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Ectopic Pregnancy: Diagnosis and Complications

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Pathology of the Ovary, Fallopian Tube and Peritoneum

Part of the book series: Essentials of Diagnostic Gynecological Pathology ((EDGP))

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Abstract

The fallopian tube extends from the ovary to the corners of the uterus and plays a crucial role in reproduction. Many reactive and benign conditions may lead to the occlusion or narrowing of the fallopian tube, predisposing to ectopic pregnancy. Although tubal pregnancy accounts for over 95% of cases of ectopic pregnancy, primary (tubal) gestational trophoblastic disease is rare and is usually secondary to the lesion in the corpus.

The principal intent of this chapter is to discuss the pathology of ectopic pregnancy and describe trophoblastic tubal lesions as they can present clinically as ectopic pregnancy. The correct diagnosis and classification of the rare trophoblastic tubal disease are important. The morphological appearances and immunocytochemistry aiding the diagnosis and the changes in the current WHO classification of Gestational trophoblastic diseases (WHO Classification of Tumours Editorial Board. Female genital tumours. WHO Classification of tumour series. International Agency for Research on Cancer, Lyon, 309–322, 2020) will be highlighted.

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References

  1. Bouyer J, Coste J, Fernandez H, Pouly JL, Job-Spira N. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod. 2002;17(12):3224–30. PMID: 12456628. https://doi.org/10.1093/humrep/17.12.3224.

    Article  CAS  PubMed  Google Scholar 

  2. Rotas MA, Haberman S, Levgur M. Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol. 2006;107(6):1373–81. https://doi.org/10.1097/01.AOG.0000218690.24494.ce.

    Article  PubMed  Google Scholar 

  3. Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol. 2012;207(1):44.e1–13. Epub 2012 Apr 16. PMID: 22607667. https://doi.org/10.1016/j.ajog.2012.04.018.

    Article  PubMed  Google Scholar 

  4. Kochi K, Hidaka T, Yasoshima K, et al. Cervical pregnancy: a report of four cases. J Obstet Gynaecol Res. 2014;40:603–6.

    Article  PubMed  Google Scholar 

  5. Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015;1:15. PMID: 28620520; PMCID: PMC5424401. https://doi.org/10.1186/s40738-015-0008-z.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Aliyu LD, Ashimi AO. A multicentre study of advanced abdominal pregnancy: a review of six cases in low resource settings. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):33–8. Epub 2013 Jun 24. PMID: 23806448. https://doi.org/10.1016/j.ejogrb.2013.05.022.

    Article  CAS  PubMed  Google Scholar 

  7. Poole A, Haas D, Magann EF. Early abdominal ectopic pregnancies: a systematic review of the literature. Gynecol Obstet Invest. 2012;74(4):249–60. Epub 2012 Oct 25. PMID: 23108297. https://doi.org/10.1159/000342997.

    Article  PubMed  Google Scholar 

  8. Fylstra DL. Tubal pregnancy: a review of current diagnosis and treatment. Obstet Gynecol Surv. 1998;53(5):320–8.

    Article  CAS  PubMed  Google Scholar 

  9. Rajkhowa M, Glass MR, Rutherford AJ, et al. Trends in the incidence of ectopic pregnancy in England and Wales from 1966 to 1996. Br J Obstet Gynaecol. 2000;107(3):369–74.

    Article  CAS  Google Scholar 

  10. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L, Job-Spira N. Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol. 2003;157(3):185–94. PMID: 12543617. https://doi.org/10.1093/aje/kwf190.

    Article  PubMed  Google Scholar 

  11. Kutluay L, Vicdan K, Turan C, et al. Tubal histopathology in ectopic pregnancies. Eur J Obstet Gynecol Reprod Biol. 1994;57:91–4.

    Article  CAS  PubMed  Google Scholar 

  12. Green LK, Kott ML. Histopathologic findings in ectopic tubal pregnancy. Int J Gynecol Pathol. 1989;8:255–62.

    Article  CAS  PubMed  Google Scholar 

  13. Ankum WM, Mol BW, Van der Veen F, Bossuyt PM. Risk factors for ectopic pregnancy: a meta-analysis. Fertil Steril. 1996;65(6):1093–9. PMID: 8641479.

    Article  CAS  PubMed  Google Scholar 

  14. Garrett AM, Vukov LF. Risk factors for ectopic pregnancy in a rural population. Fam Med. 1996;28(2):111–3.

    CAS  PubMed  Google Scholar 

  15. Goldberg JM, Falcone T. Effect of diethylstilbestrol on reproductive function. Fertil Steril. 1999;72:1–7.

    Article  CAS  PubMed  Google Scholar 

  16. Castles A, Adams EK, Melvin CL, Kelsch C, Boulton ML. Effects of smoking during pregnancy. Five meta-analyses. Am J Prev Med. 1999;16(3):208–15.

    Article  CAS  PubMed  Google Scholar 

  17. Yang MH, Ng SC, Ratnam SS, et al. Outcome of 143 pregnancies conceived by assisted reproductive techniques. Asia Oceania J Obstet Gynaecol. 1992;18(4):299–307.

    Article  CAS  PubMed  Google Scholar 

  18. Shaw JL, Horne AW. The paracrinology of tubal ectopic pregnancy. Mol Cell Endocrinol. 2012;358(2):216–22. Epub 2011 Jul 30. PMID: 21827822; PMCID: PMC3276879. https://doi.org/10.1016/j.mce.2011.07.037.

    Article  CAS  PubMed  Google Scholar 

  19. Shaw JL, Oliver E, Lee KF, Entrican G, Jabbour HN, Critchley HO, Horne AW. Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol. 2010;177(5):2509–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Shaw JL, Wills GS, Lee KF, Horner PJ, McClure MO, Abrahams VM, Wheelhouse N, Jabbour HN, Critchley HO, Entrican G, Horne AW. Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. Am J Pathol. 2011;178(1):253–60. Epub 2010 Dec 23. PMID: 21224062; PMCID: PMC3016599. https://doi.org/10.1016/j.ajpath.2010.11.019.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Alsuleiman SA, Grimes EM. Ectopic pregnancy: a review of 147 cases. J Reprod Med. 1982;27:101–6.

    CAS  PubMed  Google Scholar 

  22. Mol F, van Mello NM, Strandell A, Strandell K, Jurkovic D, Ross J, Barnhart KT, Yalcinkaya TM, Verhoeve HR, Graziosi GCM, Koks CAM, Klinte I, Hogström L, Janssen ICAH, Kragt H, Hoek A, Trimbos-Kemper TCM, Broekmans FJM, Willemsen WNP, Ankum WM, Mol BW, van Wely M, van der Veen F, Hajenius PJ, European Surgery in Ectopic Pregnancy (ESEP) Study Group. Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial. Lancet. 2014;383(9927):1483–9. Epub 2014 Feb 3. PMID: 24499812. https://doi.org/10.1016/S0140-6736(14)60123-9.

    Article  PubMed  Google Scholar 

  23. ESHRE Working Group on Ectopic Pregnancy, Kirk E, Ankum P, Jakab A, Le Clef N, Ludwin A, Small R, Tellum T, Töyli M, Van den Bosch T, Jurkovic D. Terminology for describing normally sited and ectopic pregnancies on ultrasound: ESHRE recommendations for good practice. Hum Reprod Open. 2020;2020:hoaa055. PMID: 33354626; PMCID: PMC7738750. https://doi.org/10.1093/hropen/hoaa055.

    Article  Google Scholar 

  24. WHO Classification of Tumours Editorial Board. Female genital tumours. WHO Classification of tumour series, vol. 4. 5th ed. Lyon: International Agency for Research on Cancer; 2020. p. 309–22.

    Google Scholar 

  25. Randall S, Buckley CH, Fox H. Placentation in the fallopian tube. Int J Gynecol Pathol. 1987;6(2):132–9.

    Article  CAS  PubMed  Google Scholar 

  26. Dhingra N, Punia RS, Radotra A, Mohan H. Arias-Stella reaction in upper genital tract in pregnant and non-pregnant women: a study of 120 randomly selected cases. Arch Gynecol Obstet. 2007;276(1):47–52. Epub 2007 Jan 12. PMID: 17219163. https://doi.org/10.1007/s00404-006-0297-x.

    Article  PubMed  Google Scholar 

  27. Milchgrub S, Sandstad J. Arias-Stella reaction in fallopian tube epithelium. A light and electron microscopic study with a review of the literature. Am J Clin Pathol. 1991;95(6):892–5. PMID: 2042599. https://doi.org/10.1093/ajcp/95.6.892.

    Article  CAS  PubMed  Google Scholar 

  28. Tziortziotis DV, Bouros AC, Ziogas VS, Young RH. Clear cell hyperplasia of the fallopian tube epithelium associated with ectopic pregnancy: report of a case. Int J Gynecol Pathol. 1997;16(1):79–80. PMID: 8986537. https://doi.org/10.1097/00004347-199701000-00013.

    Article  CAS  PubMed  Google Scholar 

  29. Sebire NJ, Lindsay I, Fisher RA, Savage P, Seckl MJ. Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies. Int J Gynecol Pathol. 2005;24(3):260–4. PMID: 15968202. https://doi.org/10.1097/01.pgp.0000164597.19346.b5.

    Article  CAS  PubMed  Google Scholar 

  30. Burton JL, Lidbury EA, Gillespie AM, Tidy JA, Smith O, Lawry J, Hancock BW, Wells M. Over-diagnosis of hydatidiform mole in early tubal ectopic pregnancy. Histopathology. 2001;38(5):409–17. PMID: 11422477. https://doi.org/10.1046/j.1365-2559.2001.01151.x.

    Article  CAS  PubMed  Google Scholar 

  31. Ramirez NC, Lawrence WD, Ginsburg KA. Ectopic pregnancy. A recent five-year study and review of the last 50 years’ literature. J Reprod Med. 1996;41:733–40.

    CAS  PubMed  Google Scholar 

  32. Sib SR, Ouédraogo I, Sanogo M, Kiemtoré S, Sawadogo YA, Zamané H, Bonané B. A full term abdominal pregnancy with an isthmic tubal implantation of the placenta. BMC Pregnancy Childbirth. 2018;18(1):448. PMID: 30453918; PMCID: PMC6245774. https://doi.org/10.1186/s12884-018-2071-z.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Timor-Tritsch IE, Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review. Am J Obstet Gynecol. 2012;207(1):14–29. Epub 2012 Mar 10. Erratum in: Am J Obstet Gynecol. 2014 Apr;210(4):371-4. PMID: 22516620. https://doi.org/10.1016/j.ajog.2012.03.007.

    Article  PubMed  Google Scholar 

  34. DiMarchi JM, Kosasa TS, Kobara TY, Hale RW. Persistent ectopic pregnancy. Obstet Gynecol. 1987;70(4):555–8. PMID: 2442687.

    CAS  PubMed  Google Scholar 

  35. Kelly RW, Martin SA, Strickler RC. Delayed hemorrhage in conservative surgery for ectopic pregnancy. Am J Obstet Gynecol. 1979;133(2):225–6. PMID: 420279. https://doi.org/10.1016/0002-9378(79)90483-6.

    Article  CAS  PubMed  Google Scholar 

  36. Muto MG, Lage JM, Berkowitz RS, Goldstein DP, Bernstein MR. Gestational trophoblastic disease of the fallopian tube. J Reprod Med. 1991;36(1):57–60.

    CAS  PubMed  Google Scholar 

  37. Siozos A, Sriemevan A. A case of true tubal hydatidiform mole and literature review. BMJ Case Rep. 2010;2010:bcr0720092123. PMID: 22767681; PMCID: PMC3029073. https://doi.org/10.1136/bcr.07.2009.2123.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Lu D, Tang JJ, Zakashansky K, Berkowitz RS, Kalir T, Liu Y. Heterotopic pregnancy including intrauterine normal gestation and tubal complete hydatidiform mole: a case report and review of the literature. Int J Gynecol Pathol. 2017;36(5):428–32. https://doi.org/10.1097/PGP.000000000000034.

    Article  PubMed  Google Scholar 

  39. Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet. 2010;376(9742):717–29. Epub 2010 Jul 29. https://doi.org/10.1016/S0140-6736(10)60280-2.

    Article  PubMed  Google Scholar 

  40. Banet N, DeScipio C, Murphy KM, Beierl K, Adams E, Vang R, Ronnett BM. Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping. Mod Pathol. 2014;27(2):238–54. Epub 2013 Jul 26. https://doi.org/10.1038/modpathol.2013.143.

    Article  CAS  PubMed  Google Scholar 

  41. Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform moles: genetic basis and precision diagnosis. Annu Rev Pathol. 2017;12:449–85. PMID: 28135560. https://doi.org/10.1146/annurev-pathol-052016-100237.

    Article  CAS  PubMed  Google Scholar 

  42. Sebire NJ, Savage PM, Seckl MJ, Fisher RA. Histopathological features of biparental complete hydatidiform moles in women with NLRP7 mutations. Placenta. 2013;34(1):50–6. Epub 2012 Nov 29. PMID: 23201303. https://doi.org/10.1016/j.placenta.2012.11.005.

    Article  CAS  PubMed  Google Scholar 

  43. Genest DR. Partial hydatidiform mole: clinicopathological features, differential diagnosis, ploidy and molecular studies, and gold standards for diagnosis. Int J Gynecol Pathol. 2001;20(4):315–22.

    Article  CAS  PubMed  Google Scholar 

  44. Paradinas FJ, Browne P, Fisher RA, Foskett M, Bagshawe KD, Newlands E. A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non-molar hydropic abortions. Histopathology. 1996;28(2):101–10.

    Article  CAS  PubMed  Google Scholar 

  45. Fisher RA, Tommasi A, Short D, Kaur B, Seckl MJ, Sebire NJ. Clinical utility of selective molecular genotyping for diagnosis of partial hydatidiform mole; a retrospective study from a regional trophoblastic disease unit. J Clin Pathol. 2014;67(11):980–4. Epub 2014 Jul 30. https://doi.org/10.1136/jclinpath-2014-202517.

    Article  PubMed  Google Scholar 

  46. Cosson M, Vinatier D. Choriocarcinome tubaire: à propos d'un cas et revue de la littérature [Tubal choriocarcinoma: a case report and review of the literature]. J Gynecol Obstet Biol Reprod (Paris). 2007;36(1):83–6. French. Epub 2007 Jan 10. https://doi.org/10.1016/j.jgyn.2006.10.003.

    Article  PubMed  Google Scholar 

  47. Rettenmaier MA, Khan HJ, Epstein HD, Nguyen D, Abaid LN, Goldstein BH. Gestational choriocarcinoma in the fallopian tube. J Obstet Gynaecol. 2013;33(8):912–4. https://doi.org/10.3109/01443615.2013.834879.

    Article  CAS  PubMed  Google Scholar 

  48. Xu S, Song X, Jin C, Li Y. Tubal choriocarcinoma presented as ruptured ectopic pregnancy: a case report and review of the literature. World J Surg Oncol. 2020;18(1):245. PMID: 32919475; PMCID: PMC7488679. https://doi.org/10.1186/s12957-020-02021-4.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Fisher RA, Savage PM, MacDermott C, Hook J, Sebire NJ, Lindsay I, Seckl MJ. The impact of molecular genetic diagnosis on the management of women with hCG-producing malignancies. Gynecol Oncol. 2007;107(3):413–9. Epub 2007 Oct 22. PMID: 17942145. https://doi.org/10.1016/j.ygyno.2007.07.081.

    Article  CAS  PubMed  Google Scholar 

  50. Kurman RJ, Scully RE, Norris HJ. Trophoblastic pseudotumor of the uterus: an exaggerated form of “syncytial endometritis” simulating a malignant tumor. Cancer. 1976;38(3):1214–26.

    Article  CAS  PubMed  Google Scholar 

  51. Scully RE. Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol. 2006;100(3):511–20. Epub 2005 Oct 21. PMID: 16246400. https://doi.org/10.1016/j.ygyno.2005.08.058.

    Article  PubMed  Google Scholar 

  52. Baergen RN, Rutgers J, Young RH. Extrauterine lesions of intermediate trophoblast. Int J Gynecol Pathol. 2003;22:362–7.

    Article  PubMed  Google Scholar 

  53. Su YN, Cheng WF, Chen CA, Lin TY, Hsieh FJ, Cheng SP, Hsieh CY. Pregnancy with primary tubal placental site trophoblastic tumor—a case report and literature review. Gynecol Oncol. 1999;73(2):322–5. PMID: 10329055. https://doi.org/10.1006/gyno.1998.5318.

  54. Fisher RA, Kaur B. Molecular genotyping in the diagnosis of trophoblastic tumours. Diagnostic Histopathology. 2019;25(2):66–76.

    Google Scholar 

  55. Schmid P, Nagai Y, Agarwal R, Hancock B, Savage PM, Sebire NJ, Lindsay I, Wells M, Fisher RA, Short D, Newlands ES, Wischnewsky MB, Seckl MJ. Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study. Lancet. 2009;374(9683):48–55. Epub 2009 Jun 22. PMID: 19552948. https://doi.org/10.1016/S0140-6736(09)60618-8.

    Article  CAS  PubMed  Google Scholar 

  56. Fukunaga M, Ushigome S. Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. Hum Pathol. 1993;24(10):1098–106. PMID: 7691711. https://doi.org/10.1016/0046-8177(93)90190-r.

    Article  CAS  PubMed  Google Scholar 

  57. Zhao S, Sebire NJ, Kaur B, Seckl MJ, Fisher RA. Molecular genotyping of placental site and epithelioid trophoblastic tumours; female predominance. Gynecol Oncol. 2016;142(3):501–7. Epub 2016 Jul 4. PMID: 27246306. https://doi.org/10.1016/j.ygyno.2016.05.033.

    Article  CAS  PubMed  Google Scholar 

  58. Shih IM, Kurman RJ. Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol. 1998;22(11):1393–403. PMID: 9808132. https://doi.org/10.1097/00000478-199811000-00010.

    Article  CAS  PubMed  Google Scholar 

  59. Davis MR, Howitt BE, Quade BJ, Crum CP, Horowitz NS, Goldstein DP, Berkowitz RS. Epithelioid trophoblastic tumor: a single institution case series at the New England Trophoblastic Disease Center. Gynecol Oncol. 2015;137(3):456–61. Epub 2015 Mar 12. PMID: 25773203. https://doi.org/10.1016/j.ygyno.2015.03.006.

    Article  CAS  PubMed  Google Scholar 

  60. Parker A, Lee V, Dalrymple C, Valmadre S, Russell P. Epithelioid trophoblastic tumour: report of a case in the fallopian tube. Pathology. 2003;35(2):136–40. PMID: 12745461.

    CAS  PubMed  Google Scholar 

  61. Fadare O, Parkash V, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: clinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol. 2006;19(1):75–82. PMID: 16258513. https://doi.org/10.1038/modpathol.3800485.

    Article  CAS  PubMed  Google Scholar 

  62. Lu B, Zhang X, Liang Y. Clinicopathologic analysis of postchemotherapy gestational trophoblastic neoplasia: an entity overlapping with epithelioid trophoblastic tumor. Int J Gynecol Pathol. 2016;35(6):516–24. PMID: 26630228. https://doi.org/10.1097/PGP.0000000000000259.

    Article  CAS  PubMed  Google Scholar 

  63. Shih IM, Kurman RJ. p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Am J Surg Pathol. 2004;28(9):1177–83. PMID: 15316317. https://doi.org/10.1097/01.pas.0000130325.66448.a1.

    Article  PubMed  Google Scholar 

  64. Mao TL, Seidman JD, Kurman RJ, Shih IM. Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor—an aid in differential diagnosis. Am J Surg Pathol. 2006;30(9):1105–10. PMID: 16931955. https://doi.org/10.1097/01.pas.0000209854.28282.87.

    Article  PubMed  Google Scholar 

  65. Choi JJ, Emmadi R. Incidental placental site nodule in a fallopian tube. Int J Surg Pathol. 2013;22(1):90–2.

    Article  PubMed  Google Scholar 

  66. Baergen RN, Rutgers J, Young RH. Extrauterine lesions of intermediate trophoblast. Int J Gynecol Pathol. 2003;22(4):362–7.

    Article  PubMed  Google Scholar 

  67. Yen TT, Anderson J, Shih IM. Case report: tubal atypical placental site nodule. Int J Gynecol Pathol. 2022;41:530. Epub ahead of print. https://doi.org/10.1097/PGP.0000000000000825.

    Article  PubMed  Google Scholar 

  68. Huettner PC, Gersell PJ. Placental site nodule—a clinicopathological study of 38 cases. Int J Gynecol Pathol. 1994;13:191–8.

    Article  CAS  PubMed  Google Scholar 

  69. Young RH, Kurman RJ, Scully RE. Placental site nodules and plaques. A clinicopathologic analysis of 20 cases. Am J Surg Pathol. 1990;14(11):1001–9. https://doi.org/10.1097/00000478-199011000-00002.

    Article  CAS  PubMed  Google Scholar 

  70. Kaur B, Short D, Fisher RA, Savage PM, Seckl MJ, Sebire NJ. Atypical placental site nodule (APSN) and association with malignant gestational trophoblastic disease; a clinicopathologic study of 21 cases. Int J Gynecol Pathol. 2015;34(2):152–8. https://doi.org/10.1097/PGP.0000000000000128.

    Article  PubMed  Google Scholar 

  71. Shih IM, Kurman RJ. Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. Hum Pathol. 1998;29(1):27–33. PMID: 9445130. https://doi.org/10.1016/s0046-8177(98)90386-0.

    Article  CAS  PubMed  Google Scholar 

  72. Chew I, Post MD, Carinelli SG, Campbell S, Di Y, Soslow RA, Oliva E. p16 expression in squamous and trophoblastic lesions of the upper female genital tract. Int J Gynecol Pathol. 2010;29(6):513–22. PMID: 20881863. https://doi.org/10.1097/PGP.0b013e3181e2fe70.

    Article  PubMed  Google Scholar 

  73. Golfier F, Clerc J, Hajri T, Massardier J, Frappart L, Duvillard P, Rabreau M, Patrier S, Devisme L, Carles D, Pelluard F, Gasser B, Tarranger-Charpin C, Schott AM, Raudrant D. Contribution of referent pathologists to the quality of trophoblastic diseases diagnosis. Hum Reprod. 2011;26(10):2651–7. Epub 2011 Aug 12. PMID: 21840909. https://doi.org/10.1093/humrep/der265.

    Article  PubMed  Google Scholar 

  74. Anketell P, Kaur B. Systematic histology review of 1318 cases of gestational trophoblastic disease (GTD) referred to a tertiary referral centre in one-year period (2011). Virchows Arch. 2018;473:S34.

    Google Scholar 

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Kaur, B. (2023). Ectopic Pregnancy: Diagnosis and Complications. In: Wilkinson, N. (eds) Pathology of the Ovary, Fallopian Tube and Peritoneum. Essentials of Diagnostic Gynecological Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-39659-5_3

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