brain arteriovenous malformations. Part 1: predictors of hemorrhagic presentation. J Neurosurg Pediatr. 2017;19(2):127–35. https://doi.org/10.3171/2016.9.peds16283.

    Article  PubMed  Google Scholar 

  74. Luessenhop AJ, Spence WT. Artificial embolization of cerebral arteries. Report of use in a case of arteriovenous malformation. J Am Med Assoc. 1960;172:1153–5. https://doi.org/10.1001/jama.1960.63020110001009.

    Article  CAS  PubMed  Google Scholar 

  75. Newton TH, Cronqvist S. Involvement of dural arteries in intracranial arteriovenous malformations. Radiology. 1969;93(5):1071–8. https://doi.org/10.1148/93.5.1071.

    Article  CAS  PubMed  Google Scholar 

  76. Jin H, Qiu H, Chen C, Ge H, Li Y, He H. Embolization of feeding arteries and symptom alleviation of mixed dural-pial arteriovenous malformations. Chin Neurosurg J. 2018;4:5. https://doi.org/10.1186/s41016-018-0111-1.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Serbinenko FA. Balloon catheterization and occlusion of major cerebral vessels. J Neurosurg. 1974;41(2):125–45. https://doi.org/10.3171/jns.1974.41.2.0125.

    Article  CAS  PubMed  Google Scholar 

  78. Kerber C. Balloon catheter with a calibrated leak. A new system for superselective angiography and occlusive catheter therapy. Radiology. 1976;120(3):547–50. https://doi.org/10.1148/120.3.547.

    Article  CAS  PubMed  Google Scholar 

  79. Bruno CA, Meyers PM. Endovascular management of arteriovenous malformations of the brain. Interv Neurol. 2012;1(3–4):109–23. https://doi.org/10.1159/000346927.

    Article  Google Scholar 

  80. Miyamoto S, Hashimoto N, Nagata I, Nozaki K, Morimoto M, Taki W, et al. Posttreatment sequelae of palliatively treated cerebral arteriovenous malformations. Neurosurgery. 2000;46(3):589–94. https://doi.org/10.1097/00006123-200003000-00013; discussion 94–5.

    Article  CAS  PubMed  Google Scholar 

  81. Lv X, Wu Z, Li Y, Yang X, Jiang C. Hemorrhage risk after partial endovascular NBCA and ONYX embolization for brain arteriovenous malformation. Neurol Res. 2012;34(6):552–6. https://doi.org/10.1179/1743132812y.0000000044.

    Article  CAS  PubMed  Google Scholar 

  82. Steiner L, Leksell L, Greitz T, Forster DM, Backlund EO. Stereotaxic radiosurgery for cerebral arteriovenous malformations. Report of a case. Acta Chir Scand. 1972;138(5):459–64.

    CAS  PubMed  Google Scholar 

  83. Kano H, Kondziolka D, Flickinger JC, Yang HC, Flannery TJ, Niranjan A, et al. Stereotactic radiosurgery for arteriovenous malformations, part 4: management of basal ganglia and thalamus arteriovenous malformations. J Neurosurg. 2012;116(1):33–43. https://doi.org/10.3171/2011.9.Jns11175.

    Article  PubMed  Google Scholar 

  84. Kano H, Lunsford LD, Flickinger JC, Yang HC, Flannery TJ, Awan NR, et al. Stereotactic radiosurgery for arteriovenous malformations, part 1: management of Spetzler-Martin Grade I and II arteriovenous malformations. J Neurosurg. 2012;116(1):11–20. https://doi.org/10.3171/2011.9.Jns101740.

    Article  PubMed  Google Scholar 

  85. Koltz MT, Polifka AJ, Saltos A, Slawson RG, Kwok Y, Aldrich EF, et al. Long-term outcome of gamma knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classification. J Neurosurg. 2013;118(1):74–83. https://doi.org/10.3171/2012.9.Jns112329.

    Article  PubMed  Google Scholar 

  86. Karlsson B, Jokura H, Yamamoto M, Söderman M, Lax I. Is repeated radiosurgery an alternative to staged radiosurgery for very large brain arteriovenous malformations? J Neurosurg. 2007;107(4):740–4. https://doi.org/10.3171/jns-07/10/0740.

    Article  PubMed  Google Scholar 

  87. Sirin S, Kondziolka D, Niranjan A, Flickinger JC, Maitz AH, Lunsford LD. Prospective staged volume radiosurgery for large arteriovenous malformations: indications and outcomes in otherwise untreatable patients. Neurosurgery. 2008;62(Suppl 2):744–54. https://doi.org/10.1227/01.neu.0000316278.14748.87.

    Article  PubMed  Google Scholar 

  88. Szeifert GT, Levivier M, Lorenzoni J, Nyáry I, Major O, Kemeny AA. Morphological observations in brain arteriovenous malformations after gamma knife radiosurgery. Prog Neurol Surg. 2013;27:119–29. https://doi.org/10.1159/000341772.

    Article  PubMed  Google Scholar 

  89. Simon AB, Hurt B, Karunamuni R, Kim GY, Moiseenko V, Olson S, et al. Automated segmentation of multiparametric magnetic resonance images for cerebral AVM radiosurgery planning: a deep learning approach. Sci Rep. 2022;12(1):786. https://doi.org/10.1038/s41598-021-04466-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Starke RM, Yen CP, Ding D, Sheehan JP. A practical grading scale for predicting outcome after radiosurgery for arteriovenous malformations: analysis of 1012 treated patients. J Neurosurg. 2013;119(4):981–7. https://doi.org/10.3171/2013.5.Jns1311.

    Article  PubMed  Google Scholar 

  91. Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014;383(9917):614–21. https://doi.org/10.1016/s0140-6736(13)62302-8.

    Article  CAS  PubMed  Google Scholar 

  92. Teo M, St George J, Lawton MT. Time for BARBADOS after ARUBA trial. Br J Neurosurg. 2015;29(5):635–6. https://doi.org/10.3109/02688697.2015.1096909.

    Article  PubMed  Google Scholar 

  93. Darsaut TE, Magro E, Gentric JC, Batista AL, Chaalala C, Roberge D, et al. Treatment of brain AVMs (TOBAS): study protocol for a pragmatic randomized controlled trial. Trials. 2015;16:497. https://doi.org/10.1186/s13063-015-1019-0.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Davidson AS, Morgan MK. How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations. Neurosurgery. 2010;66(3):498–504. https://doi.org/10.1227/01.Neu.0000365518.47684.98; discussion 5.

    Article  PubMed  Google Scholar 

  95. Lak AM, Cerecedo-Lopez CD, Cha J, Aziz-Sultan MA, Frerichs KU, Gormley WB, et al. Seizure outcomes after interventional treatment in cerebral arteriovenous malformation-associated epilepsy: a systematic review and meta-analysis. World Neurosurg. 2022;160:e9–22. https://doi.org/10.1016/j.wneu.2021.09.063.

    Article  PubMed  Google Scholar 

  96. Mamaril-Davis JC, Aguilar-Salinas P, Avila MJ, Nakaji P, Bina RW. Complete seizure-free rates following interventional treatment of intracranial arteriovenous malformations: a systematic review and meta-analysis. Neurosurg Rev. 2022;45(2):1313–26. https://doi.org/10.1007/s10143-021-01724-w.

    Article  PubMed  Google Scholar 

  97. Brosnan C, Amoo M, Javadpour M. Preoperative embolisation of brain arteriovenous malformations: a systematic review and meta-analysis. Neurosurg Rev. 2022;45(3):2051–63. https://doi.org/10.1007/s10143-022-01766-8.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Taylor CL, Dutton K, Rappard G, Pride GL, Replogle R, Purdy PD, et al. Complications of preoperative embolization of cerebral arteriovenous malformations. J Neurosurg. 2004;100(5):810–2. https://doi.org/10.3171/jns.2004.100.5.0810.

    Article  PubMed  Google Scholar 

  99. Saatci I, Geyik S, Yavuz K, Cekirge HS. Endovascular treatment of brain arteriovenous malformations with prolonged intranidal Onyx injection technique: long-term results in 350 consecutive patients with completed endovascular treatment course. J Neurosurg. 2011;115(1):78–88. https://doi.org/10.3171/2011.2.Jns09830.

    Article  PubMed  Google Scholar 

  100. Sanchez-Mejia RO, McDermott MW, Tan J, Kim H, Young WL, Lawton MT. Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity. Neurosurgery. 2009;64(2):231–8. https://doi.org/10.1227/01.Neu.0000338068.44060.Ea; discussion 8–40.

    Article  PubMed  Google Scholar 

  101. Zabel-du Bois A, Milker-Zabel S, Huber P, Schlegel W, Debus J. Risk of hemorrhage and obliteration rates of LINAC-based radiosurgery for cerebral arteriovenous malformations treated after prior partial embolization. Int J Radiat Oncol Biol Phys. 2007;68(4):999–1003. https://doi.org/10.1016/j.ijrobp.2007.01.027.

    Article  PubMed  Google Scholar 

  102. Chye C-L, Wang K-W, Chen H-J, Yeh S-A, Tang JT, Liang C-L. Haemorrhage rates of ruptured and unruptured brain arteriovenous malformation after radiosurgery: a nationwide population-based cohort study. BMJ Open. 2020;10(10):e036606. https://doi.org/10.1136/bmjopen-2019-036606.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Herbert C, Moiseenko V, McKenzie M, Redekop G, Hsu F, Gete E, et al. Factors predictive of symptomatic radiation injury after linear accelerator-based stereotactic radiosurgery for intracerebral arteriovenous malformations. Int J Radiat Oncol Biol Phys. 2012;83(3):872–7. https://doi.org/10.1016/j.ijrobp.2011.08.019.

    Article  PubMed  Google Scholar 

  104. Kaido T, Hoshida T, Uranishi R, Akita N, Kotani A, Nishi N, et al. Radiosurgery-induced brain tumor. Case report. J Neurosurg. 2001;95(4):710–3. https://doi.org/10.3171/jns.2001.95.4.0710.

    Article  CAS  PubMed  Google Scholar 

  105. Husain AM, Mendez M, Friedman AH. Intractable epilepsy following radiosurgery for arteriovenous malformation. J Neurosurg. 2001;95(5):888–92. https://doi.org/10.3171/jns.2001.95.5.0888.

    Article  CAS  PubMed  Google Scholar 

  106. Yeo SS, Jang SH. Delayed neural degeneration following gamma knife radiosurgery in a patient with an arteriovenous malformation: a diffusion tensor imaging study. NeuroRehabilitation. 2012;31(2):131–5. https://doi.org/10.3233/nre-2012-0780.

    Article  PubMed  Google Scholar 

  107. Starke RM, Ding D, Kano H, Mathieu D, Huang PP, Feliciano C, et al. International multicenter cohort study of pediatric brain arteriovenous malformations. Part 2: outcomes after stereotactic radiosurgery. J Neurosurg Pediatr. 2017;19(2):136–48. https://doi.org/10.3171/2016.9.peds16284.

    Article  PubMed  Google Scholar 

  108. Börcek A, Çeltikçi E, Aksoğan Y, Rousseau MJ. Clinical outcomes of stereotactic radiosurgery for cerebral arteriovenous malformations in pediatric patients: systematic review and meta-analysis. Neurosurgery. 2019;85(4):E629–40. https://doi.org/10.1093/neuros/nyz146.

    Article  PubMed  Google Scholar 

  109. Deruty R, Pelissou-Guyotat I, Amat D, Mottolese C, Bascoulergue Y, Turjman F, et al. Complications after multidisciplinary treatment of cerebral arteriovenous malformations. Acta Neurochir. 1996;138(2):119–31. https://doi.org/10.1007/bf01411350.

    Article  CAS  PubMed  Google Scholar 

  110. Pollock BE, Flickinger JC, Lunsford LD, Maitz A, Kondziolka D. Factors associated with successful arteriovenous malformation radiosurgery. Neurosurgery. 1998;42(6):1239–44. https://doi.org/10.1097/00006123-199806000-00020; discussion 44–7.

    Article  CAS  PubMed  Google Scholar 

  111. Gobin YP, Laurent A, Merienne L, Schlienger M, Aymard A, Houdart E, et al. Treatment of brain arteriovenous malformations by embolization and radiosurgery. J Neurosurg. 1996;85(1):19–28. https://doi.org/10.3171/jns.1996.85.1.0019.

    Article  CAS  PubMed  Google Scholar 

  112. Friedman WA, Bova FJ. Radiosurgery for arteriovenous malformations. Neurol Res. 2011;33(8):803–19. https://doi.org/10.1179/1743132811y.0000000043.

    Article  PubMed  Google Scholar 

  113. Andrade-Souza YM, Ramani M, Scora D, Tsao MN, terBrugge K, Schwartz ML. Embolization before radiosurgery reduces the obliteration rate of arteriovenous malformations. Neurosurgery. 2007;60(3):443–51. https://doi.org/10.1227/01.Neu.0000255347.25959.D0; discussion 51–2.

    Article  PubMed  Google Scholar 

  114. Van Beijnum J, Van Der Worp HB, Buis DR, Salman RA-S, Kappelle LJ, Rinkel GJE, et al. Treatment of brain arteriovenous malformations. JAMA. 2011;306(18):2011. https://doi.org/10.1001/jama.2011.1632.

    Article  PubMed  Google Scholar 

  115. Chen CJ, Ding D, Lee CC, Kearns KN, Pomeraniec IJ, Cifarelli CP, et al. Embolization of brain arteriovenous malformations with versus without Onyx before stereotactic radiosurgery. Neurosurgery. 2021;88(2):366–74. https://doi.org/10.1093/neuros/nyaa370.

    Article  PubMed  Google Scholar 

  116. Akakin A, Ozkan A, Akgun E, Koc DY, Konya D, Pamir MN, et al. Endovascular treatment increases but gamma knife radiosurgery decreases angiogenic activity of arteriovenous malformations: an in vivo experimental study using a rat cornea model. Neurosurgery. 2010;66(1):121–9. https://doi.org/10.1227/01.Neu.0000363154.88768.34; discussion 9–30.

    Article  PubMed  Google Scholar 

  117. Pollock BE, Kondziolka D, Lunsford LD, Bissonette D, Flickinger JC. Repeat stereotactic radiosurgery of arteriovenous malformations: factors associated with incomplete obliteration. Neurosurgery. 1996;38(2):318–24. https://doi.org/10.1097/00006123-199602000-00016.

    Article  CAS  PubMed  Google Scholar 

  118. Jiang Z, Zhang X, Wan X, Wei M, Liu Y, Ding C, et al. Efficacy and safety of combined endovascular embolization and stereotactic radiosurgery for patients with intracranial arteriovenous malformations: a systematic review and meta-analysis. Biomed Res Int. 2021;2021:6686167. https://doi.org/10.1155/2021/6686167.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Zhu D, Li Z, Zhang Y, Fang Y, Li Q, Zhao R, et al. Gamma knife surgery with and without embolization for cerebral arteriovenous malformations: a systematic review and meta-analysis. J Clin Neurosci. 2018;56:67–73. https://doi.org/10.1016/j.jocn.2018.07.008.

    Article  PubMed  Google Scholar 

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Beneš, V., Bubeníková, A., Skalický, P., Bradáč, O. (2024). Treatment of Brain Arteriovenous Malformations. In: Di Rocco, C. (eds) Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-031-42398-7_8

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