Abstract
Diagnosis and management of bone and joint infections are common ID consult questions. There is a growing trend toward divisions having specific orthopedic ID services, and some fellowship programs even offer an extra year of training in this area. As infection in bone progresses, areas of necrosis develop which can make medical management and source control challenging. Infected hardware is another challenge in musculoskeletal ID. Microbes rapidly create biofilm on foreign material and become protected from both the host immune system and antibiotic therapy. Removal of hardware in itself may pose serious risks to the patient so decision-making can be very complex. As in many facets of ID, patients with musculoskeletal infection often benefit from a multidisciplinary approach between ID, surgical services, musculoskeletal radiology, and pathology.
In this chapter, we will start by examining questions that broadly apply to orthopedic infection, such as when oral antibiotics can be used for treatment, what type of antibiotic prophylaxis should be used for orthopedic surgery, and the role of rifampin in orthopedic infection. We will then discuss specific types of musculoskeletal infections, ranging from tendon to periprosthetic joint infection.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Li H-K, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C, Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN, Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P, Scarborough M, Trial Collaborators OVIVA. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019;380:425–36. https://doi.org/10.1056/NEJMoa1710926.
Azamgarhi T, Shah A, Warren S. Clinical experience of implementing Oral versus intravenous antibiotics (OVIVA) in a specialist orthopedic hospital. Clin Infect Dis. 2021;73:e2582–8. https://doi.org/10.1093/cid/ciaa985.
Passerini M, Maamari J, Nayfeh T, Hassett LC, Tande AJ, Murad MH, Temesgen Z, Berbari EF. Early switch to oral antibiotic therapy for the treatment of patients with bacterial native vertebral osteomyelitis: a quaternary center experience, systematic review, and meta-analysis. J Bone Jt Infect. 2022;7:249–57. https://doi.org/10.5194/jbji-7-249-2022.
Macy E, Poon K-YT. Self-reported antibiotic allergy incidence and prevalence: age and sex effects. Am J Med. 2009;122:778.e1–7. https://doi.org/10.1016/j.amjmed.2009.01.034.
Blumenthal KG, Wickner PG, Hurwitz S, Pricco N, Nee AE, Laskowski K, Shenoy ES, Walensky RP. Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship. J Allergy Clin Immunol. 2017;140:154–161.e6. https://doi.org/10.1016/j.jaci.2017.02.005.
Tatara AM, Nelson SB. Antibiotic prophylaxis for total joint arthroplasty. Instr Course Lect. 2022;71:107–16.
Zastrow RK, Huang H-H, Galatz LM, Saunders-Hao P, Poeran J, Moucha CS. Characteristics of antibiotic prophylaxis and risk of surgical site infections in primary total hip and knee arthroplasty. J Arthroplast. 2020;35:2581–9. https://doi.org/10.1016/j.arth.2020.04.025.
Blumenthal KG, Ryan EE, Li Y, Lee H, Kuhlen JL, Shenoy ES. The impact of a reported penicillin allergy on surgical site infection risk. Clin Infect Dis. 2018;66:329–36. https://doi.org/10.1093/cid/cix794.
Lam PW, Tarighi P, Elligsen M, Nathens AB, Riegert D, Tarshis J, Leis JA. Impact of the allergy clarification for cefazolin evidence-based prescribing tool on receipt of preferred perioperative prophylaxis: an interrupted time series study. Clin Infect Dis. 2020;71:2955–7. https://doi.org/10.1093/cid/ciaa516.
Cortés-Penfield NW, Kulkarni PA. The history of antibiotic treatment of osteomyelitis. Open Forum Infect Dis. 2019;6:ofz181. https://doi.org/10.1093/ofid/ofz181.
Zimmerli W, Sendi P. Role of rifampin against staphylococcal biofilm infections in vitro, in animal models, and in orthopedic-device-related infections. Antimicrob Agents Chemother. 2019;63 https://doi.org/10.1128/AAC.01746-18.
Monk M, Elshaboury R, Tatara A, Nelson S, Bidell MR. A case series of rifabutin use in staphylococcal prosthetic infections. Microbiol Spectr. 2022;10:e0038422. https://doi.org/10.1128/spectrum.00384-22.
Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-body infection (FBI) study group. JAMA. 1998;279:1537–41. https://doi.org/10.1001/jama.279.19.1537.
Stengel D, Bauwens K, Sehouli J, Ekkernkamp A, Porzsolt F. Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. Lancet Infect Dis. 2001;1:175–88. https://doi.org/10.1016/S1473-3099(01)00094-9.
Beldman M, Löwik C, Soriano A, Albiach L, Zijlstra WP, Knobben BAS, Jutte P, Sousa R, Carvalho A, Goswami K, Parvizi J, Belden KA, Wouthuyzen-Bakker M. If, when, and how to use rifampin in acute staphylococcal periprosthetic joint infections, a multicentre observational study. Clin Infect Dis. 2021;73:1634–41. https://doi.org/10.1093/cid/ciab426.
Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of Americaa. Clin Infect Dis. 2013;56:e1–e25. https://doi.org/10.1093/cid/cis803.
Karau MJ, Schmidt-Malan SM, Albano M, Mandrekar JN, Rivera CG, Osmon DR, Oravec CP, Berry DJ, Abdel MP, Patel R. Novel use of rifabutin and rifapentine to treat methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis. J Infect Dis. 2020;222:1498. https://doi.org/10.1093/infdis/jiaa401.
Luna B, Trebosc V, Lee B, Bakowski M, Ulhaq A, Yan J, Lu P, Cheng J, Nielsen T, Lim J, Ketphan W, Eoh H, McNamara C, Skandalis N, She R, Kemmer C, Lociuro S, Dale GE, Spellberg B. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Nat Microbiol. 2020;5:1134–43. https://doi.org/10.1038/s41564-020-0737-6.
Doub JB, Heil EL, Ntem-Mensah A, Neeley R, Ching PR. Rifabutin use in staphylococcus biofilm infections: a case series. Antibiotics. 2020;9 https://doi.org/10.3390/antibiotics9060326.
Ross JJ, Shamsuddin H. Sternoclavicular septic arthritis: review of 180 cases. Medicine (Baltimore). 2004;83:139–48. https://doi.org/10.1097/01.md.0000126761.83417.29.
Womack J. Septic arthritis of the sternoclavicular joint. J Am Board Fam Med. 2012;25:908–12. https://doi.org/10.3122/jabfm.2012.06.110196.
Jang Y-R, Kim T, Kim M-C, Sup Sung H, Kim M-N, Kim MJ, Kim SH, Lee S-O, Choi S-H, Woo JH, Kim YS, Chong YP. Sternoclavicular septic arthritis caused by Staphylococcus aureus: excellent results from medical treatment and limited surgery. Infect Dis (Lond). 2019;51:694–700. https://doi.org/10.1080/23744235.2019.1639810.
von Glinski A, Yilmaz E, Rausch V, Koenigshausen M, Schildhauer TA, Seybold D, Geßmann J. Surgical management of sternoclavicular joint septic arthritis. J Clin Orthop Trauma. 2019;10:406–13. https://doi.org/10.1016/j.jcot.2018.05.001.
Wouters R, Wellens F, Vanermen H, De Geest R, Degrieck I, De Meerleer F. Sternitis and mediastinitis after coronary artery bypass grafting. Analysis of risk factors. Tex Heart Inst J. 1994;21:183–8.
Tegnell A, Arén C, Ohman L. Coagulase-negative staphylococci and sternal infections after cardiac operation. Ann Thorac Surg. 2000;69:1104–9. https://doi.org/10.1016/s0003-4975(99)01563-5.
Ledermann HP, Morrison WB, Schweitzer ME, Raikin SM. Tendon involvement in pedal infection: MR analysis of frequency, distribution, and spread of infection. AJR Am J Roentgenol. 2002;179:939–47. https://doi.org/10.2214/ajr.179.4.1790939.
Pajala A, Kangas J, Ohtonen P, Leppilahti J. Rerupture and deep infection following treatment of total Achilles tendon rupture. J Bone Joint Surg Am. 2002;84:2016–21. https://doi.org/10.2106/00004623-200211000-00017.
Jildeh TR, Okoroha KR, Marshall NE, Abdul-Hak A, Zeni F, Moutzouros V. Infection and rerupture after surgical repair of achilles tendons. Orthop J Sports Med. 2018;6:2325967118774302. https://doi.org/10.1177/2325967118774302.
Wong D, Holtom P, Spellberg B. Osteomyelitis complicating sacral pressure ulcers: whether or not to treat with antibiotic therapy. Clin Infect Dis. 2019;68:338–42. https://doi.org/10.1093/cid/ciy559.
Türk EE, Tsokos M, Delling G. Autopsy-based assessment of extent and type of osteomyelitis in advanced-grade sacral decubitus ulcers: a histopathologic study. Arch Pathol Lab Med. 2003;127:1599–602. https://doi.org/10.5858/2003-127-1599-AAOEAT.
Darouiche RO, Landon GC, Klima M, Musher DM, Markowski J. Osteomyelitis associated with pressure sores. Arch Intern Med. 1994;154:753–8.
Sugarman B, Hawes S, Musher DM, Klima M, Young EJ, Pircher F. Osteomyelitis beneath pressure sores. Arch Intern Med. 1983;143:683–8.
Brunel A-S, Lamy B, Cyteval C, Perrochia H, Téot L, Masson R, Bertet H, Bourdon A, Morquin D, Reynes J, Le Moing V, OSTEAR Study Group. Diagnosing pelvic osteomyelitis beneath pressure ulcers in spinal cord injured patients: a prospective study. Clin Microbiol Infect. 2016;22:267.e1–8. https://doi.org/10.1016/j.cmi.2015.11.005.
Marriott R, Rubayi S. Successful truncated osteomyelitis treatment for chronic osteomyelitis secondary to pressure ulcers in spinal cord injury patients. Ann Plast Surg. 2008;61:425–9. https://doi.org/10.1097/SAP.0b013e318162f257.
Patel R. Periprosthetic joint infection. N Engl J Med. 2023;388:251–62. https://doi.org/10.1056/NEJMra2203477.
Byren I, Bejon P, Atkins BL, Angus B, Masters S, McLardy-Smith P, Gundle R, Berendt A. One hundred and twelve infected arthroplasties treated with ‘DAIR’ (debridement, antibiotics and implant retention): antibiotic duration and outcome. J Antimicrob Chemother. 2009;63:1264–71. https://doi.org/10.1093/jac/dkp107.
Bedair HS, Katakam A, Bedeir YH, Yeroushalmi D, Schwarzkopf R. A decision analysis of treatment strategies for acute periprosthetic joint infection: early irrigation and debridement versus delayed treatment based on organism. J Orthop. 2020;22:246–50. https://doi.org/10.1016/j.jor.2020.04.003.
Kunutsor SK, Beswick AD, Whitehouse MR, Wylde V, Blom AW. Debridement, antibiotics and implant retention for periprosthetic joint infections: a systematic review and meta-analysis of treatment outcomes. J Infect. 2018;77:479–88. https://doi.org/10.1016/j.jinf.2018.08.017.
Belden K, Cao L, Chen J, Deng T, Fu J, Guan H, Jia C, Kong X, Kuo F-C, Li R, Repetto I, Riccio G, Tarabichi M. Hip and knee section, fungal periprosthetic joint infection, diagnosis and treatment: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S387–91. https://doi.org/10.1016/j.arth.2018.09.023.
Shah NB, Hersh BL, Kreger A, Sayeed A, Bullock AG, Rothenberger SD, Klatt B, Hamlin B, Urish KL. Benefits and adverse events associated with extended antibiotic use in total knee arthroplasty periprosthetic joint infection. Clin Infect Dis. 2020;70:559–65. https://doi.org/10.1093/cid/ciz261.
Lange J, Troelsen A, Thomsen RW, Søballe K. Chronic infections in hip arthroplasties: comparing risk of reinfection following one-stage and two-stage revision: a systematic review and meta-analysis. Clin Epidemiol. 2012;4:57–73. https://doi.org/10.2147/CLEP.S29025.
Kunutsor SK, Whitehouse MR, Blom AW, Beswick AD, INFORM Team. Re-infection outcomes following one- and two-stage surgical revision of infected hip prosthesis: a systematic review and meta-analysis. PLoS One. 2015;10:e0139166. https://doi.org/10.1371/journal.pone.0139166.
Bernard L, Arvieux C, Brunschweiler B, Touchais S, Ansart S, Bru J-P, Oziol E, Boeri C, Gras G, Druon J, Rosset P, Senneville E, Bentayeb H, Bouhour D, Le Moal G, Michon J, Aumaître H, Forestier E, Laffosse J-M, Begué T, Chirouze C, Dauchy F-A, Devaud E, Martha B, Burgot D, Boutoille D, Stindel E, Dinh A, Bemer P, Giraudeau B, Issartel B, Caille A. Antibiotic therapy for 6 or 12 weeks for prosthetic joint infection. N Engl J Med. 2021;384:1991–2001. https://doi.org/10.1056/NEJMoa2020198.
Malcolm TL, Gad BV, Elsharkawy KA, Higuera CA. Complication, survival, and reoperation rates following Girdlestone resection arthroplasty. J Arthroplast. 2015;30:1183–6. https://doi.org/10.1016/j.arth.2015.02.011.
Sharma H, Kakar R. Outcome of Girdlestone’s resection arthroplasty following complications of proximal femoral fractures. Acta Orthop Belg. 2006;72:555–9.
Wixted CM, Polascik BA, Cochrane NH, Antonelli B, Muthusamy N, Ryan SP, Chen AF, Schwarzkopf R, Seyler TM. A multicenter prospective investigation on patient physical and mental health after girdlestone resection arthroplasty. J Arthroplast. 2022;S0883-5403(22):01091–9. https://doi.org/10.1016/j.arth.2022.12.016.
Calabrò F, Coen M, Franceschini M, Franco-Cendejas R, Hewlett A, Segreti J, Senneville E. Hip and knee section, treatment, antimicrobial suppression: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S483–5. https://doi.org/10.1016/j.arth.2018.09.034.
Prendki V, Ferry T, Sergent P, Oziol E, Forestier E, Fraisse T, Tounes S, Ansart S, Gaillat J, Bayle S, Ruyer O, Borlot F, Le Falher G, Simorre B, Dauchy F-A, Greffe S, Bauer T, Bell EN, Martha B, Martinot M, Froidure M, Buisson M, Waldner A, Lemaire X, Bosseray A, Maillet M, Charvet V, Barrelet A, Wyplosz B, Noaillon M, Denes E, Beretti E, Berlioz-Thibal M, Meyssonnier V, Fourniols E, Tliba L, Eden A, Jean M, Arvieux C, Guignery-Kadri K, Ronde-Oustau C, Hansmann Y, Belkacem A, Bouchand F, Gavazzi G, Herrmann F, Stirnemann J, Dinh A. Prolonged suppressive antibiotic therapy for prosthetic joint infection in the elderly: a national multicentre cohort study. Eur J Clin Microbiol Infect Dis. 2017;36:1577–85. https://doi.org/10.1007/s10096-017-2971-2.
Rao N, Crossett LS, Sinha RK, Le Frock JL. Long-term suppression of infection in total joint arthroplasty. Clin Orthop Relat Res. 2003;55–60:55. https://doi.org/10.1097/01.blo.0000087321.60612.cf.
Keller SC, Cosgrove SE, Higgins Y, Piggott DA, Osgood G, Auwaerter PG. Role of suppressive oral antibiotics in orthopedic hardware infections for those not undergoing two-stage replacement surgery. Open Forum Infect Dis. 2016;3:ofw176. https://doi.org/10.1093/ofid/ofw176.
Lau JSY, Bhatt S, Streitberg R, Bryant M, Korman TM, Woolley I. Surveillance of life-long antibiotics-a cross-sectional cohort study assessing patient attitudes and understanding of long-term antibiotic consumption. Infect Dis Health. 2019;24:179–86. https://doi.org/10.1016/j.idh.2019.05.002.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Tatara, A.M. (2023). Musculoskeletal Infection. In: The Infectious Diseases Consult Handbook. Springer, Cham. https://doi.org/10.1007/978-3-031-39474-4_13
Download citation
DOI: https://doi.org/10.1007/978-3-031-39474-4_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-39473-7
Online ISBN: 978-3-031-39474-4
eBook Packages: MedicineMedicine (R0)