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Atrial Fibrillation, Hypertension, and Heart Failure

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Hypertension and Heart Failure

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Atrial fibrillation (AF) is the most common and clinically significant cardiac arrhythmia and, independently, its presentation, either symptomatic or silent, is a major risk factor for stroke. It occurs in 1–2% of the general population and accounts for one-third of all patient discharges, with arrhythmia as the principal diagnosis. Several risk factors, such as age, hypertension, diabetes mellitus, obesity, obstructive sleep apnea, left ventricular (LV) hypertrophy, coronary artery disease, heart failure (HF), and others, contribute to the development of AF [1, 2].

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References

  1. Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82:2N–9N.

    Article  CAS  Google Scholar 

  2. Manolis AJ, Kallistratos MS, Poulimenos LE. Recent clinical trials in atrial fibrillation in hypertensive patients. Curr Hypertens Rep. 2012;14:350–9. https://doi.org/10.1007/s11906-012-0268-5.

    Article  CAS  Google Scholar 

  3. Keamy PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.

    Article  Google Scholar 

  4. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–104. https://doi.org/10.1093/eurheartj/ehy339. Erratum in: Eur Heart J 2019 Feb 1;40(5):475.

    Article  Google Scholar 

  5. Manolis A, Doumas M, Poulimenos L, Kallistratos M, Mancia G. The unappreciated importance of blood pressure in recent and older atrial fibrillation trials. J Hypertens. 2013;31(11):2109–17. https://doi.org/10.1097/HJH.0b013e3283638194. discussion 2117.

    Article  CAS  Google Scholar 

  6. Manolis AJ, Agabiti-Rosei E, Coca A, Cifkova R, Erdine S, Kjeldsen S, et al. Hypertension and atrial fibrillation: diagnostic approach, prevention, and treatment. Position paper of the working group ‘hypertension, arrhythmias and thrombosis’ of the European Society of Hypertension. J Hypertens. 2012;30:239–52.

    Article  CAS  Google Scholar 

  7. Kalogeropoulos AS, Tsiodras S, Rigopoulos AG, Sakadakis EA, Triantafyllis A, Kremastinos DT, Rizos I. Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation. BMC Cardiovasc Disord. 2011;11:77. https://doi.org/10.1186/1471-2261-11-77. PMID: 22204652; PMCID: PMC3276440.

    Article  CAS  Google Scholar 

  8. Goette A, Kalman JM, Aguinaga L, et al. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Europace. 2016;18(10):1455–90. https://doi.org/10.1093/europace/euw161.

    Article  Google Scholar 

  9. Kumagai K, Nakashima H, Urata H, Gondo N, Arakawa K, Saku K. Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Am Coll Cardiol. 2003;41(12):2197–204. https://doi.org/10.1016/s0735-1097(03)00464-9.

    Article  CAS  Google Scholar 

  10. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 guidelines for the Management of Arterial Hypertension: the task force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–87.

    Article  CAS  Google Scholar 

  11. Lip GY, Tse HF. Management of atrial fibrillation. Lancet. 2012;370:604–18.

    Article  Google Scholar 

  12. Hart RG, Benavente O, McBride R, Pearce LA. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med. 1999;131:492–501.

    Article  CAS  Google Scholar 

  13. Lansberg MG, O'Donnell MJ, Khatri P, et al. Antithrombotic and thrombolytic therapy for ischemic stroke: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e601S–36S. https://doi.org/10.1378/chest.11-2302.

    Article  CAS  Google Scholar 

  14. Turnbull F, Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527–35. https://doi.org/10.1016/s0140-6736(03)14739-3.

    Article  CAS  Google Scholar 

  15. Reboldi G, Gentile G, Angeli F, Ambrosio G, Mancia G, Verdecchia P. Effects of intensive blood pressure reduction on myocardial infarction and stroke in diabetes: a meta-analysis in 73,913 patients. J Hypertens. 2011;29(7):1253–69. https://doi.org/10.1097/HJH.0b013e3283469976.19. Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment.

    Article  CAS  Google Scholar 

  16. Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. Br Med Bull. 1994;50(2):272–98. https://doi.org/10.1093/oxfordjournals.bmb.a072892.

    Article  CAS  Google Scholar 

  17. Arima H, Chalmers J, Woodward M, Anderson C, Rodgers A, Davis S, Macmahon S, Neal B, PROGRESS Collaborative Group. Lower target blood pressures are safe and effective for the prevention of recurrent stroke: the PROGRESS trial. J Hypertens. 2006;24(6):1201–8. https://doi.org/10.1097/01.hjh.0000226212.34055.86. PMID: 16685221.

    Article  CAS  Google Scholar 

  18. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet. 2001;358(9287):1033–41. https://doi.org/10.1016/S0140-6736(01)06178-5. Erratum in: Lancet 2001 Nov 3;358(9292):1556. Erratum in: Lancet 2002 Jun 15;359(9323):2120.

    Article  Google Scholar 

  19. Healey JS, Baranchuk A, Crystal E, Morillo CA, Garfinkle M, Yusuf S, Connolly SJ. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol. 2005;45(11):1832–9. https://doi.org/10.1016/j.jacc.2004.11.070.

    Article  CAS  Google Scholar 

  20. Kalus JS, Coleman CI, White CM. The impact of suppressing the renin-angiotensin system on atrial fibrillation. J Clin Pharmacol. 2006;46(1):21–8. https://doi.org/10.1177/0091270005283284.

    Article  CAS  Google Scholar 

  21. Madrid AH, Bueno MG, Rebollo JM, Marín I, Peña G, Bernal E, Rodriguez A, Cano L, Cano JM, Cabeza P, Moro C. Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study. Circulation. 2002;106(3):331–6. https://doi.org/10.1161/01.cir.0000022665.18619.83.

    Article  CAS  Google Scholar 

  22. Nasr IA, Bouzamondo A, Hulot JS, Dubourg O, Le Heuzey JY, Lechat P. Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis. Eur Heart J. 2007;28(4):457–62. https://doi.org/10.1093/eurheartj/ehl484. Epub 2007 Feb 8.

    Article  CAS  Google Scholar 

  23. Schaer BA, Schneider C, Jick SS, Conen D, Osswald S, Meier CR. Risk for incident atrial fibrillation in patients who receive antihypertensive drugs: a nested case-control study. Ann Intern Med. 2010;152(2):78–84. https://doi.org/10.7326/0003-4819-152-2-201001190-00005.

    Article  Google Scholar 

  24. L'Allier PL, Ducharme A, Keller PF, Yu H, Guertin MC, Tardif JC. Angiotensin-converting enzyme inhibition in hypertensive patients is associated with a reduction in the occurrence of atrial fibrillation. J Am Coll Cardiol. 2004;44(1):159–64. https://doi.org/10.1016/j.jacc.2004.03.056.

    Article  CAS  Google Scholar 

  25. Oh GC, Cho HJ. Blood pressure and heart failure. Clin Hypertens. 2020;26:1. Published 2020 Jan 2. https://doi.org/10.1186/s40885-019-0132-x.

    Article  Google Scholar 

  26. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)developed with the special contribution of the heart failure association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200. https://doi.org/10.1093/eurheartj/ehw128.

    Article  Google Scholar 

  27. Tocci G, Sciarretta S, Volpe M. Development of heart failure in recent hypertension trials. J Hypertens. 2008;26(7):1477–86. https://doi.org/10.1097/HJH.0b013e3282fe1d3d.

    Article  CAS  Google Scholar 

  28. Vasan RS, Larson MG, Leip EP, Evans JC, O'Donnell CJ, Kannel WB, Levy D. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001;345(18):1291–7. https://doi.org/10.1056/NEJMoa003417.

    Article  CAS  Google Scholar 

  29. Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275(20):1557–62.

    Article  CAS  Google Scholar 

  30. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D’Agostino RB, Kannel WB, Murabito JM, Vasan RS, Benjamin EJ, Levy D, Framingham Heart Study. Lifetime risk for developing congestive heart failure: the Framingham heart study. Circulation. 2002;106(24):3068–72. https://doi.org/10.1161/01.cir.0000039105.49749.6f.

    Article  Google Scholar 

  31. de Boer IH, Bangalore S, Benetos A, Davis AM, Michos ED, Muntner P, Rossing P, Zoungas S, Bakris G. Diabetes and hypertension: a position statement by the American Diabetes Association. Diabetes Care. 2017;40(9):1273–84. https://doi.org/10.2337/dci17-0026.

    Article  CAS  Google Scholar 

  32. Messerli FH, Rimoldi SF, Bangalore S. The transition from hypertension to heart failure: contemporary update. JACC Heart Fail. 2017;5(8):543–51. https://doi.org/10.1016/j.jchf.2017.04.012. Epub 2017 Jul 12. Erratum in: JACC Heart Fail. 2017 Dec;5(12 ):948.

    Article  Google Scholar 

  33. Slivnick J, Lampert BC. Hypertension and heart failure. Heart Fail Clin. 2019;15(4):531–41. https://doi.org/10.1016/j.hfc.2019.06.007. Epub 2019 Jul 31.

    Article  Google Scholar 

  34. Sorrentino MJ. The evolution from hypertension to heart failure. Heart Fail Clin. 2019;15(4):447–53. https://doi.org/10.1016/j.hfc.2019.06.005. Epub 2019 Aug 7.

    Article  Google Scholar 

  35. Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med. 1994;330(20):1431–8. https://doi.org/10.1056/NEJM199405193302008.

    Article  CAS  Google Scholar 

  36. Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15(7):387–407. https://doi.org/10.1038/s41569-018-0007-y.

    Article  CAS  Google Scholar 

  37. Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011;58(17):1733–40. https://doi.org/10.1016/j.jacc.2011.07.022.

    Article  Google Scholar 

  38. de Simone G, Gottdiener JS, Chinali M, Maurer MS. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the cardiovascular health study. Eur Heart J. 2008;29(6):741–7. https://doi.org/10.1093/eurheartj/ehm605. Epub 2008 Jan 19.

    Article  Google Scholar 

  39. Sciarretta S, Paneni F, Palano F, Chin D, Tocci G, Rubattu S, Volpe M. Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction. Clin Sci (Lond). 2009;116(6):467–77. https://doi.org/10.1042/CS20080390.

    Article  CAS  Google Scholar 

  40. Wright JW, Mizutani S, Harding JW. Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies. Heart Fail Rev. 2008;13(3):367–75. https://doi.org/10.1007/s10741-007-9060-z. Epub 2007 Nov 7.

    Article  CAS  Google Scholar 

  41. Bhatia RS, Tu JV, Lee DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med. 2006;355:260–9.

    Article  CAS  Google Scholar 

  42. Gheorghiade M, Abraham WT, Albert NM, et al. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA. 2006;296(18):2217–26. https://doi.org/10.1001/jama.296.18.2217.

    Article  CAS  Google Scholar 

  43. Rouleau JL, Roecker EB, Tendera M, Mohacsi P, Krum H, Katus HA, Fowler MB, Coats AJ, Castaigne A, Scherhag A, Holcslaw TL, Packer M. Carvedilol prospective randomized cumulative survival study group. Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure: the carvedilol prospective randomized cumulative survival (COPERNICUS) study. J Am Coll Cardiol. 2004;43(8):1423–9. https://doi.org/10.1016/j.jacc.2003.11.037.

    Article  CAS  Google Scholar 

  44. Tsimploulis A, Lam PH, Arundel C, Singh SN, Morgan CJ, Faselis C, Deedwania P, Butler J, Aronow WS, Yancy CW, Fonarow GC, Ahmed A. Systolic blood pressure and outcomes in patients with heart failure with preserved ejection fraction. JAMA Cardiol. 2018;3(4):288–97. https://doi.org/10.1001/jamacardio.2017.5365. Erratum in: JAMA Cardiol 201;3(4):358. PMID: 29450487; PMCID: PMC5875342.

    Article  Google Scholar 

  45. Vidán MT, Bueno H, Wang Y, Schreiner G, Ross JS, Chen J, Krumholz HM. The relationship between systolic blood pressure on admission and mortality in older patients with heart failure. Eur J Heart Fail. 2010;12(2):148–55. https://doi.org/10.1093/eurjhf/hfp195. PMID: 20083624; PMCID: PMC2807767.

    Article  Google Scholar 

  46. Zhang Y, Wang C, Zhang J, Zhang H, Yin Z, Chen Y, Xie Q. Low systolic blood pressure for predicting all-cause mortality in patients hospitalised with heart failure: a systematic review and meta-analysis. Eur J Prev Cardiol. 2019;26(4):439–43. https://doi.org/10.1177/2047487318784092. Epub 2018 Jun 25.

    Article  Google Scholar 

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Authors and Affiliations

  1. Cardiology Department, Asklepeion General Hospital, Athens, Greece

    N. Papaioannou

  2. 2nd Department of Cardiology, Metropolitan Hospital, Athens, Greece

    M. S. Kallistratos, T. Zamfir & A. J. Manolis

Authors
  1. N. Papaioannou
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  2. M. S. Kallistratos
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  3. T. Zamfir
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  4. A. J. Manolis
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Corresponding author

Correspondence to M. S. Kallistratos .

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Editors and Affiliations

  1. Carol Davila University of Medicine and Pharmacy, Bucharest, Bucuresti, Romania

    Maria Dorobantu

  2. Department of Pharmacology, Toxicology and Clinical Psychopharmacology Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Victor Voicu

  3. University of Milano-Bicocca, Milano, Italy

    Guido Grassi

  4. Dept of Clinical and Experimental Sci, University of Brescia, Brescia, Italy

    Enrico Agabiti-Rosei

  5. University of Milano-Bicocca, Milano, Italy

    Giuseppe Mancia

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Papaioannou, N., Kallistratos, M.S., Zamfir, T., Manolis, A.J. (2023). Atrial Fibrillation, Hypertension, and Heart Failure. In: Dorobantu, M., Voicu, V., Grassi, G., Agabiti-Rosei, E., Mancia, G. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-031-39315-0_19

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