Abstract
Vestibular neuritis is an isolated unilateral peripheral vestibulopathy that causes a rapid-onset spinning vertigo. Vestibular neuritis often develops following a viral illness and is associated with inflammation and demyelination of the vestibular nerve. Patients exhibit spontaneous nystagmus, a positive head impulse test, and imbalance without focal neurological deficits. Vestibular suppressants (meclizine, benzodiazepines) are used to treat acute symptoms of this disorder. Treatment with corticosteroids and vestibular exercises should begin early after onset of symptoms to accelerate the return to normal activities of daily living (ADLs). The symptoms of acute vestibular neuritis typically resolve over the course of days to weeks, but a permanent unilateral vestibular impairment can persist. In the setting of incomplete central compensation, patients can experience residual symptoms over months to years.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Strupp M, Mandala M, Lopez-Escamez JA. Peripheral vestibular disorders: an update. Curr Opin Neurol. 2019;32(1):165–73. https://doi.org/10.1097/WCO.0000000000000649.
Neuhauser HK. The epidemiology of dizziness and vertigo. Handb Clin Neurol. 2016;137:67–82. https://doi.org/10.1016/B978-0-444-63437-5.00005-4.
Muelleman T, Shew M, Subbarayan R, Shum A, Sykes K, Staecker H, et al. Epidemiology of dizzy patient population in a neurotology clinic and predictors of peripheral etiology. Otol Neurotol. 2017;38(6):870–5. https://doi.org/10.1097/MAO.0000000000001429.
Greco A, Macri GF, Gallo A, Fusconi M, De Virgilio A, Pagliuca G, et al. Is vestibular neuritis an immune related vestibular neuropathy inducing vertigo? J Immunol Res. 2014;2014:459048. https://doi.org/10.1155/2014/459048.
Bartual-Pastor J. Vestibular neuritis: etiopathogenesis. Rev Laryngol Otol Rhinol (Bord). 2005;126(4):279–81.
Strupp M, Magnusson M. Acute unilateral vestibulopathy. Neurol Clin. 2015;33(3):669–85, x. https://doi.org/10.1016/j.ncl.2015.04.012.
Baloh RW. Clinical practice. Vestibular neuritis. N Engl J Med. 2003;348(11):1027–32. https://doi.org/10.1056/NEJMcp021154.
Matsuo T. Vestibular neuronitis—serum and CSF virus antibody titer. Auris Nasus Larynx. 1986;13(1):11–34. https://doi.org/10.1016/s0385-8146(86)80020-7.
Fishman JM. Corticosteroids effective in idiopathic facial nerve palsy (Bell’s palsy) but not necessarily in idiopathic acute vestibular dysfunction (vestibular neuritis). Laryngoscope. 2011;121(11):2494–5. https://doi.org/10.1002/lary.22327.
Rujescu D, Hartmann AM, Giegling I, Konte B, Herrling M, Himmelein S, et al. Genome-wide association study in vestibular neuritis: involvement of the host factor for HSV-1 replication. Front Neurol. 2018;9:591. https://doi.org/10.3389/fneur.2018.00591.
Arbusow V, Schulz P, Strupp M, Dieterich M, von Reinhardstoettner A, Rauch E, et al. Distribution of herpes simplex virus type 1 in human geniculate and vestibular ganglia: implications for vestibular neuritis. Ann Neurol. 1999;46(3):416–9. https://doi.org/10.1002/1531-8249(199909)46:3<416::aid-ana20>3.0.co;2-w.
Arbusow V, Derfuss T, Held K, Himmelein S, Strupp M, Gurkov R, et al. Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells. J Med Virol. 2010;82(11):1917–20. https://doi.org/10.1002/jmv.21904.
Roehm PC, Camarena V, Nayak S, Gardner JB, Wilson A, Mohr I, et al. Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation. Laryngoscope. 2011;121(10):2268–75. https://doi.org/10.1002/lary.22035.
Hotson JR, Baloh RW. Acute vestibular syndrome. N Engl J Med. 1998;339(10):680–5. https://doi.org/10.1056/NEJM199809033391007.
Bumm P, Schlimok G. T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell’s palsy, hearing loss, neuronitis vestibularis, and Meniere’s disease. Eur Arch Otorhinolaryngol. 1994:S447–8. https://doi.org/10.1007/978-3-642-85090-5_178.
Bumm P, Muller EC, Grimm-Muller U, Schlimok G. [T-lymphocyte subpopulation and HLA-DR antigens in hearing loss of vestibular neuropathy, Meniere’s diseases and Bell’s palsy]. Laryngorhinootologie. 1991;70(5):260–6. https://doi.org/10.1055/s-2007-998033.
Kassner SS, Schottler S, Bonaterra GA, Stern-Straeter J, Hormann K, Kinscherf R, et al. Proinflammatory activation of peripheral blood mononuclear cells in patients with vestibular neuritis. Audiol Neurootol. 2011;16(4):242–7. https://doi.org/10.1159/000320839.
Bonaterra GA, Hildebrandt W, Bodens A, Sauer R, Dugi KA, Deigner HP, et al. Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects. Free Radic Biol Med. 2005;38(2):235–42. https://doi.org/10.1016/j.freeradbiomed.2004.10.021.
Bonaterra GA, Hildebrandt W, Bodens A, Sauer R, Dugi KA, Deigner HP, et al. Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males. J Mol Med (Berl). 2007;85(2):181–90. https://doi.org/10.1007/s00109-006-0117-6.
Oron Y, Shemesh S, Shushan S, Cinamon U, Goldfarb A, Dabby R, et al. Cardiovascular risk factors among patients with vestibular neuritis. Ann Otol Rhinol Laryngol. 2017;126(8):597–601. https://doi.org/10.1177/0003489417718846.
Fetter M, Dichgans J. Vestibular neuritis spares the inferior division of the vestibular nerve. Brain. 1996;119(Pt 3):755–63. https://doi.org/10.1093/brain/119.3.755.
Silvoniemi P. Vestibular neuronitis. An otoneurological evaluation. Acta Otolaryngol Suppl. 1988;453:1–72. https://doi.org/10.3109/00016488809098974.
Gianoli G, Goebel J, Mowry S, Poomipannit P. Anatomic differences in the lateral vestibular nerve channels and their implications in vestibular neuritis. Otol Neurotol. 2005;26(3):489–94. https://doi.org/10.1097/01.mao.0000169787.99835.9f.
Jeong SH, Kim HJ, Kim JS. Vestibular neuritis. Semin Neurol. 2013;33(3):185–94. https://doi.org/10.1055/s-0033-1354598.
Aw ST, Fetter M, Cremer PD, Karlberg M, Halmagyi GM. Individual semicircular canal function in superior and inferior vestibular neuritis. Neurology. 2001;57(5):768–74. https://doi.org/10.1212/wnl.57.5.768.
Norrving B, Magnusson M, Holtas S. Isolated acute vertigo in the elderly; vestibular or vascular disease? Acta Neurol Scand. 1995;91(1):43–8. https://doi.org/10.1111/j.1600-0404.1995.tb05841.x.
Kattah JC. Use of HINTS in the acute vestibular syndrome. An overview. Stroke Vasc Neurol. 2018;3(4):190–6. https://doi.org/10.1136/svn-2018-000160.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009;40(11):3504–10. https://doi.org/10.1161/STROKEAHA.109.551234.
Halmagyi GM, Chen L, MacDougall HG, Weber KP, McGarvie LA, Curthoys IS. The video head impulse test. Front Neurol. 2017;8:258. https://doi.org/10.3389/fneur.2017.00258.
Strupp M, Arbusow V, Maag KP, Gall C, Brandt T. Vestibular exercises improve central vestibulospinal compensation after vestibular neuritis. Neurology. 1998;51(3):838–44. https://doi.org/10.1212/wnl.51.3.838.
Tokle G, Morkved S, Brathen G, Goplen FK, Salvesen O, Arnesen H, et al. Efficacy of vestibular rehabilitation following acute vestibular neuritis: a randomized controlled trial. Otol Neurotol. 2020;41(1):78–85. https://doi.org/10.1097/MAO.0000000000002443.
Bronstein AM, Dieterich M. Long-term clinical outcome in vestibular neuritis. Curr Opin Neurol. 2019;32(1):174–80. https://doi.org/10.1097/WCO.0000000000000652.
Cousins S, Kaski D, Cutfield N, Arshad Q, Ahmad H, Gresty MA, et al. Predictors of clinical recovery from vestibular neuritis: a prospective study. Ann Clin Transl Neurol. 2017;4(5):340–6. https://doi.org/10.1002/acn3.386.
Adamec I, Krbot Skoric M, Ozretic D, Habek M. Predictors of development of chronic vestibular insufficiency after vestibular neuritis. J Neurol Sci. 2014;347(1–2):224–8. https://doi.org/10.1016/j.jns.2014.10.001.
Batuecas-Caletrio A, Yanez-Gonzalez R, Sanchez-Blanco C, Perez PB, Gonzalez-Sanchez E, Sanchez LA, et al. Glucocorticoids improve acute dizziness symptoms following acute unilateral vestibulopathy. J Neurol. 2015;262(11):2578–82. https://doi.org/10.1007/s00415-015-7918-x.
Shupak A, Issa A, Golz A, Margalit K, Braverman I. Prednisone treatment for vestibular neuritis. Otol Neurotol. 2008;29(3):368–74. https://doi.org/10.1097/MAO.0b013e3181692804.
Goudakos JK, Markou KD, Psillas G, Vital V, Tsaligopoulos M. Corticosteroids and vestibular exercises in vestibular neuritis. Single-blind randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2014;140(5):434–40. https://doi.org/10.1001/jamaoto.2014.48.
Ismail EI, Morgan AE, Abdel Rahman AM. Corticosteroids versus vestibular rehabilitation in long-term outcomes in vestibular neuritis. J Vestib Res. 2018;28(5–6):417–24. https://doi.org/10.3233/VES-180645.
Cousins S, Cutfield NJ, Kaski D, Palla A, Seemungal BM, Golding JF, et al. Visual dependency and dizziness after vestibular neuritis. PLoS One. 2014;9(9):e105426. https://doi.org/10.1371/journal.pone.0105426.
Huppert D, Strupp M, Theil D, Glaser M, Brandt T. Low recurrence rate of vestibular neuritis: a long-term follow-up. Neurology. 2006;67(10):1870–1. https://doi.org/10.1212/01.wnl.0000244473.84246.76.
Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology. 1987;37(3):371–8. https://doi.org/10.1212/wnl.37.3.371.
Turk B, Akpinar M, Kaya KS, Korkut AY, Turgut S. Benign paroxysmal positional vertigo: comparison of idiopathic BPPV and BPPV secondary to vestibular neuritis. Ear Nose Throat J. 2019;100:145561319871234. https://doi.org/10.1177/0145561319871234.
Karlberg M, Halmagyi GM, Buttner U, Yavor RA. Sudden unilateral hearing loss with simultaneous ipsilateral posterior semicircular canal benign paroxysmal positional vertigo: a variant of vestibulo-cochlear neurolabyrinthitis? Arch Otolaryngol Head Neck Surg. 2000;126(8):1024–9. https://doi.org/10.1001/archotol.126.8.1024.
Mandala M, Santoro GP, Awrey J, Nuti D. Vestibular neuritis: recurrence and incidence of secondary benign paroxysmal positional vertigo. Acta Otolaryngol. 2010;130(5):565–7. https://doi.org/10.3109/00016480903311278.
Balatsouras DG, Koukoutsis G, Ganelis P, Economou NC, Moukos A, Aspris A, et al. Benign paroxysmal positional vertigo secondary to vestibular neuritis. Eur Arch Otorhinolaryngol. 2014;271(5):919–24. https://doi.org/10.1007/s00405-013-2484-2.
Godemann F, Schabowska A, Naetebusch B, Heinz A, Strohle A. The impact of cognitions on the development of panic and somatoform disorders: a prospective study in patients with vestibular neuritis. Psychol Med. 2006;36(1):99–108. https://doi.org/10.1017/S0033291705005921.
Godemann F, Schuller J, Uhlemann H, Budde A, Heinz A, Strohle A, et al. Psychodynamic vulnerability factors in the development of panic disorders—a prospective trial in patients after vestibular neuritis. Psychopathology. 2009;42(2):99–107. https://doi.org/10.1159/000203342.
Lee S, Kaylie DM. Balance (anatomy: vestibular nerve). In: Kountakis SE, editor. Encyclopedia of otolaryngology, head and neck surgery. Berlin: Springer; 2013. https://doi.org/10.1007/978-3-642-23499-6_577.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Lindemann, T.L., Roehm, P.C. (2023). Vestibular Neuritis. In: Crane, B.T., Lustig, L., de Souza, C. (eds) Disorders of the Vestibular System. Springer, Cham. https://doi.org/10.1007/978-3-031-40524-2_5
Download citation
DOI: https://doi.org/10.1007/978-3-031-40524-2_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-40523-5
Online ISBN: 978-3-031-40524-2
eBook Packages: MedicineMedicine (R0)