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Translational Aspects in Living Mammalian Organisms

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Surgical Research in Implant Dentistry

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Abstract

Translational Research is considered a priority for the National Institutes of Health (NIH) and refers to the “bench-to-bedside” taking advantage of knowledge from basic sciences to produce new products, drugs, devices, and treatment possibilities for patients. The use of the preclinical “in vivo” model in scientific research remains a vital tool in improving our understanding of how biological systems work both in health and disease, and in the development of new medicines, treatments, and technologies. Underpinning this research is a strong commitment to maintaining a rigorous regulatory system that ensures that animal research is carried out only where no practicable alternative exists and under controls that keep suffering to a minimum. This is achieved through robustly applying the principles of the 3Rs (replacement, reduction, and refinement) to all research proposals involving the use of animals. In fact, the researcher must establish a series of points (ethics, bone anatomy, type of defect, etc.) before definitively deciding what animal to use as a model in implant dentistry. The main experimental models used in animal research in terms of implant therapy and applied to Translational Research are implant osseointegration process, immediate implant placement, peri-implantitis therapy, and bone regeneration around implants. It is important, however, to keep in mind that the results, as they stand, obtained from an animal trial, although translational, do not allow any direct correlations and conclusions concerning human situations or treatments to be drawn.

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  1. University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain

    J. Blanco-Carrion, A. Liñares & F. Muñoz

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Blanco-Carrion, J., Liñares, A., Muñoz, F. (2023). Translational Aspects in Living Mammalian Organisms. In: Dard, M.M. (eds) Surgical Research in Implant Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-031-37234-6_8

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