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Supportive Care Challenges and Management in Pancreatic Cancer

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Pancreatic Cancer

Abstract

Pancreatic cancer presents with complicated symptoms that require management alongside cancer treatments to improve patient’s quality of life during treatment. Pain in pancreatic cancer is frequently present as the first sign of disease; its etiology is multifactorial, consisting of pancreatic enzyme insufficiency, neuropathic pain, inflammation, obstruction, and direct mass effect from the tumor. Proper pain management is crucial in the overall management of these patients. Non-steroidal anti-inflammatories and acetaminophen are typically used as first-line therapy, followed by opioids and other treatments reviewed here, including disease-specific treatment with chemotherapy and radiation to manage pain by reducing obstruction and decreasing inflammation. Nerve blocks, high-intensity focused ultrasound, and other integrative measures with supplements and acupuncture have also been studied to treat pain in pancreatic cancer. The implementation of these measures may improve the quality of life of these patients.

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References

  1. Westermann MLA, Rahib L. The need for improvement in the management of fatigue, depression and pain in pancreatic cancer. J Clin Oncol. 2019;37(suppl 4):429.

    Article  Google Scholar 

  2. Hameed M, Hameed H, Erdek M. Pain management in pancreatic cancer. Cancers (Basel). 2010;3:43–60.

    Article  PubMed  Google Scholar 

  3. Coveler AL, Mizrahi J, Eastman B, Apisarnthanarax SJ, Dalal S, McNearney T, Pant S, Precision Promise C. Pancreas cancer-associated pain management. Oncologist. 2021;26:e971–82.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Demir IE, Schorn S, Schremmer-Danninger E, Wang K, Kehl T, Giese NA, Algul H, Friess H, Ceyhan GO. Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. PLoS One. 2013;8:e60529.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Yi SQ, Miwa K, Ohta T, Kayahara M, Kitagawa H, Tanaka A, Shimokawa T, Akita K, Tanaka S. Innervation of the pancreas from the perspective of perineural invasion of pancreatic cancer. Pancreas. 2003;27:225–9.

    Article  PubMed  Google Scholar 

  6. Barreto SG, Saccone GT. Pancreatic nociception—revisiting the physiology and pathophysiology. Pancreatology. 2012;12:104–12.

    Article  CAS  PubMed  Google Scholar 

  7. Ceyhan GO, Bergmann F, Kadihasanoglu M, Altintas B, Demir IE, Hinz U, Muller MW, Giese T, Buchler MW, Giese NA, Friess H. Pancreatic neuropathy and neuropathic pain—a comprehensive pathomorphological study of 546 cases. Gastroenterology. 2009;136:177–186 e1.

    Article  PubMed  Google Scholar 

  8. Zhu Z, Kleeff J, Kayed H, Wang L, Korc M, Buchler MW, Friess H. Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells. Mol Carcinog. 2002;35:138–47.

    Article  CAS  PubMed  Google Scholar 

  9. Koulouris AI, Banim P, Hart AR. Pain in patients with pancreatic cancer: prevalence, mechanisms, management and future developments. Dig Dis Sci. 2017;62:861–70.

    Article  CAS  PubMed  Google Scholar 

  10. Warshaw AL, Banks PA, Fernandez-Del Castillo C. AGA technical review: treatment of pain in chronic pancreatitis. Gastroenterology. 1998;115:765–76.

    Article  CAS  PubMed  Google Scholar 

  11. Costamagna G, Alevras P, Palladino F, Rainoldi F, Mutignani M, Morganti A. Endoscopic pancreatic stenting in pancreatic cancer. Can J Gastroenterol. 1999;13:481–7.

    Article  CAS  PubMed  Google Scholar 

  12. Wehrmann T, Riphaus A, Frenz MB, Martchenko K, Stergiou N. Endoscopic pancreatic duct stenting for relief of pancreatic cancer pain. Eur J Gastroenterol Hepatol. 2005;17:1395–400.

    Article  PubMed  Google Scholar 

  13. Whitcomb DC, Lehman GA, Vasileva G, Malecka-Panas E, Gubergrits N, Shen Y, Sander-Struckmeier S, Caras S. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: a double-blind randomized trial. Am J Gastroenterol. 2010;105:2276–86.

    Article  CAS  PubMed  Google Scholar 

  14. Trapnell BC, Maguiness K, Graff GR, Boyd D, Beckmann K, Caras S. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2009;8:370–7.

    Article  CAS  PubMed  Google Scholar 

  15. Gubergrits N, Malecka-Panas E, Lehman GA, Vasileva G, Shen Y, Sander-Struckmeier S, Caras S, Whitcomb DC. A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery. Aliment Pharmacol Ther. 2011;33:1152–61.

    Article  CAS  PubMed  Google Scholar 

  16. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231:232–5.

    Article  CAS  PubMed  Google Scholar 

  17. Smith HS. Potential analgesic mechanisms of acetaminophen. Pain Physician. 2009;12:269–80.

    Article  PubMed  Google Scholar 

  18. Morrone LA, Scuteri D, Rombola L, Mizoguchi H, Bagetta G. Opioids resistance in chronic pain management. Curr Neuropharmacol. 2017;15:444–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Schmidt-Hansen M, Bromham N, Taubert M, Arnold S, Hilgart JS. Buprenorphine for treating cancer pain. Cochrane Database Syst Rev. 2015;2018:CD009596.

    Google Scholar 

  20. Perez-Hernandez C, Blasco A, Gandara A, Manas A, Rodriguez-Lopez MJ, Martinez V, Fernandez-Nistal A, Montoto C. Prevalence and characterization of breakthrough pain in patients with cancer in Spain: the CARPE-DIO study. Sci Rep. 2019;9:17701.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Nersesyan H, Slavin KV. Current aproach to cancer pain management: availability and implications of different treatment options. Ther Clin Risk Manag. 2007;3:381–400.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Carmichael AN, Morgan L, Del Fabbro E. Identifying and assessing the risk of opioid abuse in patients with cancer: an integrative review. Subst Abus Rehabil. 2016;7:71–9.

    Google Scholar 

  23. Dalal S, Bruera E. Pain management for patients with advanced cancer in the opioid epidemic era. Am Soc Clin Oncol Educ Book. 2019;39:24–35.

    Article  PubMed  Google Scholar 

  24. Turk DC, Swanson KS, Gatchel RJ. Predicting opioid misuse by chronic pain patients: a systematic review and literature synthesis. Clin J Pain. 2008;24:497–508.

    Article  PubMed  Google Scholar 

  25. Edlund MJ, Martin BC, Fan MY, Devries A, Braden JB, Sullivan MD. Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. Drug Alcohol Depend. 2010;112:90–8.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Carvajal G, Dupoiron D, Seegers V, Lebrec N, Bore F, Dubois PY, Leblanc D, Delorme T, Jubier-Hamon S. Intrathecal drug delivery systems for refractory pancreatic cancer pain: observational follow-up study over an 11-year period in a comprehensive cancer center. Anesth Analg. 2018;126:2038–46.

    Article  CAS  PubMed  Google Scholar 

  27. Dupoiron D. Intrathecal therapy for pain in cancer patients. Curr Opin Support Palliat Care. 2019;13:75–80.

    Article  PubMed  Google Scholar 

  28. Dupoiron D, Leblanc D, Demelliez-Merceron S, Bore F, Seegers V, Dubois PY, Pechard M, Robard S, Delorme T, Jubier-Hamon S, Carvajal G, Lebrec N. Optimizing initial intrathecal drug ratio for refractory cancer-related pain for early pain relief. A retrospective monocentric study. Pain Med. 2019;20:2033–42.

    Article  PubMed  Google Scholar 

  29. Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, Buchser E, Catala E, Bryce DA, Coyne PJ, Pool GE, et al. Implantable drug delivery systems study, randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2002;20:4040–9.

    Article  CAS  PubMed  Google Scholar 

  30. Wang-Gillam A, Li CP, Bodoky G, Dean A, Shan YS, Jameson G, Macarulla T, Lee KH, Cunningham D, Blanc JF, Hubner RA, Chiu CF, Schwartsmann G, Siveke JT, Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen LT, N.-S. Group. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016;387:545–57.

    Article  CAS  PubMed  Google Scholar 

  31. Gourgou-Bourgade S, Bascoul-Mollevi C, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Boige V, Berille J, Conroy T. Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial. J Clin Oncol. 2013;31:23–9.

    Article  CAS  PubMed  Google Scholar 

  32. Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, Von Hoff DD. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403–13.

    Article  CAS  PubMed  Google Scholar 

  33. Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, Turriziani A, Cellini N. Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas. J Palliat Care. 2003;19:258–62.

    Article  PubMed  Google Scholar 

  34. Ebrahimi G, Rasch CRN, van Tienhoven G. Pain relief after a short course of palliative radiotherapy in pancreatic cancer, the Academic Medical Center (AMC) experience. Acta Oncol. 2018;57:697–700.

    Article  PubMed  Google Scholar 

  35. Ryan JF, Rosati LM, Groot VP, Le DT, Zheng L, Laheru DA, Shin EJ, Jackson J, Moore J, Narang AK, Herman JM. Stereotactic body radiation therapy for palliative management of pancreatic adenocarcinoma in elderly and medically inoperable patients. Oncotarget. 2018;9:16427–36.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Buwenge M, Macchia G, Arcelli A, Frakulli R, Fuccio L, Guerri S, Grassi E, Cammelli S, Cellini F, Morganti AG. Stereotactic radiotherapy of pancreatic cancer: a systematic review on pain relief. J Pain Res. 2018;11:2169–78.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Costamagna G, Pandolfi M. Endoscopic stenting for biliary and pancreatic malignancies. J Clin Gastroenterol. 2004;38:59–67.

    Article  PubMed  Google Scholar 

  38. Maloney E, Hwang JH. Emerging HIFU applications in cancer therapy. Int J Hyperth. 2015;31:302–9.

    Article  Google Scholar 

  39. Zhou Y. High-intensity focused ultrasound treatment for advanced pancreatic cancer. Gastroenterol Res Pract. 2014;2014:205325.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Xiong LL, Hwang JH, Huang XB, Yao SS, He CJ, Ge XH, Ge HY, Wang XF. Early clinical experience using high intensity focused ultrasound for palliation of inoperable pancreatic cancer. JOP. 2009;10:123–9.

    PubMed  Google Scholar 

  41. Zhang CL, Zhang TJ, Guo YN, Yang LQ, He MW, Shi JZ, Ni JX. Effect of neurolytic celiac plexus block guided by computerized tomography on pancreatic cancer pain. Dig Dis Sci. 2008;53:856–60.

    Article  PubMed  Google Scholar 

  42. Wong GY, Schroeder DR, Carns PE, Wilson JL, Martin DP, Kinney MO, Mantilla CB, Warner DO. Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial. JAMA. 2004;291:1092–9.

    Article  CAS  PubMed  Google Scholar 

  43. Mercadante S. Celiac plexus block versus analgesics in pancreatic cancer pain. Pain. 1993;52:187–92.

    Article  PubMed  Google Scholar 

  44. Arcidiacono PG, Calori G, Carrara S, McNicol ED, Testoni PA. Celiac plexus block for pancreatic cancer pain in adults. Cochrane Database Syst Rev. 2011;2019:CD007519.

    Google Scholar 

  45. Nagels W, Pease N, Bekkering G, Cools F, Dobbels P. Celiac plexus neurolysis for abdominal cancer pain: a systematic review. Pain Med. 2013;14:1140–63.

    Article  PubMed  Google Scholar 

  46. Zhong W, Yu Z, Zeng JX, Lin Y, Yu T, Min XH, Yuan YH, Chen QK. Celiac plexus block for treatment of pain associated with pancreatic cancer: a meta-analysis. Pain Pract. 2014;14:43–51.

    Article  PubMed  Google Scholar 

  47. Cornman-Homonoff J, Holzwanger DJ, Lee KS, Madoff DC, Li D. Celiac plexus block and neurolysis in the management of chronic upper abdominal pain. Semin Intervent Radiol. 2017;34:376–86.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Zhou X, Li CG, Chang D, Bensoussan A. Current status and major challenges to the safety and efficacy presented by Chinese herbal medicine. Medicines (Basel). 2019;6:14.

    Article  CAS  PubMed  Google Scholar 

  49. Jermini M, Dubois J, Rodondi PY, Zaman K, Buclin T, Csajka C, Orcurto A, et al. Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic Centre. Sci Rep. 2019;9:5078.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Guindon J, Hohmann AG. The endocannabinoid system and pain. CNS Neurol Disord Drug Targets. 2009;8:403–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Starowicz FDK. Cannabinoids and pain: sites and mechanisms of action. New York: Elsevier; 2017.

    Google Scholar 

  52. Abrams DI. Integrating cannabis into clinical cancer care. Curr Oncol. 2016;23:S8–S14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Lau CHY, Wu X, Chung VCH, Liu X, Hui EP, Cramer H, Lauche R, Wong SYS, Lau AYL, Sit RWS, Ziea ETC, Ng BFL, Wu JCY. Acupuncture and related therapies for symptom management in palliative cancer care: systematic review and meta-analysis. Medicine (Baltimore). 2016;95:e2901.

    Article  PubMed  Google Scholar 

  54. Lee IS, Cheon S, Park JY. Central and peripheral mechanism of acupuncture analgesia on visceral pain: a systematic review. Evid Based Complement Alternat Med. 2019;2019:1304152.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Shalini Dalal .

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Tschanz, J., Sanchez, E.H., Dalal, S. (2023). Supportive Care Challenges and Management in Pancreatic Cancer. In: Pant, S. (eds) Pancreatic Cancer. Springer, Cham. https://doi.org/10.1007/978-3-031-38623-7_8

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  • DOI: https://doi.org/10.1007/978-3-031-38623-7_8

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