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Response, Complications, Safety, Supervision, and Quality Indicators for NIMV Outside ICU. Risk Factors for Failure

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Noninvasive Ventilation Outside Intensive Care Unit

Part of the book series: Noninvasive Ventilation. The Essentials ((NVE))

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Abstract

Noninvasive respiratory therapies have experienced significant growth in recent years, especially positive airway pressure or high-flow oxygen therapy. The usefulness of this respiratory support has been demonstrated in chronic obstructive pulmonary disease exacerbation, obesity hypoventilation syndrome, acute pulmonary edema, or acute hypoxemic respiratory failure due to infectious pneumonia. However, the failure of these therapies may increase mortality due to delayed invasive mechanical ventilation; therefore, it is essential to identify risk factors for failure.

Briefly, persistence of high respiratory rate, poor improvement in gas exchange, severity assessed by scales such as SAPS II, HACOR, or low ROX index, and presence of comorbidities or intolerance to the device are presented as predictors of failure of noninvasive respiratory therapies.

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References

  1. Osadnik CR, Tee VS, Carson-Chahhoud KV, Picot J, Wedzicha JA, Smith BJ. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017;2017(7):CD004104.

    PubMed Central  Google Scholar 

  2. Masa JF, Pépin JL, Borel JC, Mokhlesi B, Murphy PB, Sánchez-Quiroga MÁ. Obesity hypoventilation syndrome. Eur Respir Rev. 2019;28(151):180097.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Masip J, Peacock WF, Price S, Cullen L, Martin-Sanchez FJ, Seferovic P, et al. Indications and practical approach to non-invasive ventilation in acute heart failure. Eur Heart J. 2018;39(1):17–25.

    Article  PubMed  Google Scholar 

  4. Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, et al. Effect of noninvasive respiratory strategies on intubation or mortality among patients with acute hypoxemic respiratory failure and COVID-19: the RECOVERY-RS randomized clinical trial. JAMA. 2022;327(6):546.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372(23):2185–96.

    Article  CAS  PubMed  Google Scholar 

  6. Ozyilmaz E, Ugurlu AO, Nava S. Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies. BMC Pulm Med. 2014;14(1):19.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nava S, Hill N. Non-invasive ventilation in acute respiratory failure. Lancet. 2009;374(9685):250–9.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Scala R. Respiratory high-dependency care units for the burden of acute respiratory failure. Eur J Intern Med. 2012;23(4):302–8.

    Article  PubMed  Google Scholar 

  9. Mosier JM, Sakles JC, Whitmore SP, Hypes CD, Hallett DK, Hawbaker KE, et al. Failed noninvasive positive-pressure ventilation is associated with an increased risk of intubation-related complications. Ann Intensive Care. 2015;5(1):4.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hraiech S, Alingrin J, Dizier S, Brunet J, Forel JM, La Scola B, et al. Time to intubation is associated with outcome in patients with community-acquired pneumonia. PLoS One. 2013;8(9):e74937.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Long B, Liang SY, Lentz S. High flow nasal cannula for adult acute hypoxemic respiratory failure in the ED setting. Am J Emerg Med. 2021;49:352–9.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Oczkowski S, Ergan B, Bos L, Chatwin M, Ferrer M, Gregoretti C, et al. ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure. Eur Respir J. 2022;59(4):2101574.

    Article  PubMed  Google Scholar 

  13. Rochwerg B, Einav S, Chaudhuri D, Mancebo J, Mauri T, Helviz Y, et al. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020;46:1–12.

    Article  Google Scholar 

  14. Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, et al. Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: the utility of the ROX index. J Crit Care. 2016;35:200–5.

    Article  PubMed  Google Scholar 

  15. Masclans JR, Roca O. High-flow oxygen therapy in acute respiratory failure. Clin Pulm Med. 2012;19(3):127–30.

    Article  Google Scholar 

  16. Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, et al. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med. 2011;37(11):1780–6.

    Article  CAS  PubMed  Google Scholar 

  17. Kim BK, Kim S, Kim CY, Cha J, Lee YS, Ko Y, et al. Factors associated with failure of high-flow nasal cannula. Respir Care. 2020;65(9):1276–84.

    Article  PubMed  Google Scholar 

  18. Roca O, de Acilu MG, Caralt B, Sacanell J, Masclans JR. Humidified high flow nasal cannula supportive therapy improves outcomes in lung transplant recipients readmitted to the intensive care unit because of acute respiratory failure. Transplantation. 2015;99(5):1092–8.

    Article  PubMed  Google Scholar 

  19. Frat JP, Ragot S, Coudroy R, Constantin JM, Girault C, Prat G, et al. Predictors of intubation in patients with acute hypoxemic respiratory failure treated with a noninvasive oxygenation strategy. Crit Care Med. 2018;46(2):208–15.

    Article  PubMed  Google Scholar 

  20. Messika J, Ben Ahmed K, Gaudry S, Miguel-Montanes R, Rafat C, Sztrymf B, et al. Use of high-flow nasal cannula oxygen therapy in subjects with ARDS: a 1-year observational study. Respir Care. 2015;60(2):162–9.

    Article  PubMed  Google Scholar 

  21. Garner O, Dongarwar D, Salihu HM, Barrantes Perez JH, Abraham J, McBride C, et al. Predictors of failure of high flow nasal cannula failure in acute hypoxemic respiratory failure due to COVID-19. Respir Med. 2021;185:106474.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Valencia CF, Lucero OD, Castro OC, Sanko AA, Olejua PA. Comparison of ROX and HACOR scales to predict high-flow nasal cannula failure in patients with SARS-CoV-2 pneumonia. Sci Rep. 2021;11:22559.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Magdy DM, Metwally A. The utility of HACOR score in predicting failure of high-flow nasal oxygen in acute hypoxemic respiratory failure. Adv Respir Med. 2021;89(1):23–9.

    Article  PubMed  Google Scholar 

  24. Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med. 2019;199(11):1368–76.

    Article  PubMed  Google Scholar 

  25. Chen W, Janz DR, Shaver CM, Bernard GR, Bastarache JA, Ware LB. Clinical characteristics and outcomes are similar in ARDS diagnosed by oxygen saturation/Fio2 ratio compared with Pao2/Fio2 ratio. Chest. 2015;148(6):1477–83.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Fink DL, Goldman NR, Cai J, El-Shakankery KH, Sismey GE, Gupta-Wright A, et al. Ratio of oxygen saturation index to guide management of COVID-19 pneumonia. Ann Am Thorac Soc. 2021;18(8):1426–8.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Prakash J, Bhattacharya PK, Yadav AK, Kumar A, Tudu LC, Prasad K. ROX index as a good predictor of high flow nasal cannula failure in COVID-19 patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis. J Crit Care. 2021;66:102–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Kang BJ, Koh Y, Lim CM, Huh JW, Baek S, Han M, et al. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med. 2015;41(4):623–32.

    Article  PubMed  Google Scholar 

  29. Chandel A, Patolia S, Brown AW, Collins AC, Sahjwani D, Khangoora V, et al. High-flow nasal cannula therapy in COVID-19: using the ROX Index to predict success. Respir Care. 2021;66(6):909–19.

    Article  PubMed  Google Scholar 

  30. Rana S, Jenad H, Gay PC, Buck CF, Hubmayr RD, Gajic O. Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study. Crit Care. 2006;10(3):R79.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Antonelli M, Conti G, Moro M, Esquinas A, Gonzalez-Diaz G, Confalonieri M, et al. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med. 2001;27(11):1718–28.

    Article  CAS  PubMed  Google Scholar 

  32. Conti G, Antonelli M, Navalesi P, Rocco M, Bufi M, Spadetta G, et al. Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial. Intensive Care Med. 2002;28(12):1701–7.

    Article  CAS  PubMed  Google Scholar 

  33. Confalonieri M. A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation. Eur Respir J. 2005;25(2):348–55.

    Article  CAS  PubMed  Google Scholar 

  34. The ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012;307(23):2526. https://doi.org/10.1001/jama.2012.5669.

    Article  CAS  Google Scholar 

  35. Thille AW, Contou D, Fragnoli C, Córdoba-Izquierdo A, Boissier F, Brun-Buisson C. Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. Crit Care. 2013;17(6):R269.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, et al. Noninvasive ventilation of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE study. Am J Respir Crit Care Med. 2017;195(1):67–77.

    Article  PubMed  Google Scholar 

  37. Shu W, Guo S, Yang F, Liu B, Zhang Z, Liu X, et al. Association between ARDS etiology and risk of noninvasive ventilation failure. Ann Am Thorac Soc. 2022;19(2):255–63.

    Article  PubMed  Google Scholar 

  38. Duan J, Wang S, Liu P, Han X, Tian Y, Gao F, et al. Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score. Ann Intensive Care. 2019;9(1):108.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Nicolini A, Ferrera L, Santo M, Ferrari-Bravo M, Del Forno M, Sclifò F. Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure. Pol Arch Intern Med. 2014;124(10):525–31.

    Article  Google Scholar 

  40. Duan J, Han X, Bai L, Zhou L, Huang S. Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients. Intensive Care Med. 2017;43(2):192–9.

    Article  CAS  PubMed  Google Scholar 

  41. Ferrer M, Ioanas M, Arancibia F, Marco MA, de la Bellacasa JP, Torres A. Microbial airway colonization is associated with noninvasive ventilation failure in exacerbation of chronic obstructive pulmonary disease*. Crit Care Med. 2005;33(9):2003–9.

    Article  PubMed  Google Scholar 

  42. Nicolini A, Lemyze M, Esquinas A, Barlascini C, Cavalleri MA. Predictors of noninvasive ventilation failure in critically ill obese patients: a brief narrative review. Adv Respir Med. 2017;85(5):264–70.

    Article  PubMed  Google Scholar 

  43. Vital FM, Ladeira MT, Atallah ÁN. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev. 2013;(5):CD005351. https://doi.org/10.1002/14651858.CD005351.pub3.

  44. Luo Z, Han F, Li Y, He H, Yang G, Mi Y, et al. Risk factors for noninvasive ventilation failure in patients with acute cardiogenic pulmonary edema: a prospective, observational cohort study. J Crit Care. 2017;39:238–47.

    Article  PubMed  Google Scholar 

  45. Carrillo-Aleman L, Carrasco-Gónzalez E, Araújo MJ, Guia M, Alonso-Fernández N, Renedo-Villarroya A, et al. Is hypocapnia a risk factor for non-invasive ventilation failure in cardiogenic acute pulmonary edema? J Crit Care. 2022;69:153991.

    Article  PubMed  Google Scholar 

  46. Carrillo A, Gonzalez-Diaz G, Ferrer M, Martinez-Quintana ME, Lopez-Martinez A, Llamas N, et al. Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med. 2012;38(3):458–66.

    Article  PubMed  Google Scholar 

  47. Nicolini A, Grazia IM, Barlascini C. Predictors of non-invasive ventilation failure in severe respiratory failure due to community acquired pneumonia. Tanaffos. 2014;13(4):20–8.

    PubMed  PubMed Central  Google Scholar 

  48. Shneerson JM, Simonds AK. Noninvasive ventilation for chest wall and neuromuscular disorders. Eur Respir J. 2002;20(2):480–7.

    Article  CAS  PubMed  Google Scholar 

  49. Toussaint M, Chatwin M, Soudon P. Review Article: Mechanical ventilation in Duchenne patients with chronic respiratory insufficiency: clinical implications of 20 years published experience. Chron Respir Dis. 2007;4(3):167–77.

    Article  CAS  PubMed  Google Scholar 

  50. Martí S, Pallero M, Ferrer J, Ríos J, Rodríguez E, Morell F, et al. Predictors of mortality in chest wall disease treated with noninvasive home mechanical ventilation. Respir Med. 2010;104(12):1843–9.

    Article  PubMed  Google Scholar 

  51. Ueno Y, Nakanishi N, Oto J, Imanaka H, Nishimura M. A bench study of the effects of leak on ventilator performance during noninvasive ventilation. Respir Care. 2011;56(11):1758–64.

    Article  PubMed  Google Scholar 

  52. Cabrini L, Landoni G, Zangrillo A. Noninvasive ventilation failure: the answer is blowing in the leaks. Respir Care. 2011;56(11):1857–8.

    Article  PubMed  Google Scholar 

  53. Carteaux G, Millán-Guilarte T, De Prost N, Razazi K, Abid S, Thille AW, et al. Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume*. Crit Care Med. 2016;44(2):282–90.

    Article  PubMed  Google Scholar 

  54. Kumar A, Sinha C, Kumar A, Kumar N, Kumar A, Singh K, et al. Inefficient humidification as the cause of noninvasive ventilation failure in COVID-19 patients. Braz J Anesthesiol Engl Ed. 2021;71(6):671–2.

    Google Scholar 

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Authors and Affiliations

  1. Intermediate Respiratory Care Unit, Department of Pneumology, Nurse Isabel Zendal Emergency Hospital, Madrid, Madrid, Spain

    José Terán-Tinedo, María Churruca Arróspide, Miguel Lorente, Miguel Suarez & Pedro Landete

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  1. José Terán-Tinedo
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  2. María Churruca Arróspide
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  3. Miguel Lorente
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  4. Miguel Suarez
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  5. Pedro Landete
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Editor information

Editors and Affiliations

  1. Intensive Care Unit, Hospital General Universitario Morales M, Murcia, Murcia, Spain

    Antonio M. Esquinas

  2. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

    Lucia Spicuzza

  3. Cardio-Neuro-Thoracic, Metabol Dept, Pulmonology and Respiratory ICU, Ospedale San Donato, Arezzo, Italy

    Raffaele Scala

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Terán-Tinedo, J., Arróspide, M.C., Lorente, M., Suarez, M., Landete, P. (2023). Response, Complications, Safety, Supervision, and Quality Indicators for NIMV Outside ICU. Risk Factors for Failure. In: Esquinas, A.M., Spicuzza, L., Scala, R. (eds) Noninvasive Ventilation Outside Intensive Care Unit. Noninvasive Ventilation. The Essentials. Springer, Cham. https://doi.org/10.1007/978-3-031-37796-9_8

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  • DOI: https://doi.org/10.1007/978-3-031-37796-9_8

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