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Genetics of Hypertension and Heart Failure

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Hypertension and Heart Failure

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

Abstract

Hypertension and heart failure (HF) are the leading causes of death and disability worldwide. Both are complex multifactorial conditions with each at either ends of the cardiovascular continuum. Rare mutations resulting in monogenic forms of hypertension, hypotension, and cardiomyopathies highlight the importance of genetics in disease causation and the consequent implications for disease prediction and treatment. Accelerating advances in genomics over the last decade have led to an unparalleled leap in our understanding of the genetic architecture of both hypertension and heart failure. In this chapter, we describe the current state of the art in the genetics of both conditions, focusing on the biological pathways that are perturbed and opportunities for early detection and treatment.

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Authors and Affiliations

  1. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK

    Sandosh Padmanabhan, Clea du Toit & Anna F. Dominiczak

  2. Medicine, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK

    Anna F. Dominiczak

Authors
  1. Sandosh Padmanabhan
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  2. Clea du Toit
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  3. Anna F. Dominiczak
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Correspondence to Anna F. Dominiczak .

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Editors and Affiliations

  1. Carol Davila University of Medicine and Pharmacy, Bucharest, Bucuresti, Romania

    Maria Dorobantu

  2. Department of Pharmacology, Toxicology and Clinical Psychopharmacology Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Victor Voicu

  3. University of Milano-Bicocca, Milano, Italy

    Guido Grassi

  4. Dept of Clinical and Experimental Sci, University of Brescia, Brescia, Italy

    Enrico Agabiti-Rosei

  5. University of Milano-Bicocca, Milano, Italy

    Giuseppe Mancia

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Padmanabhan, S., du Toit, C., Dominiczak, A.F. (2023). Genetics of Hypertension and Heart Failure. In: Dorobantu, M., Voicu, V., Grassi, G., Agabiti-Rosei, E., Mancia, G. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-031-39315-0_4

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