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New Perspectives on Cardiac Magnetic Resonance Imaging in Hypertensive Patients with Heart Failure

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Hypertension and Heart Failure

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

This chapter presents an overview of the role of cardiovascular magnetic resonance (CMR) imaging in the assessment of hypertensive heart disease (HHD). HHD refers to structural and functional changes in the heart due to arterial hypertension. CMR offers high-resolution imaging and is considered the gold standard for measuring the cardiac chamber’s dimensions and function. It can identify left ventricular hypertrophy (LVH), diastolic dysfunction, myocardial fibrosis, and left atrial dilation. CMR imaging aids in differentiating HHD from other causes of LVH, such as hypertrophic cardiomyopathy, athlete heart, and cardiac amyloidosis (CA). Specific CMR patterns, including late gadolinium enhancement (LGE) and native T1 and T2 mapping, can help identify these conditions. Furthermore, CMR can be valuable in assessing myocardial alterations in uremic cardiomyopathy, a subtype of HHD associated with chronic kidney disease. Although echocardiography remains the mainstay of diastolic function assessment, CMR offers additional information and a potential prognostic value. Overall, CMR plays a crucial role in identifying and characterizing cardiac structural and functional abnormalities in HHD, contributing to improved patient management and outcomes.

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References

  1. Tadic M, Cuspidi C, Plein S, Milivojevic IG, Wang DW, Grassi G, et al. Comprehensive assessment of hypertensive heart disease: cardiac magnetic resonance in focus. Heart Fail Rev. 2020;26(6):1383–90.

    Article  Google Scholar 

  2. Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens. 1998;16(7):1031. Available from https://journals.lww.com/jhypertension/Fulltext/1998/16070/Pathologic_fibrosis_and_connective_tissue_matrix.18.aspx.

    Article  CAS  Google Scholar 

  3. Rudolph A, Abdel-Aty H, Bohl S, Boyé P, Zagrosek A, Dietz R, et al. Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol. 2009;53:284.

    Article  Google Scholar 

  4. Tahir E, Starekova J, Muellerleile K, von Stritzky A, Münch J, Avanesov M, et al. Myocardial fibrosis in competitive triathletes detected by contrast-enhanced CMR correlates with exercise-induced hypertension and competition history. JACC Cardiovasc Imaging. 2018;11(9):1260–70. Available from https://www.sciencedirect.com/science/article/pii/S1936878X17309816.

    Article  Google Scholar 

  5. Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S. Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson. 2016;18(1):89. https://doi.org/10.1186/s12968-016-0308-4.

    Article  Google Scholar 

  6. Kuruvilla S, Janardhanan R, Antkowiak P, Keeley EC, Adenaw N, Brooks J, et al. Increased extracellular volume and altered mechanics are associated with LVH in hypertensive heart disease, not hypertension alone. JACC Cardiovasc Imaging. 2015;8(2):172–80.

    Article  Google Scholar 

  7. Treibel TA, Zemrak F, Sado DM, Banypersad SM, White SK, Maestrini V, et al. Extracellular volume quantification in isolated hypertension - changes at the detectable limits? J Cardiovasc Magn Reson. 2015;17(1):74. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534050/.

    Article  Google Scholar 

  8. Rodrigues JCL, Amadu AM, Ghosh Dastidar A, McIntyre B, Szantho GV, Lyen S, et al. ECG strain pattern in hypertension is associated with myocardial cellular expansion and diffuse interstitial fibrosis: a multi-parametric cardiac magnetic resonance study. Eur Heart J Cardiovasc Imaging. 2017;18(4):441–50. https://doi.org/10.1093/ehjci/jew117.

    Article  Google Scholar 

  9. Schillaci G, Pasqualini L, Verdecchia P, Vaudo G, Marchesi S, Porcellati C, et al. Prognostic significance of left ventricular diastolic dysfunction in essential hypertension. J Am Coll Cardiol. 2002;39(12):2005–11. Available from https://www.sciencedirect.com/science/article/pii/S073510970201896X.

    Article  Google Scholar 

  10. Chamsi-Pasha MA, Zhan Y, Debs D, Shah DJ. CMR in the evaluation of diastolic dysfunction and phenotyping of HFpEF: current role and future perspectives. JACC Cardiovasc Imaging. 2020;13(1):283–96. Available from https://www.sciencedirect.com/science/article/pii/S1936878X19303730.

    Article  Google Scholar 

  11. Garg P, Gosling R, Swoboda P, Jones R, Rothman A, Wild JM, et al. Cardiac magnetic resonance identifies raised left ventricular filling pressure: prognostic implications. Eur Heart J. 2022;43(26):2511–22. https://doi.org/10.1093/eurheartj/ehac207.

    Article  Google Scholar 

  12. Giusca S, Steen H, Montenbruck M, Patel AR, Pieske B, Erley J, et al. Multi-parametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2021;23(1):92. https://doi.org/10.1186/s12968-021-00775-8.

    Article  Google Scholar 

  13. Schuster A, Hor KN, Kowallick JT, Beerbaum P, Kutty S. Cardiovascular magnetic resonance myocardial feature tracking. Circ Cardiovasc Imaging. 2016;9(4):e004077. https://doi.org/10.1161/CIRCIMAGING.115.004077.

    Article  Google Scholar 

  14. Lange T, Schuster A. Quantification of myocardial deformation applying CMR-feature-tracking—all about the left ventricle? Curr Heart Fail Rep. 2021;18(4):225–39. https://doi.org/10.1007/s11897-021-00515-0.

    Article  Google Scholar 

  15. Song Y, Li L, Chen X, Shao X, Lu M, Cheng J, et al. Early left ventricular diastolic dysfunction and abnormal left ventricular-left atrial coupling in asymptomatic patients with hypertension: a cardiovascular magnetic resonance feature tracking study. J Thorac Imaging. 2022;37(1):26. Available from https://journals.lww.com/thoracicimaging/Fulltext/2022/01000/Early_Left_Ventricular_Diastolic_Dysfunction_and.4.aspx.

    Article  Google Scholar 

  16. Neisius U, Myerson L, Fahmy AS, Nakamori S, El-Rewaidy H, Joshi G, et al. Cardiovascular magnetic resonance feature tracking strain analysis for discrimination between hypertensive heart disease and hypertrophic cardiomyopathy. PLoS One. 2019;14(8):e0221061. https://doi.org/10.1371/journal.pone.0221061.

    Article  CAS  Google Scholar 

  17. Shao G, Cao Y, Cui Y, Han X, Liu J, Li Y, et al. Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function. BMC Cardiovasc Disord. 2020;20(1):196. https://doi.org/10.1186/s12872-020-01469-2.

    Article  CAS  Google Scholar 

  18. Lavall D, Vosshage NH, Stoebe S, Denecke T, Hagendorff A, Laufs U. Native T1 mapping for differential diagnosis of left ventricular hypertrophy. Eur Heart J Cardiovasc Imaging. 2021;22(2):54. https://doi.org/10.1093/ehjci/jeab090.054.

    Article  Google Scholar 

  19. Hinojar R, Varma N, Child N, Goodman B, Jabbour A, Yu C-Y, et al. T1 mapping in discrimination of hypertrophic phenotypes: hypertensive heart disease and hypertrophic cardiomyopathy. Circ Cardiovasc Imaging. 2015;8(12):e003285. https://doi.org/10.1161/CIRCIMAGING.115.003285.

    Article  Google Scholar 

  20. Yilmaz A. The “Native T1 versus extracellular volume fraction paradox” in cardiac amyloidosis: answer to the million-dollar question? JACC Cardiovasc Imaging. 2019;12(5):820–2. Available from https://www.sciencedirect.com/science/article/pii/S1936878X18309264.

    Article  Google Scholar 

  21. Andrea B, Michele B, Ana M-N, Tushar K, Aviva P, Tamer R, et al. Noncontrast magnetic resonance for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging. 2020;13(1):69–80. https://doi.org/10.1016/j.jcmg.2019.03.026.

    Article  Google Scholar 

  22. Arcari L, Hinojar R, Carr-White G, Zainal H, Zhou H, Vasques M, et al. Excess of myocardial water and fibrosis define myocardial hypertrophy in uremic but not in hypertrophic cardiomyopathy - TrueTypeCKD study. Eur Heart J Cardiovasc Imaging. 2019;20(2):jez111.002. https://doi.org/10.1093/ehjci/jez111.002.

    Article  Google Scholar 

  23. Arcari L, Hinojar R, Engel J, Freiwald T, Platschek S, Zainal H, et al. Native T1 and T2 provide distinctive signatures in hypertrophic cardiac conditions – comparison of uremic, hypertensive and hypertrophic cardiomyopathy. Int J Cardiol. 2020;306:102–8. Available from: https://www.sciencedirect.com/science/article/pii/S0167527319347539.

    Article  Google Scholar 

  24. Kotecha T, Martinez-Naharro A, Yoowannakul S, Lambe T, Rezk T, Knight DS, et al. Acute changes in cardiac structural and tissue characterisation parameters following haemodialysis measured using cardiovascular magnetic resonance. Sci Rep. 2019;9(1):1388. https://doi.org/10.1038/s41598-018-37845-4.

    Article  CAS  Google Scholar 

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Onciul, S. (2023). New Perspectives on Cardiac Magnetic Resonance Imaging in Hypertensive Patients with Heart Failure. In: Dorobantu, M., Voicu, V., Grassi, G., Agabiti-Rosei, E., Mancia, G. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-031-39315-0_16

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  • DOI: https://doi.org/10.1007/978-3-031-39315-0_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-39314-3

  • Online ISBN: 978-3-031-39315-0

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