Skip to main content

An Update on the Prevalence of Heart Failure

  • Chapter
  • First Online:
Hypertension and Heart Failure

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

  • 143 Accesses

Abstract

Heart failure (HF) constitutes a global public health problem. The clinical epidemiology of HF has not been clearly appreciated over the world. In addition, the prevalence of HF reported in the literature depends on the definition used. No data are available yet on HF prevalence in accordance with the new 2021 European Society of Cardiology (ESC) and 2022 American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA) guideline definitions. In developed countries, the prevalence of HF ranges between 1% and 3% of the general adult population. Estimates from low-income countries are scarce. HF is particularly prevalent among older individuals. According to registry data from Western countries, up to roughly 50% of patients have HF with a reduced ejection fraction (EF). This subtype of HF is most likely to remain stable or even decline, whereas the prevalence of HF with preserved EF is steadily increasing. The total number of HF patients is still continuing to rise due to a growing and aging population, improved availability of diagnostic tools, and progress in medical treatments that aid in prolonging life. These findings indicate that the worldwide epidemic of HF may progress even more rapidly than assumed so far. It is also important to establish the role of asymptomatic left ventricular dysfunction (ALVD) in the natural history of HF and the potential for its prevention.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–858. https://doi.org/10.1016/S0140-6736(18)32279-7. Epub 2018 Nov 8. Erratum in: Lancet. 2019 Jun 22;393(10190):e44. PMID: 30496104; PMCID: PMC6227754.

    Article  Google Scholar 

  2. Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020;22(8):1342–56. https://doi.org/10.1002/ejhf.1858. Epub 2020 Jun 1. PMID: 32483830; PMCID: PMC7540043.

    Article  Google Scholar 

  3. Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–87. https://doi.org/10.1093/cvr/cvac013. PMID: 35150240.

    Article  CAS  Google Scholar 

  4. Dunlay SM, Roger VL, Killian JM, Weston SA, Schulte PJ, Subramaniam AV, Blecker SB, Redfield MM. Advanced heart failure epidemiology and outcomes: a population-based study. JACC Heart Fail. 2021;9(10):722–32. https://doi.org/10.1016/j.jchf.2021.05.009. Epub 2021 Aug 11. PMID: 34391736; PMCID: PMC8487916.

    Article  Google Scholar 

  5. McKee P, Castelli W, McNamara P, et al. The natural history of congestive heart failure: the Framingham study. N Engl J Med. 1971;285(26):1441–6. https://doi.org/10.1056/nejm197112232852601.

    Article  CAS  Google Scholar 

  6. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation. 2022;145(18):e895–1032. https://doi.org/10.1161/CIR.0000000000001063. Epub 2022 Apr 1. Erratum in: Circulation. 2022 May 3;145(18):e1033. Erratum in: Circulation. 2022 Sep 27;146(13):e185. PMID: 35363499.

    Article  Google Scholar 

  7. Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352–80. https://doi.org/10.1002/ejhf.2115. Epub 2021 Mar 3. PMID: 33605000.

    Article  Google Scholar 

  8. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A, ESC Scien-tific Document Group. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–726. https://doi.org/10.1093/eurheartj/ehab368. Erratum in: Eur Heart J. 2021 Oct 14; PMID: 34447992.

    Article  CAS  Google Scholar 

  9. Wenzel JP, Nikorowitsch J, Bei der Kellen R, Magnussen C, Bonin-Schnabel R, Westermann D, Twerenbold R, Kirchhof P, Blankenberg S, Schrage B. Heart failure in the general population and impact of the 2021 European Society of Cardiology Heart Failure Guidelines. ESC Heart Fail. 2022;9(4):2157–69. https://doi.org/10.1002/ehf2.13948. Epub 2022 Apr 20. PMID: 35445582; PMCID: PMC9288760.

    Article  Google Scholar 

  10. Behnoush AH, Khalaji A, Naderi N, Ashraf H, von Haehling S. ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison. ESC Heart Fail. 2022;10(3):1531–44. https://doi.org/10.1002/ehf2.14255. PMID: 36460629.

    Article  Google Scholar 

  11. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D’Agostino RB, Kannel WB, Murabito JM, Vasan RS, Benjamin EJ, Levy D, Framingham Heart Study. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation. 2002;106(24):3068–72. https://doi.org/10.1161/01.cir.0000039105.49749.6f. PMID: 12473553.

    Article  Google Scholar 

  12. Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW, Witteman JC, Stricker BH. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J. 2004;25(18):1614–9. https://doi.org/10.1016/j.ehj.2004.06.038. PMID: 15351160.

    Article  Google Scholar 

  13. Huffman MD, Berry JD, Ning H, Dyer AR, Garside DB, Cai X, Daviglus ML, Lloyd-Jones DM. Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project. J Am Coll Cardiol. 2013;61(14):1510–7. https://doi.org/10.1016/j.jacc.2013.01.022. PMID: 23500287; PMCID: PMC3618527.

    Article  Google Scholar 

  14. Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014;383(9932):1899–911. https://doi.org/10.1016/S0140-6736(14)60685-1. PMID: 24881994; PMCID: PMC4042017.

    Article  Google Scholar 

  15. Ceia F, Fonseca C, Mota T, Morais H, Matias F, de Sousa A, Oliveira A, EPICA Investigators. Prevalence of chronic heart failure in Southwestern Europe: the EPICA study. Eur J Heart Fail. 2002;4(4):531–9. https://doi.org/10.1016/s1388-9842(02)00034-x. PMID: 12167394.

    Article  Google Scholar 

  16. Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289(2):194–202. https://doi.org/10.1001/jama.289.2.194. PMID: 12517230.

    Article  Google Scholar 

  17. Anguita Sánchez M, Crespo Leiro MG, de Teresa Galván E, Jiménez Navarro M, Alonso-Pulpón L, Muñiz García J, PRICE Study Investigators. Prevalence of heart failure in the Spanish general population aged over 45 years. The PRICE Study. Rev Esp Cardiol. 2008;61(10):1041–9. https://doi.org/10.1016/s1885-5857(09)60007-4. PMID: 18817680.

    Article  Google Scholar 

  18. Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O’Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67–492. https://doi.org/10.1161/CIR.0000000000000558. Epub 2018 Jan 31. Erratum in: Circulation. 2018 Mar 20;137(12 ):e493. PMID: 29386200.

    Article  Google Scholar 

  19. Störk S, Handrock R, Jacob J, Walker J, Calado F, Lahoz R, Hupfer S, Klebs S. Epidemiology of heart failure in Germany: a retrospective database study. Clin Res Cardiol. 2017;106(11):913–22. https://doi.org/10.1007/s00392-017-1137-7. Epub 2017 Jul 26. PMID: 28748265; PMCID: PMC5655572.

    Article  Google Scholar 

  20. Smeets M, Vaes B, Mamouris P, Van Den Akker M, Van Pottelbergh G, Goderis G, Janssens S, Aertgeerts B, Henrard S. Burden of heart failure in Flemish general practices: a registry-based study in the Intego database. BMJ Open. 2019;9(1):e022972. https://doi.org/10.1136/bmjopen-2018-022972. PMID: 30617099; PMCID: PMC6326340.

    Article  Google Scholar 

  21. Liew D, Audehm RG, Haikerwal D, Piazza P, Neville AM, Lim K, Parsons RW, Sindone AP. Epidemiology of heart failure: Study of Heart failure in the Australian Primary carE setting (SHAPE). ESC Heart Fail. 2020;7(6):3871–80. https://doi.org/10.1002/ehf2.12979. Epub 2020 Sep 9. PMID: 32902206; PMCID: PMC7754764.

    Article  Google Scholar 

  22. Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, Allison M, Hemingway H, Cleland JG, McMurray JJV, Rahimi K. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018;391(10120):572–80. https://doi.org/10.1016/S0140-6736(17)32520-5. Epub 2017 Nov 21. PMID: 29174292; PMCID: PMC5814791.

    Article  Google Scholar 

  23. Lindmark K, Boman K, Olofsson M, Törnblom M, Levine A, Castelo-Branco A, Schlienger R, Bruce Wirta S, Stålhammar J, Wikström G. Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden. Clin Epidemiol. 2019;11:231–44. https://doi.org/10.2147/CLEP.S170873. PMID: 30962724; PMCID: PMC6435223.

    Article  Google Scholar 

  24. Zarrinkoub R, Wettermark B, Wändell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T. The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. Eur J Heart Fail. 2013;15(9):995–1002. https://doi.org/10.1093/eurjhf/hft064. Epub 2013 May 3. PMID: 23645498.

    Article  Google Scholar 

  25. Ødegaard KM, Hallén J, Lirhus SS, Melberg HO, Halvorsen S. Incidence, prevalence, and mortality of heart failure: a nationwide registry study from 2013 to 2016. ESC Heart Fail. 2020;7(4):1917–26. https://doi.org/10.1002/ehf2.12773. Epub 2020 Jun 12. PMID: 32530563; PMCID: PMC7373922.

    Article  Google Scholar 

  26. Piccinni C, Antonazzo IC, Simonetti M, Mennuni MG, Parretti D, Cricelli C, Colombo D, Nica M, Cricelli I, Lapi F. The burden of chronic heart failure in primary care in Italy. High Blood Press Cardiovasc Prev. 2017;24(2):171–8. https://doi.org/10.1007/s40292-017-0193-4. Epub 2017 Mar 21. PMID: 28324597.

    Article  Google Scholar 

  27. Seferović PM, Vardas P, Jankowska EA, Maggioni AP, Timmis A, Milinković I, Polovina M, Gale CP, Lund LH, Lopatin Y, Lainscak M, Savarese G, Huculeci R, Kazakiewicz D, Coats AJS. National Heart Failure Societies of the ESC member countries (see Appendix). The Heart Failure Association Atlas: heart failure epidemiology and management statistics 2019. Eur J Heart Fail. 2021;23(6):906–14. https://doi.org/10.1002/ejhf.2143. Epub 2021 Mar 13. PMID: 33634931.

    Article  Google Scholar 

  28. Ziaeian B, Fonarow GC. Making heart failure count. Eur J Heart Fail. 2021;23(6):917–8. https://doi.org/10.1002/ejhf.2148. Epub 2021 Mar 18. PMID: 33713517; PMCID: PMC8286334.

    Article  Google Scholar 

  29. van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH. Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review. Eur J Heart Fail. 2016;18(3):242–52. https://doi.org/10.1002/ejhf.483. Epub 2016 Jan 4. PMID: 26727047.

    Article  Google Scholar 

  30. Caruana L, Petrie MC, Davie AP, McMurray JJ. Do patients with suspected heart failure and preserved left ventricular systolic function suffer from “diastolic heart failure” or from misdiagnosis? A prospective descriptive study. BMJ. 2000;321(7255):215–8. https://doi.org/10.1136/bmj.321.7255.215. PMID: 10903655; PMCID: PMC27439.

    Article  CAS  Google Scholar 

  31. Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, Naghavi M, Mensah GA, Murray CJ. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372(14):1333–41. https://doi.org/10.1056/NEJMoa1406656. PMID: 25830423; PMCID: PMC4482354.

    Article  CAS  Google Scholar 

  32. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355(3):251–9. https://doi.org/10.1056/NEJMoa052256. PMID: 16855265.

    Article  CAS  Google Scholar 

  33. van Riet EE, Hoes AW, Limburg A, Landman MA, van der Hoeven H, Rutten FH. Prevalence of unrecognized heart failure in older persons with shortness of breath on exertion. Eur J Heart Fail. 2014;16(7):772–7. https://doi.org/10.1002/ejhf.110. Epub 2014 May 26. PMID: 24863953.

    Article  CAS  Google Scholar 

  34. Boonman-de Winter LJ, Rutten FH, Cramer MJ, Landman MJ, Liem AH, Rutten GE, Hoes AW. High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia. 2012;55(8):2154–62. https://doi.org/10.1007/s00125-012-2579-0. Epub 2012 May 18. PMID: 22618812; PMCID: PMC3390708.

    Article  CAS  Google Scholar 

  35. Chioncel O, Lainscak M, Seferovic PM, Anker SD, Crespo-Leiro MG, Harjola VP, Parissis J, Laroche C, Piepoli MF, Fonseca C, Mebazaa A, Lund L, Ambrosio GA, Coats AJ, Ferrari R, Ruschitzka F, Maggioni AP, Filippatos G. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574–85. https://doi.org/10.1002/ejhf.813. Epub 2017 Apr 6. PMID: 28386917.

    Article  CAS  Google Scholar 

  36. Koh AS, Tay WT, Teng THK, Vedin O, Benson L, Dahlstrom U, Savarese G, Lam CSP, Lund LH. A comprehensive population-based characterization of heart failure with mid-range ejection fraction. Eur J Heart Fail. 2017;19(12):1624–34. https://doi.org/10.1002/ejhf.945. Epub 2017 Sep 25. PMID: 28948683.

    Article  Google Scholar 

  37. Santas E, de la Espriella R, Palau P, Miñana G, Amiguet M, Sanchis J, Lupón J, Bayes-Genís A, Chorro FJ, Núñez Villota J. Rehospitalization burden and morbidity risk in patients with heart failure with mid-range ejection fraction. ESC Heart Fail. 2020;7(3):1007–14. https://doi.org/10.1002/ehf2.12683. Epub 2020 Mar 25. PMID: 32212327; PMCID: PMC7261530.

    Article  Google Scholar 

  38. Cheng RK, Cox M, Neely ML, Heidenreich PA, Bhatt DL, Eapen ZJ, Hernandez AF, Butler J, Yancy CW, Fonarow GC. Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population. Am Heart J. 2014;168(5):721–30. https://doi.org/10.1016/j.ahj.2014.07.008. Epub 2014 Jul 22. PMID: 25440801.

    Article  Google Scholar 

  39. Joseph P, Dokainish H, McCready T, Budaj A, Roy A, Ertl G, Gomez-Mesa JE, Leong D, Ezekowitz J, Hage C, Lanas F, Maggioni AP, Sliwa K, Zhu J, Rouleau J, Balasubramanian K, Yusuf S, G-CHF Investigators. A multinational registry to study the characteristics and outcomes of heart failure patients: the global congestive heart failure (G-CHF) registry. Am Heart J. 2020;227:56–63. https://doi.org/10.1016/j.ahj.2020.06.002. Epub 2020 Jun 6. PMID: 32679282.

    Article  Google Scholar 

  40. Vasan RS, Xanthakis V, Lyass A, Andersson C, Tsao C, Cheng S, Aragam J, Benjamin J, Larson MG. Epidemiology of left ventricular systolic dysfunction and heart failure in the Framingham Study: an echocardiographic study over 3 decades. JACC Cardiovasc Imaging. 2018;11(1):1–11. https://doi.org/10.1016/j.jcmg.2017.08.007. Epub 2017 Oct 5. PMID: 28917679; PMCID: PMC5756128.

    Article  Google Scholar 

  41. Wang TJ, Evans JC, Benjamin EJ, Levy D, LeRoy EC, Vasan RS. Natural history of asymptomatic left ventricular systolic dysfunction in the community. Circulation. 2003;108(8):977–82. https://doi.org/10.1161/01.CIR.0000085166.44904.79. Epub 2003 Aug 11. PMID: 12912813.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tomasz Zdrojewski .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Zdrojewski, T. (2023). An Update on the Prevalence of Heart Failure. In: Dorobantu, M., Voicu, V., Grassi, G., Agabiti-Rosei, E., Mancia, G. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-031-39315-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-39315-0_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-39314-3

  • Online ISBN: 978-3-031-39315-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics